Search results for " nucleus"
showing 10 items of 1270 documents
Radio observations of active galactic nuclei with mm-VLBI
2017
Over the past few decades, our knowledge of jets produced by active galactic nuclei (AGN) has greatly progressed thanks to the development of very-long-baseline interferometry (VLBI). Nevertheless, the crucial mechanisms involved in the formation of the plasma flow, as well as those driving its exceptional radiative output up to TeV energies, remain to be clarified. Most likely, these physical processes take place at short separations from the supermassive black hole, on scales which are inaccessible to VLBI observations at centimeter wavelengths. Due to their high synchrotron opacity, the dense and highly magnetized regions in the vicinity of the central engine can only be penetrated when …
Numerical simulations of dynamics and emission from relativistic astrophysical jets
2013
Broadband emission from relativistic outflows (jets) of active galactic nuclei (AGN) and gamma-ray bursts (GRBs) contains valuable information about the nature of the jet itself, and about the central engine which launches it. Using special relativistic hydrodynamics and magnetohydronamics simulations we study the dynamics of the jet and its interaction with the surrounding medium. The observational signature of the simulated jets is computed using a radiative transfer code developed specifically for the purpose of computing multi-wavelength, time-dependent, non-thermal emission from astrophysical plasmas. We present results of a series of long-term projects devoted to understanding the dyn…
Computational general relativistic force-free electrodynamics
2020
General relativistic force-free electrodynamics is one possible plasma-limit employed to analyze energetic outflows in which strong magnetic fields are dominant over all inertial phenomena. The amazing images of black hole shadows from the galactic center and the M87 galaxy provide a first direct glimpse into the physics of accretion flows in the most extreme environments of the universe. The efficient extraction of energy in the form of collimated outflows or jets from a rotating BH is directly linked to the topology of the surrounding magnetic field. We aim at providing a tool to numerically model the dynamics of such fields in magnetospheres around compact objects, such as black holes an…
Neutron skins of atomic nuclei: per aspera ad astra
2019
The complex nature of the nuclear forces generates a broad range and diversity of observational phenomena. Heavy nuclei, though orders of magnitude less massive than neutron stars, are governed by the same underlying physics, which is enshrined in the nuclear equation of state. Heavy nuclei are expected to develop a neutron-rich skin where many neutrons collect near the surface. Such a skin thickness is strongly sensitive to the poorly-known density dependence of the symmetry energy near saturation density. An accurate and model-independent determination of the neutron-skin thickness of heavy nuclei would provide a significant first constraint on the density dependence of the nuclear symmet…
LOFAR measures the hotspot advance speed of the high-redshift blazar S5 0836+710
2019
Our goal is to study the termination of an AGN jet in the young universe and to deduce physical parameters of the jet and the intergalactic medium. We use LOFAR to image the long-wavelength radio emission of the high-redshift blazar S5 0836+710 on arcsecond scales between 120 MHz and 160 MHz. The LOFAR image shows a compact unresolved core and a resolved emission region about 1.5 arcsec to the southwest of the radio core. This structure is in general agreement with previous higher-frequency radio observations with MERLIN and the VLA. The southern component shows a moderately steep spectrum with a spectral index of about $\gtrsim -1$ while the spectral index of the core is flat to slightly i…
Heavy quarkonium: progress, puzzles, and opportunities
2011
A golden age for heavy quarkonium physics dawned a decade ago, initiated by the confluence of exciting advances in quantum chromodynamics (QCD) and an explosion of related experimental activity. The early years of this period were chronicled in the Quarkonium Working Group (QWG) CERN Yellow Report (YR) in 2004, which presented a comprehensive review of the status of the field at that time and provided specific recommendations for further progress. However, the broad spectrum of subsequent breakthroughs, surprises, and continuing puzzles could only be partially anticipated. Since the release of the YR, the BESII program concluded only to give birth to BESIII; the $B$-factories and CLEO-c flo…
Forward dijets in proton-nucleus collisions at next-to-leading order: the real corrections
2021
Using the CGC effective theory together with the hybrid factorisation, we study forward dijet production in proton-nucleus collisions beyond leading order. In this paper, we compute the "real" next-to-leading order (NLO) corrections, i.e. the radiative corrections associated with a three-parton final state, out of which only two are being measured. To that aim, we start by revisiting our previous results for the three-parton cross-section presented in our previous paper. After some reshuffling of terms, we deduce new expressions for these results, which not only look considerably simpler, but are also physically more transparent. We also correct several errors in this process. The real NLO …
Effects of caspase inhibitors (z-VAD-fmk, z-VDVAD-fmk) on Nile Red fluorescence pattern in 7-ketocholesterol-treated cells: Investigation by flow cyt…
2007
Background: The 7-ketocholesterol (7KC)-induced cell death has some characteristics of apoptosis and is associated with polar lipid accumulation. So, we investigated the effects of the broad-spectrum caspase inhibitor z-VAD-fmk and of the caspase-2 inhibitor z-VDVAD-fmk on lipid profile evaluated by staining with Nile Red (NR). Methods: The 7KC-treated human monocytic U937 cells were cultured in the absence or in the presence of the caspase inhibitors z-VAD-fmk or z-VDVAD-fmk. When staining with NR is performed, neutral and polar lipids have yellow and orange/red emission, respectively, and fluorescence was then analyzed by flow cytometry (FCM) and by confocal laser scanning microscopy (CLS…
STN area detection using K-NN classifiers for MER recordings in Parkinson patients during neurostimulator implant surgery
2016
Deep Brain Stimulation (DBS) applies electric pulses into the subthalamic nucleus (STN) improving tremor and other symptoms associated to Parkinson's disease. Accurate STN detection for proper location and implant of the stimulating electrodes is a complex task and surgeons are not always certain about final location. Signals from the STN acquired during DBS surgery are obtained with microelectrodes, having specific characteristics differing from other brain areas. Using supervised learning, a trained model based on previous microelectrode recordings (MER) can be obtained, being able to successfully classify the STN area for new MER signals. The K Nearest Neighbours (K-NN) algorithm has bee…
Zfp819, a novel KRAB-zinc finger protein, interacts with KAP1 and functions in genomic integrity maintenance of mouse embryonic stem cells
2013
AbstractPluripotency is maintained by both known and unknown transcriptional regulatory networks. In the present study, we have identified Zfp819, a KRAB-zinc finger protein, as a novel pluripotency-related factor and characterized its role in pluripotent stem cells. We show that Zfp819 is expressed highly in various types of pluripotent stem cells but not in their differentiated counterparts. We identified the presence of non-canonical nuclear localization signals in particular zinc finger motifs and identified them as responsible for the nuclear localization of Zfp819. Analysis of the Zfp819 promoter region revealed the presence of a transcriptionally active chromatin signature. Moreover,…