Search results for " oligomers"
showing 9 items of 19 documents
Oligomerization of Concanavalin A in live cells detected by fluctuation analysis.
2009
Small Molecules Targeting and Modulating Toxic Tau Oligomeric Strains
Alzheimer’s disease (AD) is one of over 18 different disorders known as tauopathies, characterized by the pathological aggregation and accumulation of tau, a microtubule-associated protein. Tau aggregates are heterogeneous and can be divided into two major groups: large metastable neurofibrillary tangles (NFTs) and oligomers. Recently, it has been shown that tau oligomers are highly toxic in vitro and efficient seeds for the propagation of pathology as compared to NFTs. While the toxicity of recombinant tau oligomers has been studied extensively, within the same aggregation state, tau exhibits conformational differences, termed tau oligomeric strains. Due to the dynamic nature of these stra…
Fibrillogenesis of hen egg-white lysozyme at acidic pH
2009
Role of electrostatic interactions in the fibrillogenesis of lysozyme
2011
(E)-2-cyano-3-(5'-piperidin-1-yl-2,2'-bithien-5-yl)acrylic acid: a new fluorescent probe for detecting prefibrillar oligomers
2013
Efficient stabilisation of a dihydrogenphosphate tetramer and a dihydrogenpyrophosphate dimer by a cyclic pseudopeptide containing 1,4-disubstituted …
2017
A cyclic pseudooctapeptide 2 is described containing 1,4-disubstituted 1,2,3-triazole moieties. This compound features eight converging hydrogen bond donors along the ring, namely four amide NH and four triazole CH groups, which enable 2 to engage in interactions with anions. While fully deprotonated sulfate anions exhibit only moderate affinity for 2, protonated anions such as dihydrogenpyrophosphate and dihydrogenphosphate anions are strongly bound. Complexation of the phosphate-derived anions involves sandwiching of a dihydrogenpyrophosphate dimer or a dihydrogenphosphate tetramer between two pseudopeptide rings. X-ray crystallography provided structural information, while 1H NMR spectro…
Spatial localization of hotspots in Fano-resonant plasmonic oligomers for surface-enhanced coherent anti-Stokes Raman scattering
2020
AbstractRealization of Fano resonance in plasmonic oligomers is often exploited to design efficient plasmonic substrates for surface-enhanced coherent anti-Stokes Raman scattering. Disk-type Fano-resonant plasmonic oligomers are widely used to enhance the Raman signal of the probe material. Generally, hot spots are generated in those oligomers at different spatial locations at different wavelengths and only a few spatially overlapping hot spots at multiple wavelengths can be achieved with oblique incidence of excitation light. In this work, we proposed hexagonal gold nanoparticle based Fano-resonant plasmonic oligomers that can yield higher number of spatially overlapped hot spots compared …
Efficient stabilisation of a dihydrogenphosphate tetramer and a dihydrogenpyrophosphate dimer by a cyclic pseudopeptide containing 1,4-disubstituted …
2017
A cyclic pseudooctapeptide 2 is described containing 1,4-disubstituted 1,2,3-triazole moieties. This compound features eight converging hydrogen bond donors along the ring, namely four amide NH and four triazole CH groups, which enable 2 to engage in interactions with anions. While fully deprotonated sulfate anions exhibit only moderate affinity for 2, protonated anions such as dihydrogenpyrophosphate and dihydrogenphosphate anions are strongly bound. Complexation of the phosphate-derived anions involves sandwiching of a dihydrogenpyrophosphate dimer or a dihydrogenphosphate tetramer between two pseudopeptide rings. X-ray crystallography provided structural information, while 1 H NMR spectr…