Search results for " observations"
showing 10 items of 100 documents
Modeling Atmospheric Turbulence via Rapid Distortion Theory: Spectral Tensor of Velocity and Buoyancy
2017
Abstract A spectral tensor model is presented for turbulent fluctuations of wind velocity components and temperature, assuming uniform vertical gradients in mean temperature and mean wind speed. The model is built upon rapid distortion theory (RDT) following studies by Mann and by Hanazaki and Hunt, using the eddy lifetime parameterization of Mann to make the model stationary. The buoyant spectral tensor model is driven via five parameters: the viscous dissipation rate ε, length scale of energy-containing eddies L, a turbulence anisotropy parameter , gradient Richardson number (Ri) representing the local atmospheric stability, and the rate of destruction of temperature variance . Model outp…
Multimessenger search for sources of gravitational waves and high-energy neutrinos: Initial results for LIGO-Virgo and IceCube
2014
Made available in DSpace on 2022-04-29T07:21:49Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-11-17 We report the results of a multimessenger search for coincident signals from the LIGO and Virgo gravitational-wave observatories and the partially completed IceCube high-energy neutrino detector, including periods of joint operation between 2007-2010. These include parts of the 2005-2007 run and the 2009-2010 run for LIGO-Virgo, and IceCube's observation periods with 22, 59 and 79 strings. We find no significant coincident events, and use the search results to derive upper limits on the rate of joint sources for a range of source emission parameters. For the optimistic assumption of …
Real‐world evidence of tisagenlecleucel for the treatment of relapsed or refractory large B‐cell lymphoma
2021
Abstract Tisagenlecleucel (tisa‐cel) is a second‐generation autologous CD19‐targeted chimeric antigen receptor (CAR) T‐cell therapy approved for relapsed/refractory (R/R) large B‐cell lymphoma (LBCL). The approval was based on the results of phase II JULIET trial, with a best overall response rate (ORR) and complete response (CR) rate in infused patients of 52% and 40%, respectively. We report outcomes with tisa‐cel in the standard‐of‐care (SOC) setting for R/R LBCL. Data from all patients with R/R LBCL who underwent leukapheresis from December 2018 until June 2020 with the intent to receive SOC tisa‐cel were retrospectively collected at 10 Spanish institutions. Toxicities were graded accor…
Dynamics of complement activation in aHUS and how to monitor eculizumab therapy.
2014
Atypical hemolytic-uremic syndrome (aHUS) is associated with genetic complement abnormalities/anti–complement factor H antibodies, which paved the way to treatment with eculizumab. We studied 44 aHUS patients and their relatives to (1) test new assays of complement activation, (2) verify whether such abnormality occurs also in unaffected mutation carriers, and (3) search for a tool for eculizumab titration. An abnormal circulating complement profile (low C3, high C5a, or SC5b-9) was found in 47% to 64% of patients, irrespective of disease phase. Acute aHUS serum, but not serum from remission, caused wider C3 and C5b-9 deposits than control serum on unstimulated human microvascular endotheli…
Chemoimmunotherapy with O-FC in previously untreated patients with chronic lymphocytic leukemia
2011
We conducted an international phase 2 trial to evaluate 2 dose levels of ofatumumab, a human CD20 mAb, combined with fludarabine and cyclophosphamide (O-FC) as frontline therapy for chronic lymphocytic leukemia (CLL). Patients with active CLL were randomized to ofatumumab 500 mg (n = 31) or 1000 mg (n = 30) day 1, with fludarabine 25 mg/m2 and cyclophosphamide 250 mg/m2 days 2-4, course 1; days 1-3, courses 2-6; every 4 weeks for 6 courses. The first ofatumumab dose was 300 mg for both cohorts. The median age was 56 years; 13% of patients had a 17p deletion; 64% had β2-microglobulin > 3.5 mg/L. Based on the 1996 National Cancer Institute Working Group (NCI-WG) guidelines, the complete respo…
The Mutational Landscape of Acute Myeloid Leukaemia Predicts Responses and Outcomes in Elderly Patients from the PETHEMA-FLUGAZA Phase 3 Clinical Tri…
2021
This article belongs to the Collection The Biomarkers for the Diagnosis and Prognosis in Cancer.
The Flipped Classroom: a Way to Decrease Boredom and Encourage Student Motivation. La classe capovolta: un modo per diminuire la noia ed incoraggiare…
2016
Recenti studi hanno mostrato l'effetto della noia sul successo. L'esperienza della noia vissuta da molti studenti, insieme con i suoi effetti deleteri, implica chiaramente che educatori ed insegnanti, in quanto responsabili della progettazione di ambienti di apprendimento, prestino maggiore attenzione a questa emozione. Questo contributo intende esaminare l'impatto del modello di insegnamento capovolto sul processo di apprendimento dello studente. Nella ricerca sono state utilizzate differenti metodologie, tra cui un inventario sulla percezione degli studenti e l'osservazione delle pratiche di insegnamento, per indagare se ed in che modo gli insegnanti riescono a gestire la noia in modo div…
Search for gamma ray bursts with the ARGO-YBJ detector in scaler mode
2009
We report on the search for Gamma Ray Bursts (GRBs) in the energy range 1-100 GeV in coincidence with the prompt emission detected by satellites using the Astrophysical Radiation with Ground-based Observatory at YangBaJing (ARGO-YBJ) air shower detector. Thanks to its mountain location (Yangbajing, Tibet, P.R. China, 4300 m a.s.l.), active surface (about 6700 m**2 of Resistive Plate Chambers), and large field of view (about 2 sr, limited only by the atmospheric absorption), the ARGO-YBJ air shower detector is particularly suitable for the detection of unpredictable and short duration events such as GRBs. The search is carried out using the "single particle technique", i.e. counting all the …
SUSY-GUTs, SUSY-Seesaw and the Neutralino Dark Matter
2007
19 pages, 7 figures.-- ISI Article Identifier: 000249788800048.-- ArXiv pre-print available at: http://arxiv.org/abs/0704.3518
Updated CMB and x- and gamma-ray constraints on Majoron dark matter
2013
The Majoron provides an attractive dark matter candidate, directly associated with the mechanism responsible for spontaneous neutrino mass generation within the standard model SU(3)(c) circle times SU(2)(L) circle times U(1)(Y) framework. Here we update the cosmological and astrophysical constraints on Majoron dark matter coming from the cosmic microwave background and a variety of x- and gamma-ray observations.