Search results for " place."
showing 10 items of 654 documents
Efficacy of a 12-Week Simeprevir Plus Peginterferon/Ribavirin (PR) Regimen in Treatment-Naïve Patients with Hepatitis C Virus (HCV) Genotype 4 (GT4) …
2017
Background HCV GT4 accounts for up to 20% of HCV infections worldwide. Simeprevir, given for 12 weeks as part of a 24- or 48-week combination regimen with PR is approved for the treatment of chronic HCV GT4 infection. Primary study objectives were assessment of efficacy and safety of simeprevir plus PR in treatment-naïve patients with HCV GT4 treated for 12 weeks. Primary efficacy outcome was sustained virologic response 12 weeks post-treatment (SVR12). Additional objectives included investigation of potential associations of rapid virologic response and baseline factors with SVR12. Methods This multicentre, open-label, single-arm study (NCT01846832) evaluated efficacy and safety of simepre…
Transizioni in periodi di incertezza. L’innovazione delle politiche regionali di governance per lo sviluppo auto sostenibile
2020
The basis of this contribution are a) the European Commission's regional innovation strategies for smart specialization (RIS3), b) the regional policies to combat the risk of decline and c) the governance model of Transition Management. Today the challenge consists in the validation of RIS3 even in the conditions of uncertainty exacerbated, for example, by the recent experience of COVID 19 as a global pandemic, trigger of the planetary economic and social decline. The guidance of the territorial transformations induced by RIS3 can be achieved with GIS technologies which, in turn, can constitute a single platform of the competent regional administration for urban and landscape planning. This…
EmoTIC: Impact of a game-based social-emotional programme on adolescents
2021
[EN] Introduction Technologies provide a brilliant opportunity to promote social-emotional competences, well-being and adjustment in adolescence. Game-based programmes and serious games are digital tools that pursue an educational goal in an attractive environment for adolescents. The purpose of this study was therefore to determine the effectiveness of emoTIC, a game-based social-emotional programme designed according to Mayer, Caruso, and Salovey's model of emotional intelligence. Materials and methods The participants were 119 adolescents between 11 and 15 years, randomly assigned to the experimental group and the control group. The adolescents completed questionnaires to assess their em…
Self-Efficacy, Planning, or a Combination of Both? A Longitudinal Experimental Study Comparing Effects of Three Interventions on Adolescents’ Body Fat
2016
Author(s): Luszczynska, Aleksandra; Hagger, Martin S; Banik, Anna; Horodyska, Karolina; Knoll, Nina; Scholz, Urte | Abstract: BackgroundThe superiority of an intervention combining two sets of theory-based behavior change techniques targeting planning and self-efficacy over an intervention targeting planning only or self-efficacy only has rarely been investigated.PurposeWe compared the influence of self-efficacy, planning, and self-efficacy+planning interventions with an education-based control condition on adolescents' body fat, assuming mediating effects of respective social cognitive variables and moderate-to-vigorous physical activity (MVPA). The moderating role of the built environment…
Predicting school students’ physical activity intentions in leisure-time and school recess contexts: Testing an integrated model based on self-determ…
2021
BackgroundIdentifying psychological correlates of children's physical activity intentions may signpost potentially modifiable targets for interventions aimed at promoting physical activity participation. School recess and leisure-time outside of school are appropriate contexts in which such interventions may be delivered. However, few studies have identified correlates of physical activity intentions in these environments. Examining correlates in these contexts may provide formative evidence on which to base interventions to promote physical activity.PurposeThe current study adopted an integrated theoretical model to test relations between motivational constructs from self-determination the…
Predictors of school students’ leisure-time physical activity : An extended trans-contextual model using Bayesian path analysis
2021
Abstract Background:The trans-contextual model (TCM) has been applied to identify the determinants of leisure-time physical activity participation in secondary school students. In the current study, the TCM was extended to include additional constructs that represent non-conscious, implicit processes that lead to leisure-time physical activity participation alongside the motivational and social cognition constructs from the TCM. The current study used baseline and follow-up data from an intervention study to test the extended TCM.Methods:The current study adopted a two-wave prospective design. Secondary-school students (N = 502) completed measures of perceived autonomy support from physical…
Large-scale effects of migration and conflict in pre-agricultural groups: Insights from a dynamic model.
2016
The debate on the causes of conflict in human societies has deep roots. In particular, the extent of conflict in hunter-gatherer groups remains unclear. Some authors suggest that large-scale violence only arose with the spreading of agriculture and the building of complex societies. To shed light on this issue, we developed a model based on operatorial techniques simulating population-resource dynamics within a two-dimensional lattice, with humans and natural resources interacting in each cell of the lattice. The model outcomes under different conditions were compared with recently available demographic data for prehistoric South America. Only under conditions that include migration among c…
Subjective well-being of elderly people in a social care home in the process of participation
2015
Elderly people feel isolated from their former living place and they need social pedagogical support in the course of integration in a social care home. The integration of elderly people in a social environment is made more difficult because of the possible necessity of participation in the social life. The theoretical analysis has resulted in doing research on the theoretical content of the process of aging as well as in defining well-being and participation indicators. The research has been done in order to broaden the participation possibilities in a social care home, and as a result of the integration process to achieve the elderly people’s subjective well-being.
Caracterización conductual y neuroinmune de la resiliencia al estrés social: Efectos reforzantes de la cocaína
2020
Numerosos estudios preclínicos han demostrado que el estrés social incrementa la vulnerabilidad a los efectos reforzantes de la cocaína. Sin embargo, los resultados obtenidos no son homogéneos, observándose siempre una subpoblación que no muestra dicho incremento. Utilizando el modelo de derrota social (DS) repetida en ratones, en este trabajo hemos querido caracterizar conductualmente a los ratones resilientes al incremento de los efectos reforzantes de la cocaína inducido por el estrés social. Utilizamos ratones adultos macho de la cepa C57/BL6 a los que sometimos al protocolo de DS repetida y tres semanas más tarde, realizamos el Condicionamiento de Preferencia de Lugar (CPL) inducido po…
P-70REPEATED SOCIAL STRESS REVERSED ETHANOL-INDUCED CONDITIONED PLACE AVERSION IN MALE MICE
2015
Exposure to stressors can produce behavioural and neurochemical adaptations that render individuals more prone to drug-seeking and drug-taking behaviours. It is well know that stress experiences are a risk factor for alcohol abuse in humans and recent studies in animal models reported that repeated social stress increased alcohol consumption. The aim of the present work is to evaluate the long-term …