Search results for " ovarian"

showing 10 items of 137 documents

Interstitial pregnancy in a patient with ipsilateral adnexal absence: Case report and literature review

2013

Unilateral ovarian absence (UOA) with fallopian tube absence is a rare condition. The true incidence is unknown. Here, we report a case of a woman with left tubal and ovarian absence, undergoing laparoscopy for an ipsilateral interstitial pregnancy (IP). The gestational mass was excided using the purse string technique to achieve better haemostasis. Probable etiologies are discussed and literature reviewed. According to our analysis the reproductive outcome of women affected by this rare anomaly is not compromised. Its impairment should be related to comorbidities or other unexplained causes. © Copyright 2014, CIC Edizioni Internazionali, Roma.

Ovarian agenesiAdnexal agenesiObstetrics and GynecologyPurse string techniqueUro-genital malformationFallopian tube absenceUnilateral ovarian absenceInterstitial pregnancy
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The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report.

2009

Abstract OBJECTIVE: To review all available data and recommend a definition for polycystic ovary syndrome (PCOS) based on published peer-reviewed data, whether already in use or not, to guide clinical diagnosis and future research. DESIGN: Literature review and expert consensus. SETTING: Professional society. PATIENTS: None. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): A systematic review of the published peer-reviewed medical literature, by querying MEDLINE databases, to identify studies evaluating the epidemiology or phenotypic aspects of PCOS. RESULT(S): The Task Force drafted the initial report, following a consensus process via electronic communication, which was then reviewed and c…

Ovulationmedicine.medical_specialtySettore MED/09 - Medicina Internaendocrine system diseasesMEDLINEPCOS Fertility Anovulation Menstrual irregularities Obesity Hyperandrogenism Ovarian function Ovarian ultrasoundsSettore MED/13 - EndocrinologiaDiagnosis DifferentialPredictive Value of TestsIntervention (counseling)Terminology as TopicEpidemiologymedicineHealth Status IndicatorsHumanshirsutismMenstruation DisturbancesOvarian Function TestsGynecologyEvidence-Based Medicinebusiness.industryHyperandrogenismOvaryObstetrics and GynecologyEvidence-based medicinemedicine.diseasePolycystic ovarySettore MED/40 - Ginecologia E Ostetriciafemale genital diseases and pregnancy complicationsPhenotypeReproductive MedicineFemalebusinessHyperandrogenismBiomarkersMedical literatureClinical psychologyPolycystic Ovary SyndromeFertility and sterility
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18P In vitro analysis of the combination of APR-246 and carboplatin in triple negative breast cancer (TNBC) and high grade serous ovarian cancer (HGS…

2021

P53 pathwaybusiness.industryHematologyCarboplatinIn vitro analysischemistry.chemical_compoundOncologychemistryCell cultureCancer researchSerous ovarian cancerMedicineAurora Kinase AbusinessTriple-negative breast cancerAnnals of Oncology
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Atypical presentation of anti-N-methyl-D-aspartate receptor encephalitis: two case reports

2017

Abstract Background Anti-N-methyl-D-aspartate receptor encephalitis is a rare autoimmune disease characterized by severe neurological and psychiatric symptoms and a difficult diagnosis. The disease is often secondary to a neoplastic lesion, seldom diagnosed years later. Psychiatric symptoms are prevalent in adults; neurologic symptoms are more evident in children, who typically present primarily with neurological symptoms. To the best of our knowledge, the association with juvenile idiopathic arthritis has not been described. Case presentation We report the cases of two caucasian girls with an atypical presentation. The first patient was an 8-year-old girl with normal psychomotor developmen…

PediatricsPathologyChoreiform movementAnti-Inflammatory AgentsArthritislcsh:MedicineCase ReportDisease0302 clinical medicinePrednisoneChildOvarian Neoplasms030219 obstetrics & reproductive medicineMedicine (all)Remission InductionTeratomaImmunoglobulins IntravenousGeneral MedicineMagnetic Resonance ImagingTreatment OutcomeMethylprednisoloneFemaleHip JointTeratomamedicine.symptomEncephalitismedicine.drugmedicine.medical_specialtyAdolescentAnti-N-methyl-D-aspartate receptor encephalitis; Chorea; Juvenile idiopathic arthritis; Psychiatric symptoms; Speech disorders; Teratoma; Medicine (all)Methylprednisolone03 medical and health sciencesJuvenile idiopathic arthritiChoreaPsychiatric symptomsmedicineHumansImmunologic FactorsAnti-N-methyl-D-aspartate receptor encephalitis; Chorea; Juvenile idiopathic arthritis; Psychiatric symptoms; Speech disorders; TeratomaAnti-N-methyl-D-aspartate receptor encephalitis; Chorea; Juvenile idiopathic arthritis; Psychiatric symptoms; Speech disorders; Teratoma; Adolescent; Anti-Inflammatory Agents; Anti-N-Methyl-D-Aspartate Receptor Encephalitis; Arthritis Infectious; Child; Female; Hip Joint; Humans; Immunoglobulins Intravenous; Immunologic Factors; Magnetic Resonance Imaging; Methylprednisolone; Ovarian Neoplasms; Remission Induction; Teratoma; Treatment Outcome; Medicine (all)Speech disorderSpeech disordersArthritis InfectiousPsychiatric symptombusiness.industrylcsh:RChoreaJuvenile idiopathic arthritismedicine.diseaseAnti-N-methyl-D-aspartate receptor encephalitisbusiness030217 neurology & neurosurgeryAnti-N-methyl-D-aspartate receptor encephaliti
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Out-of-the-box pelvic surgery including iliopsoas resection for recurrent gynecological malignancies: Does that make sense? A single-institution case…

2017

Abstract Objective To report morbidity and oncological outcomes in a consecutive series of lateral isolated recurrent gynecological cancer involving the pelvic side wall (PSW) including the iliopsoas muscle. Material and methods We retrospectively evaluated a consecutive series between 6/2013 and 12/2015 of lateral isolated recurrent gynecological malignancies treated with a lateral endopelvic resection (LEPR). LEPR was defined as an en-bloc lateral resection of a pelvic tumor with sidewall muscle, and/or bone, and/or major nerve, and/or major vascular structure. Post-surgical complications, quality of life (QoL) and survivals were computed. Results Seventy-four women with pelvic isolated r…

Pelvic NeoplasmPsoas MusclePostoperative Complications0302 clinical medicineQuality of lifeRetrospective StudieUterine NeoplasmPelvic Neoplasms030212 general & internal medicineIliopsoas resection; Lateral endopelvic resection; Pelvic side wall disease; Recurrent gynecological malignanciesPelvic NeoplasmsPsoas MusclesOvarian NeoplasmsPelvic side wall diseaseGraft Occlusion VascularPeripheral Nervous System DiseasesIliopsoas resectionGeneral MedicineMiddle AgedThrombosisCompartment SyndromeTreatment OutcomeOncology030220 oncology & carcinogenesisUterine NeoplasmsThrombosiFemaleIliopsoasHumanAdultmedicine.medical_specialtyIliopsoas MuscleIliopsoas resection; Lateral endopelvic resection; Pelvic side wall disease; Recurrent gynecological malignancies; Adult; Aged; Compartment Syndromes; Disease-Free Survival; Female; Graft Occlusion Vascular; Humans; Middle Aged; Muscle Skeletal; Neoplasm Recurrence Local; Ovarian Neoplasms; Pelvic Neoplasms; Peripheral Nervous System Diseases; Postoperative Complications; Psoas Muscles; Quality of Life; Retrospective Studies; Thrombosis; Treatment Outcome; Uterine Neoplasms; Surgery; OncologyCompartment SyndromesDisease-Free Survival03 medical and health sciencesmedicineHumansMuscle SkeletalRetrospective StudiesAgedbusiness.industryOvarian NeoplasmThrombosisRetrospective cohort studyPerioperativeRecurrent gynecological malignanciemedicine.diseaseSurgerySettore MED/40 - GINECOLOGIA E OSTETRICIAQuality of LifeLateral endopelvic resectionPelvic tumorSurgeryPostoperative ComplicationRecurrent gynecological malignanciesNeoplasm Recurrence LocalPeripheral Nervous System DiseasebusinessEuropean Journal of Surgical Oncology (EJSO)
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Quercetin and MicroRNA Interplay in Apoptosis Regulation in Ovarian Cancer

2020

The multifaceted nature of ovarian cancer has severely hampered the development of effective therapeutics over the years. The complicate nature of ovarian cancer makes it therapeutically challenging, therefore, there has been a renewed interest in phytochemistry. Phytochemicals have emerged as a potential therapeutic option due to less side effects. Moreover, the signaling inhibition properties have also been studied extensively in recent times. A growing number of data obtained via high-throughput technologies has started to delineate the complex oncogenic signaling networks, thus broadening the therapeutic opportunities. Within the network, microRNAs (miRNAs) have been shown to play a ve…

PhytochemicalsApoptosisCarcinoma Ovarian EpithelialBiologyTherapeutic approachchemistry.chemical_compoundOvarian cancerDrug DiscoveryOncogenic signalingmicroRNAmedicineHumansSettore BIO/06 - Anatomia Comparata E CitologiaCytotoxicityOvarian NeoplasmsPharmacologyChemo-preventive agentCancermedicine.diseaseMicroRNAschemistryApoptosismiRNAsCancer researchFemaleQuercetinOvarian cancerQuercetin
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Association of recurrent mutations in BRCA1, BRCA2, RAD51C, PALB2, and CHEK2 with the risk of borderline ovarian tumor.

2021

Abstract Background There are several genes associated with ovarian cancer risk. Molecular changes in borderline ovarian tumor (BOT) indicate linkage of this disease to type I ovarian tumors (low-grade ovarian carcinomas). This study determined the prevalence and association of mutations in BRCA1, BRCA2, PALB2, RAD51C, and CHEK2 with the risk of BOTs. Methods The study group consisted of 102 patients with histologically confirmed BOT and 1743 healthy controls. In addition, 167 cases with ovarian cancer G1 were analyzed. The analyses included genotyping of 21 founder and recurrent mutations localized in 5 genes (BRCA1, BRCA2, PALB2, RAD51C, and CHEK2). The risk for developing BOT and low-gra…

Recurrent mutationsBorderline ovarian tumorRAD51COncologyPALB2Low-grade ovarian cancerBRCA1BRCA2CHEK2Genetics (clinical)Hereditary cancer in clinical practice
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Role of Cytoreductive surgery in recurrent ovarian cancer

2010

Ovarian cancer is the leading cause of death from gynecologic malignancy in western countries, primarily because over 60% of patients with ovarian cancer will experience disease recurrence. Primary cytoreductive surgery and combination chemotherapy are the cornerstones of the initial treatment for epithelial ovarian cancer. The management of recurrent ovarian cancer is less clear than that of primary disease. The management of recurrent ovarian cancer is largely based on systemic chemotherapy, with surgery being offered only in selected individuals. Despite this, the benefits of surgery has been shown in a meta-analysis by Bristow et al. where the survival is influenced by the completeness …

Secondary cytoreductionOncologymedicine.medical_specialtyendocrine system diseaseshypertermic intraoperative peritoneal chemotherapyGynecologic oncology; HIPEC; Hyperthermic intraoperative peritoneal chemotherapy; Recurrent ovarian cancer; Secondary cytoreductionGinecologic oncology Hipec recurrent ovarian cancer secondary cytoreductionDiseaseGynecologic oncologyHyperthermic intraoperative peritoneal chemotherapyInternal medicinemedicinePharmacology (medical)Cause of deathHIPECbusiness.industrySystemic chemotherapyCombination chemotherapyGeneral Medicinemedicine.diseaseSettore MED/40 - Ginecologia E OstetriciaGynecologic oncologyGinecologic oncology Hipec recurrent ovarian cancer secondary cytoreduction; hypertermic intraoperative peritoneal chemotherapyRecurrent Ovarian CancerRecurrent ovarian cancerbusinessOvarian cancerCytoreductive surgery
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Laparoscopic surgical management of localized recurrent ovarian cancer: a single-institution experience

2014

Background: Optimally, secondary cytoreduction is acknowledged as a valid option in terms of oncologic outcome for patients with platinum-sensitive recurrent ovarian cancer. In cases of localized relapse, a laparoscopic approach has been attempted at various institutions, but studies on its role for this subset of patients still are limited. This report describes the authors' experience using laparoscopic secondary cytoreduction for patients with localized recurrent ovarian cancer. The results from a retrospective analysis of a prospective case series are reported. Methods: Between October 2011 and May 2013, 29 patients with localized recurrent ovarian cancer were selected for a laparoscopi…

Secondary cytoreductionmedicine.medical_treatmentTissue AdhesionsPostoperative ComplicationsLaparotomyLaparoscopyOvarian Neoplasmsmedicine.diagnostic_testMedicine (all)Middle Agedovarian cancerChemotherapy AdjuvantLymphatic MetastasisFemaleAdult; Aged; Antineoplastic Agents; Carcinoma; Chemotherapy; Adjuvant; Disease-Free Survival; Female; Follow-Up Studies; Humans; Laparoscopy; Laparotomy; Length of Stay; Lymph Node Excision; Lymphatic Metastasis; Middle Aged; Monitoring; Intraoperative; Neoplasm Recurrence; Local; Neoplasm Staging; Operative Time; Ovarian Neoplasms; Postoperative Complications; Retrospective Studies; Tissue AdhesionsAdultmedicine.medical_specialtyRecurrent ovarian cancer; Laparoscopy; Secondary cytoreductionOperative TimeAntineoplastic AgentsDisease-Free SurvivalLaparoscopicMonitoring IntraoperativeInternal medicineCarcinomamedicineHumansAgedNeoplasm StagingRetrospective StudiesLaparotomybusiness.industryGeneral surgeryCarcinomaRetrospective cohort studyLength of StayHepatologymedicine.diseaseSurgerySettore MED/40 - GINECOLOGIA E OSTETRICIARecurrent Ovarian CancerLymph Node ExcisionSurgeryLaparoscopyNeoplasm Recurrence LocalRecurrent ovarian cancerOvarian cancerbusinessFollow-Up StudiesAbdominal surgery
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Seasonal screening of AChE, GSH and gonad histology, in European sea bassDicentrarchus labraxL. reared in three different fish farms

2013

The aim of this work was to do a preliminary seasonal screening of ecotoxicological biomarkers in European sea bass Dicentrarchus labrax in three different fish farms, to know if the different location and typology can discriminate them. A set of selected biomarkers of xenobiotic exposure, such as acetylcholinesterase (AChE) activity, Glutathione (GSH) and gonad morphology were investigated seasonally in male European sea bass D. labrax (L.) reared in three different intensive farms: a land-based farm of cement tanks (T), an in-shore sea cages farm (C1) and an off-shore sea cages farm (C2). The results showed that both location and typology can discriminate AChE activity, GSH content and go…

Settore BIO/07 - EcologiaMaleGonadAchéanimal diseasesFish farmingZoologyAquaculturePlant ScienceBiochemistryAnalytical ChemistryEuropean sea bachemistry.chemical_compoundAquacultureGSHmedicineEuropean sea bass aquaculture AChE; GSH ovarian histologyAnimalsEuropean sea bassSea bassGonadsAnalysis of VariancebiologyAChE GSHbusiness.industryfungiOrganic Chemistryovarian histologyFishesGlutathionebiology.organism_classificationGlutathionelanguage.human_languageFisherymedicine.anatomical_structurechemistryAChE GSH; aquaculture; European sea bass; ovarian histologyAcetylcholinesteraselanguageAChEDicentrarchusXenobioticbusinessNatural Product Research
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