Search results for " obesity"

Hyperinsulinaemia and reninaldosterone system in morbid obesity.

1999

A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol

2011

Recent genome-wide association (GWA) studies described 95 loci controlling serum lipid levels. These common variants explain ∼25% of the heritability of the phenotypes. To date, no unbiased screen for gene–environment interactions for circulating lipids has been reported. We screened for variants that modify the relationship between known epidemiological risk factors and circulating lipid levels in a meta-analysis of genome-wide association (GWA) data from 18 population-based cohorts with European ancestry (maximum N = 32,225). We collected 8 further cohorts (N = 17,102) for replication, and rs6448771 on 4p15 demonstrated genome-wide significant interaction with waist-to-hip-ratio (WHR) on …

OR-039 Normal-weight obesity and physical fitness in Chinese university students: an overlooked association

2018

Objective The primary aim of this study was to examine the associations of normal weight obesity with physical fitness in Chinese university students. As a secondary aim, we assessed whether possible differences in physical fitness between students classified as NWO and normal weight non-obese (NWNO) were mediated by skeletal muscles mass.
 Methods A total of 383 students (205 males and 178 females, aged 18–24 years) from two universities volunteered to participate in this study. Body height and weight were measured by standard procedures and body composition was assessed by a bio-impedance device (InBody 720). NWO was defined by a BMI of 18.5 - 23.9 kg/m2 and a body fat percentage of …

Impact of obstructive sleep apnea on metabolic dysfunction in severe obesity.

2011

Obstructive Sleep Apnoea (OSA) seems to worsen metabolism. This effect has not evaluated in morbid obesity (MO). We hypothesized that the metabolic profile is more impaired in MO patients with OSA than in those without and investigated whether any specific metabolic dysfunction is related to OSA in MO. A prospective multi-centre cross-sectional study was conducted in consecutive subjects before bariatric surgery. OSA was defined as apnoea-hypopnoea index (AHI)≥15 by overnight polysomnography (PSG). Anthropometrical, blood pressure (BP) and fasting blood measurements were obtained the morning after. Metabolic Syndrome (MetS) was defined according to NCEP ATPIII modified criteria. 159 patient…

The importance of extranodal extension in metastatic head and neck squamous cell carcinoma, in the light of the new AJCC cancer staging system

2017

Metabolic disorders across hepatocellular carcinoma in Italy

2018

Background: Metabolic disorders are well-known risk factors for HCC. Conversely, their impact on the natural history of HCC is not established. This study aimed at evaluating the impact of metabolic disorders on clinical features, treatment and survival of HCC patients regardless of its aetiology. Methods: We analysed the ITA.LI.CA database regarding 839 HCC patients prospectively collected. The following metabolic features were analysed: BMI, diabetes, arterial hypertension, hypercholesterolaemia and hypertriglyceridaemia. According to these features, patients were divided into 3 groups: 0-1, 2 and 3-5 metabolic features. Results: As compared with patients with 0-1 metabolic features, pati…

Influence of cachexia and sarcopenia on survival in pancreatic ductal adenocarcinoma: a systematic review.

2014

Abstract Background/objectives Cachexia affects ∼80% of pancreatic cancer patients. An international consensus defines cachexia as an ongoing loss of skeletal muscle mass (sarcopenia) with or without loss of fat, which impairs body functioning and cannot be reversed by conventional nutritional measures. Weight loss percentage and elevated inflammation markers have been employed to define this condition earlier. This review aimed to assess the prevalence and consequences of cachexia and sarcopenia on survival in patients with pancreatic ductal adenocarcinoma. Methods The systematic review was performed by searching the articles with preset terms published in PubMed and Cochrane Database unti…

Genetic Variability in Selected ZnT8 SNPs in the Opolskie Voivodeship (Poland) - Relationship with Type 2 Diabetes and its Complications and Accompan…

2023

Introduction: Type-2 Diabetes Mellitus (DM2) is of multigeneous origin, and its course may be modified by autoimmune mechanisms. It can be assumed that the clinically different course of diabetes depends, among others, on the genetically determined efficiency of the mechanisms of zinc homeostasis maintenance. The study of the relationship of mutations in the gene encoding ZnT8 with the tendency to the occurrence of diabetes and its course may result in new therapeutic possibilities in the future. It is also interesting because in leukocytes only ZnT8 shows significant individual variability in expression under physiological and pathological conditions, which indicates its genetic determinan…

Indicaxanthin from Opuntia ficus-indica Fruit Ameliorates Glucose Dysmetabolism and Counteracts Insulin Resistance in High-Fat-Diet-Fed Mice

2021

Obesity-related dysmetabolic conditions are amongst the most common causes of death globally. Indicaxanthin, a bioavailable betalain pigment from Opuntia ficus-indica fruit, has been demonstrated to modulate redox-dependent signalling pathways, exerting significant anti-oxidative and anti-inflammatory effects in vitro and in vivo. In light of the strict interconnections between inflammation, oxidative stress and insulin resistance (IR), a nutritionally relevant dose of indicaxanthin has been evaluated in a high-fat diet (HFD) model of obesity-related IR. To this end, biochemical and histological analysis, oxidative stress and inflammation evaluations in liver and adipose tissue were carried…

Exercise and Healthy Eating Intentions and Behaviors among Normal Weight and Overweight/Obese Adults

2016

Strong evidence suggests that exercise and eating behaviours are strongly linked. Theory of Planned Behaviour is a theoretical framework that has been successfully used to explain and predict both behaviours. The aim of the present study is to explore the constructs of Theory of Planned Behavior (TPB) that better predicts exercise and healthy eating: a) intentions and b) selfreported behaviors among normal weight and overweight/obese adults. Participants were 361 adults in Greece (women: N = 152). According to their BMI scores, they have been grouped into normal weight and overweight/obese. Data were collected with an online questionnaire assessing variables of the theory of planned behavio…