Search results for " online"
showing 10 items of 210 documents
Absolute and relative quantification of RNA modifications via biosynthetic isotopomers
2014
In the resurging field of RNA modifications, quantification is a bottleneck blocking many exciting avenues. With currently over 150 known nucleoside alterations, detection and quantification methods must encompass multiple modifications for a comprehensive profile. LC-MS/MS approaches offer a perspective for comprehensive parallel quantification of all the various modifications found in total RNA of a given organism. By feeding (13)C-glucose as sole carbon source, we have generated a stable isotope-labeled internal standard (SIL-IS) for bacterial RNA, which facilitates relative comparison of all modifications. While conventional SIL-IS approaches require the chemical synthesis of single mod…
Computational identification of cell-specific variable regions in ChIP-seq data.
2019
ABSTRACT Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is used to identify genome-wide DNA regions bound by proteins. Several sources of variation can affect the reproducibility of a particular ChIP-seq assay, which can lead to a misinterpretation of where the protein under investigation binds to the genome in a particular cell type. Given one ChIP-seq experiment with replicates, binding sites not observed in all the replicates will usually be interpreted as noise and discarded. However, the recent discovery of high-occupancy target (HOT) regions suggests that there are regions where binding of multiple transcription factors can be identified. To investigate these regions,…
The on-line curvilinear component analysis (onCCA) for real-time data reduction
2015
Real time pattern recognition applications often deal with high dimensional data, which require a data reduction step which is only performed offline. However, this loses the possibility of adaption to a changing environment. This is also true for other applications different from pattern recognition, like data visualization for input inspection. Only linear projections, like the principal component analysis, can work in real time by using iterative algorithms while all known nonlinear techniques cannot be implemented in such a way and actually always work on the whole database at each epoch. Among these nonlinear tools, the Curvilinear Component Analysis (CCA), which is a non-convex techni…
Price dispersion, competition, and the role of online travel agents: Evidence from business routes in the Italian airline market
2014
Abstract In this article, using data from the Italian airline market, we study the role of online travel agents (OTAs) in driving price dispersion as compared to the effect of airlines’ websites. Specifically, we investigate how distinctive factors between OTAs and airlines’ direct channels influence price dispersion. We find that after controlling for OTAs’ features related to airline competition, price dispersion should be lower in the OTA channel relative to airlines’ direct channels. On the other hand, we also find that OTAs’ features related to the presence of airline competition play in favor of higher price dispersion in such indirect channel.
Logical Key Hierarchy for Group Management in Distributed Online Social Networks
2016
Distributed Online Social Networks (DOSNs) have recently been proposed to shift the control over user data from a unique entity to the users of the DOSN themselves. In this paper, we focus our attention on the problem of privacy preserving content sharing to a large group of users of the DOSNs. Several solutions, based on cryptographic techniques, have been recently proposed. The main challenge here is the definition of a scalable and decentralized approach that: i) minimizes the re-encryption of the contents published in a group when the composition of the group changes and ii) enables a fast distribution of the cryptographic keys to all the members (n) of a group, each time a new user is …
Relation between adaptive learning actions and profiles of MOOCs users
2016
The overcrowding and the heterogeneity of participants' profiles in a Massive Open Online Course (MOOC) are some of the main causes for a high dropout rate. International reports and research works points out the personalized learning as an important way to improve learning in any educational context. The information and communication technologies help to address adaptive technics in education through online courses. The specific characteristics of MOOCs point to the need to implement adaptive methodologies in MOOCs to increase the completion rates. This work presents a statistical analysis to find out in what aspects the condition of adaptivity, defined by the construct, is a preference of…
Revenue models, in-app purchase, and the app performance: Evidence from Apple's App Store and Google Play
2016
The effect of revenue models on app performance depends on the app store.The effect of in-app purchase on app performance depends on the app store.Paid, freemium and in-purchase models are shown to be effective in app store.Freemium and in-app purchase models are shown to be less effective in Google Play.App category influences the effects of both revenue models and in-app purchase. In this paper, we empirically examine how the revenue model (paid, free, or freemium) adopted for a given app affects the app revenue performance as measured by the app daily revenue rank. We also study the impact of in-app purchase on this measure of performance. Moreover, we study how such relationships are co…
Análisis de los factores determinantes de la lealtad hacia los servicios bancarios online
2011
ResumenEl rápido crecimiento de la banca online refleja las ventajas que ésta ofrece respecto a las sucursales convencionales. No obstante, son muchos los consumidores que todavía utilizan los servicios bancarios online de forma esporádica, fundamentalmente para la comprobación de saldos, evitando realizar transacciones con un mayor nivel de riesgo. El objetivo de este estudio es analizar los factores determinantes de la lealtad hacia los servicios bancarios online, a través de un modelo integrador de la influencia del riesgo percibido y la confianza en las webs bancarias con el marco conceptual de la Teoría del Comportamiento Planificado (TCP). La configuración del riesgo percibido se ha p…
Conductas sexuales online y sus motivaciones: Una aproximación desde la diversidad sexual
2020
El uso de Internet con objetivos sexuales (cibersexo) es una actividad cada vez más generalizada en todos los sectores de la población. Sin embargo, el modo en el que se realiza (frecuencia, tipos de actividad sexual online –ASO–, motivaciones, etc.) puede cambiar en función de características como la orientación sexual. Cuando el hecho de sentir atracción sexual hacia personas del mismo sexo suponía mayor rechazo y estigmatización que en la actualidad, el cibersexo constituía un espacio seguro donde experimentar con la sexualidad; así, era fácil comprender que su consumo entre personas homosexuales y bisexuales fuera superior. Actualmente, su empleo como espacio seguro parece quedar en seg…
Impacto del desempeño de los estudiantes en una metodología de evaluación continua en Moodle en el examen final
2017
Este trabajo examina la diferente evolución del rendimiento de los estudiantes en cuestionarios online y su impacto en la calificación final. Esta innovadora técnica se ha utilizado en un grupo de un curso introductorio de contabilidad financiera con 8 cuestionarios online (uno por unidad temática) a través de la plataforma Moodle. Empleando el análisis cluster, identificamos diferentes grupos de evolución del rendimiento. La evidencia obtenida sugiere que en uno de estos grupos una evolución favorable del rendimiento en los test online puede conducir a un exceso de confianza, con el posterior efecto negativo en la nota del examen final. La investigación futura con más variables y muestras …