Search results for " observation."

showing 10 items of 434 documents

Decline in Coccolithophore Diversity and Impact on Coccolith Morphogenesis Along a Natural CO2 Gradient

2014

A natural pH gradient caused by marine CO2 seeps off Vulcano Island (Italy) was used to assess the effects of ocean acidification on coccolithophores, which are abundant planktonic unicellular calcifiers. Such seeps are used as natural laboratories to study the effects of ocean acidification on marine ecosystems, since they cause long-term changes in seawater carbonate chemistry and pH, exposing the organisms to elevated CO2 concentrations and therefore mimicking future scenarios. Previous work at CO2 seeps has focused exclusively on benthic organisms. Here we show progressive depletion of 27 coccolithophore species, in terms of cell concentrations and diversity, along a calcite saturation …

Ocean Acidification International Coordination Centre (OA-ICC)TemperateSalinityCommunity composition and diversityinorganicAlkalinityCoccospheres malformedMediterranean Sea Acidification in a Changing Climate MedSeATemperature waterCarbon inorganic dissolvedCalculated using seacarb after Nisumaa et al 2010Aragonite saturation stateAlkalinity totaltotalCO2 ventpHPelagosTemperaturedissolvedCarbonate ionPartial pressure of carbon dioxide (water) at sea surface temperature (wet air)Earth System ResearchmalformedField observationPotentiometric titrationCalcite saturation stateCoccospheresPotentiometricwaterGrowth MorphologyMediterranean Sea Acidification in a Changing Climate (MedSeA)Ocean Acidification International Coordination Centre OA ICCMediterranean SeaBicarbonate ionCalculated using seacarb after Nisumaa et al. (2010)Calculated using CO2SYSfungiCarbonate system computation flagCoccospheres corrodedFugacity of carbon dioxide (water) at sea surface temperature (wet air)CarbonBiomass/Abundance/Elemental compositionPartial pressure of carbon dioxide water at sea surface temperature wet airSample IDCarbon dioxidecorrodedEntire communityGrowth/MorphologyPhytoplanktonFugacity of carbon dioxide water at sea surface temperature wet airBiomass Abundance Elemental compositionCoast and continental shelfNumber of species
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Shallow water marine sediment bacterial community shifts along a natural CO2 gradient in the Mediterranean Sea Off vulcano, Italy

2014

The effects of increasing atmospheric CO(2) on ocean ecosystems are a major environmental concern, as rapid shoaling of the carbonate saturation horizon is exposing vast areas of marine sediments to corrosive waters worldwide. Natural CO(2) gradients off Vulcano, Italy, have revealed profound ecosystem changes along rocky shore habitats as carbonate saturation levels decrease, but no investigations have yet been made of the sedimentary habitat. Here, we sampled the upper 2 cm of volcanic sand in three zones, ambient (median pCO(2) 419 µatm, minimum Omega (arag) 3.77), moderately CO(2)-enriched (median pCO(2) 592 µatm, minimum Omega (arag) 2.96), and highly CO(2)-enriched (median pCO(2) 1611…

Ocean Acidification International Coordination Centre (OA-ICC)TemperateSalinityPotentiometric titrationCalcite saturation stateCommunity composition and diversityPotentiometricinorganicwaterAlkalinitySiteFigureBenthosTemperature waterCarbon inorganic dissolvedAbundanceCalculated using seacarb after Nisumaa et al 2010Ocean Acidification International Coordination Centre OA ICCMediterranean SeaBicarbonate ionAragonite saturation stateSoft-bottom communityAlkalinity totalLONGITUDEtotalCalculated using seacarb after Nisumaa et al. (2010)CO2 ventSpeciesShannon Diversity IndexpHCalculated using CO2SYSTemperatureCarbonate system computation flagdissolvedFugacity of carbon dioxide (water) at sea surface temperature (wet air)Carbonate ionCarbonPartial pressure of carbon dioxide (water) at sea surface temperature (wet air)Partial pressure of carbon dioxide water at sea surface temperature wet airCarbon dioxideSoft bottom communityEntire communityEarth System ResearchLATITUDEFugacity of carbon dioxide water at sea surface temperature wet airGroupCoast and continental shelfField observationClass
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Cultural institutions as agents of urban and community regeneration in the (post-)pandemic city. The case of the «Laboratorio Zen Insieme» in Palermo

2022

Although all cities in the world have been affected by the COVID-19 pandemic, its impacts on the territories, yet to be understood, are unevenly distributed, revealing extremely varied imbalances depending on the places. However, it is clear that the virus and its variants have aggravated pre-existing socio-spatial inequalities, creating new ones and bringing attention back to those implications between space, planning, public health and citizenship that are at the origins of contemporary urbanism. In a reference framework in which the crisis is globalized but unequal and in the absence of a welfare system capable of responding to the urgencies of the most marginalized social contexts and g…

Olsen 2018Settore ICAR/21 - UrbanisticaSettore M-GGR/01 - GeografiaSacco and Blessi 2009). In the current (post-) pandemic context and through the lens of a southern European perspective the purpose of this article is to critically reflect about the role of culture as possible vehicle of urban and community regeneration. In particular we will focus on the activities of the no profit organization «Laboratorio Zen Insieme» in ZEN2 one of the last large popular and peripheral neighborhoods built in Palermo at the end of 80s in order to explore and understand how cultural practices work as agent of urban and social transformation capable of addressing emerging issues especially in the pandemic scenario we are experiencing. Thecasestudy has been conducted through analysis of documents participative observations (Honer and Hitzler 2015) and qualitative in-depth interviews with key actors involved in the conception organization and management of the activities carried out by Laboratorio Zen Insieme with representatives of local institutions and non-formal conversations with participants of the workshops heldin the neighborhood. The experience we narrate finds that cultural practices have re-conceptualized their design and functions as strategies of urban and community regeneration and at the same time have contributed to answer to emergent issues in developing proximity and local based strategies facing up to problems inherent civil rights educationalpoverty socio-spatial justice and have changed the image and identity of urban places they inhabit.In this sense the research provides a framework for development of strategies and legitimization for cultural practices and a point of discussionabouttheirrolein urban development.Although all cities in the world have been affected by the COVID-19 pandemic its impacts on the territories yet to be understood are unevenly distributed revealing extremely varied imbalances depending on the places. However it is clear that the virus and its variants have aggravated pre-existing socio-spatial inequalities creating new ones and bringing attention back to those implications between space planning public health and citizenship that are at the origins of contemporary urbanism. In a reference framework in which the crisis is globalized but unequal and in the absence of a welfare system capable of responding to the urgencies of the most marginalized social contexts and groups a response to the new social and individual needs has been offered by cultural institutions that play a role of territorial agency often independently or in the absence of political institutions. Far from the idea of entertainment and divertissement it is in fact increasingly clear how the practices of cultural innovation experimenting with various forms of action and participation can in some cases play a fundamental role in the processes of social cohesion and community building representing an antidote to the worsening of the phenomena of marginalization and socio-spatial inequalities within cities and territories (Colantonio and Dixon 2011
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Deep MRD profiling defines outcome and unveils different modes of treatment resistance in standard- and high-risk myeloma

2021

PETHEMA/GEM Cooperative Group.

OncologyAdultBoron CompoundsMalemedicine.medical_specialtyNeoplasm ResidualPhysics::Instrumentation and DetectorsClinical Trials and ObservationsImmunologyPatient subgroupsGlycineDrug resistanceBiochemistryDexamethasoneBortezomibhemic and lymphatic diseasesInternal medicineAntineoplastic Combined Chemotherapy ProtocolsmedicineNeoplasmHumansProgression-free survivalTreatment resistanceLenalidomideComplete responseMultiple myelomaAgedChromosome AberrationsLymphoid Neoplasiabusiness.industryCell BiologyHematologyMiddle Agedmedicine.diseaseFlow CytometryProgression-Free Survivalbody regionsClinical trialTreatment OutcomeDrug Resistance NeoplasmFemalebusinessMultiple Myeloma
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Sorafenib: from literature to clinical practice

2013

Sorafenib is considered the standard systemic therapy for hepatocellular carcinoma (HCC), in patients with well-preserved liver function (Child-Pugh A class) and advanced-stage HCC (BCLC-C) or in patients with HCC progressing after locoregional therapies, with a high grade of recommendation. The approval of sorafenib for this indication was grounded on the efficacy and the safety results reported by two international randomized, controlled trials, the SHARP and the Asia-Pacific studies. In addition, the efficacy and the safety of sorafenib in clinical practice are addressed by several field-practice experiences, including the multinational GIDEON study and the SOFIA study. Finally, further …

OncologyTime Factorsadverse eventPharmacologySystemic therapylaw.inventionTranslational Research Biomedicalobservational studieAntineoplastic AgentRandomized controlled trialRisk FactorslawMolecular Targeted TherapyHCCTranslational Medical Researchadverse events; clinical practice; observational studies; randomized clinical trials; sorafenib; Animals; Antineoplastic Agents; Carcinoma Hepatocellular; Evidence-Based Medicine; Humans; Liver Neoplasms; Neoplasm Staging; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Randomized Controlled Trials as Topic; Risk Factors; Time Factors; Treatment Outcome; Molecular Targeted Therapy; Translational Medical ResearchRandomized Controlled Trials as TopicEvidence-Based MedicineLiver NeoplasmsHematologyclinical practiceTreatment OutcomeOncologyLiver NeoplasmHepatocellular carcinomaHumanmedicine.drugNiacinamidePhenylurea CompoundSorafenibmedicine.medical_specialtyCarcinoma HepatocellularTime FactorProtein Kinase InhibitorAntineoplastic AgentsInternal medicinemedicineAnimalsHumansAdverse effectProtein Kinase InhibitorsneoplasmsNeoplasm StagingAnimalbusiness.industryPhenylurea CompoundsRisk FactorEvidence-based medicinerandomized clinical trialmedicine.diseasedigestive system diseasessorafenibObservational studyLiver functionbusiness
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Tea Consumption and Risk of Cancer

2020

Tea is one of the most widely consumed beverages, but its association with cancer risk remains controversial and unclear. We performed an umbrella review to clarify and determine the associations between tea consumption and various types of cancer by summarizing and recalculating the existing meta-analyses. Meta-analyses of observational studies reporting associations between tea consumption and cancer risk were searched on PubMed and Embase. Associations found to be statistically significant were further classified into levels of evidence (convincing, suggestive, or weak), based on P value, between-study heterogeneity, prediction intervals, and small study effects. Sixty-four observational…

Oncologymedicine.medical_specialtyteaMedicine (miscellaneous)Review03 medical and health sciences0302 clinical medicineBreast cancerInternal medicinemedicinecancer030212 general & internal medicineLung cancerProspective cohort studyThyroid cancercancer meta-analysis oral cancer tea umbrella reviewNutrition and Dieteticsumbrella reviewbusiness.industrymeta-analysis oral cancer umbrella review Feeding Behavior Humans Incidence Observational Studies as Topic Prospective Studies Risk Factors Neoplasms TeaCanceroral cancermedicine.diseasemeta-analysis030220 oncology & carcinogenesisMeta-analysisOvarian cancerLiver cancerbusinessFood ScienceAdvances in Nutrition
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Acoustic and optical variations during rapid downward motion episodes in the deep north-western Mediterranean Sea

2011

An Acoustic Doppler Current Profiler (ADCP) was moored at the deep-sea site of the ANTARES neutrino telescope near Toulon, France, thus providing a unique opportunity to compare high-resolution acoustic and optical observations between 70 and 170 m above the sea bed at 2475 m. The ADCP measured downward vertical currents of magnitudes up to 0.03 m s-1 in late winter and early spring 2006. In the same period, observations were made of enhanced levels of acoustic reflection, interpreted as suspended particles including zooplankton, by a factor of about 10 and of horizontal currents reaching 0.35 m s-1. These observations coincided with high light levels detected by the telescope, interpreted …

Optical telescopesDense water formation010504 meteorology & atmospheric sciencesDense watersBoundary currentWave reflectionOptical photo-multiplier observationsSuspended loadWATER FORMATIONOceanography01 natural scienceslaw.inventionPhysics - GeophysicsObservational methodMediterranean sea86-02lawDeep MediteraneanSeabedPhosphorescenceDeep seaCurrent (stream)VARIABILITYOptical methodOceanographyAcoustic variables measurementNorthern boundary currentantares neutrino telescope; deep mediteranean; northern boundary current; acoustic adcp observations; episodic downward current; dense water formation; bioluminescence; optical photo-multiplier observationsFísica nuclearAcoustic Doppler Current ProfilerBioluminescenceAstrophysics - Instrumentation and Methods for AstrophysicsANTARES neutrino telescopeGeology[PHYS.ASTR.IM]Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM]Acoustic ADCP observationsCIRCULATIONFOS: Physical sciencesAquatic ScienceLIGURIAN SEAZooplanktonZooplanktonTelescopeAcoustic Doppler current profilerOCEANOPTICAL PHOTO-MULTIPLIERMediterranean Sea14. Life underwaterInstrumentation and Methods for Astrophysics (astro-ph.IM)0105 earth and related environmental sciencesLight reflectionANTARESAcoustic wave010505 oceanographyAdvectionDense waterElementary particlesZOOPLANKTON BIOMASSDoppler effectMARINE RESEARCHESGeophysics (physics.geo-ph)Boundary current[SDU.ASTR.IM]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM]Boundary currentsCONVECTION13. Climate actionFISICA APLICADAAdvectionEpisodic downward currentMediterranean Sea (Northwest)SYSTEMTelescopes
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The ANTARES telescope neutrino alert system

2012

The ANTARES telescope has the capability to detect neutrinos produced in astrophysical transient sources. Potential sources include gamma-ray bursts, core collapse supernovae, and flaring active galactic nuclei. To enhance the sensitivity of ANTARES to such sources, a new detection method based on coincident observations of neutrinos and optical signals has been developed. A fast online muon track reconstruction is used to trigger a network of small automatic optical telescopes. Such alerts are generated for special events, such as two or more neutrinos, coincident in time and direction, or single neutrinos of very high energy.

Optical telescopesPhysics::Instrumentation and DetectorsAstrophysics7. Clean energy01 natural sciencesGamma ray burstsFOLLOW-UP OBSERVATIONSlaw.inventionlawFlaring activeVery high energiesHigh Energy Astrophysical Phenomena (astro-ph.HE)PhysicsGAMMA-RAY BURSTS[SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph][SDU.ASTR.HE]Sciences of the Universe [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE]Astrophysics::Instrumentation and Methods for AstrophysicsSupernovaNeutrino detectorNeutrino astronomyFísica nuclearNeutrinoAstrophysics - Instrumentation and Methods for AstrophysicsAstrophysics - High Energy Astrophysical PhenomenaFLUX[PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE][PHYS.ASTR.IM]Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM]Astrophysics::High Energy Astrophysical PhenomenaFOS: Physical sciencesOptical telescopeTelescopeMuon tracksCoincidentSEARCHDetection methods0103 physical sciencesCore collapse supernovae010306 general physicsOptical follow-upInstrumentation and Methods for Astrophysics (astro-ph.IM)Neutronsantares; neutrino astronomy; optical follow-up; transient sourcesANTARES010308 nuclear & particles physicsGamma raysAstronomyAstronomy and AstrophysicsAlert systemsStarsTransient sources[SDU.ASTR.IM]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM]Optical signalsPotential sources13. Climate actionFISICA APLICADAHigh Energy Physics::ExperimentNeutrino astronomyGamma-ray burst
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Fluorescence explorer (FLEX): An optimised payload to map vegetation photosynthesis from space

2006

The FLuorescence EXplorer (FLEX) mission proposes to launch a satellite for the global monitoring of steady-state chlorophyll fluorescence in terrestrial vegetation. Fluorescence is a sensitive probe of photosynthetic function in both healthy and physiologically perturbed vegetation, and a powerful non-invasive tool to track the status, resilience, and recovery of photochemical processes and moreover provides important information on overall photosynthetic performance with implications for related carbon sequestration. The early responsiveness of fluorescence to atmospheric, soil and plant water balance, as well as to atmospheric chemistry and human intervention in land usage makes it an ob…

OptimizationEarth observationAtmospheric chemistryAlterra - Centrum Geo-informatieFluorescenceremote sensingLaboratory of Geo-information Science and Remote SensingThree-instrument arrayFLEXLife ScienceLaboratorium voor Geo-informatiekunde en Remote SensingWageningen Environmental ResearchPhotosynthesisSpace researchWater balanceChlorophyll fluorescenceRemote sensingVegetationResiliencePayloadChemistryVegetationCentre Geo-informationPE&RCEarth system scienceFLuorescence EXplorer (FLEX)Space research[SDE]Environmental SciencesEarth (planet)SoilsTerrestrial vegetationSatellite
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Como gerentes de nível médio contribuem para o processo de formação de estratégia: conexão entre processos estratégicos e práticas estratégicas

2010

The role of middle management is essential when managing integrative and emergent strategy formation processes. We stand out the importance of its role connecting micro and macro organizational level offering a very important contribution when examining the strategy-as-practice perspective and integrative strategy formation process. The main goal of this research is to analyse the relationship between the integrative strategy formation process and the roles of middle management under the strategy-as-practice perspective. To check it out we adopted a qualitative methodology droving a case analysis in a Spanish University. Data was collected by means of personal interviews with members of dif…

Organizational Behavior and Human Resource ManagementInformation Systems and Managementprocesso-integrador-de-formação-da-estratégiaStrategy and ManagementManagement Science and Operations Researchstrategy formation processstrategizingcase studyestrategia como prácticaManagement of Technology and Innovationestudio de casoSociologyBusiness and International ManagementMarketingMiddle managerWelfare economicsDirect observationMiddle managementstrategy-as-practiceestratégia-como-práticaManagementproceso integrador de formación de la estrategiaestudo de casoIndustrial relationsMiddle managementBusiness Management and Accounting (miscellaneous)Case analysisOrganizational levelQualitative research
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