Search results for " place"

Effects of repeated social defeat on adolescent mice on cocaine-induced CPP and self-administration in adulthood: integrity of the blood-brain barrier

2015

Social stress in adulthood enhances cocaine self-administration, an effect that has been related with an increase in extracellular signal-regulated kinase and p38α mitogen-activated protein kinase phosphorylation. A detrimental effect of cocaine on blood-brain barrier (BBB) integrity has also been reported. This study evaluates the effects of repeated social defeat (RSD) during adolescence on the reinforcing and motivational effects of cocaine in adult mice and the changes induced by RSD on BBB permeability. Cocaine self-administration, conditioned place preference and quantitative analysis of claudin-5, laminin, collagen-IV and IgG immunoreactivity took place 3 weeks after RSD. Mice social…

Rewarding Properties of Testosterone in Intact Male Mice

2000

The present study examined the rewarding properties of 4-androsten-17β-ol-3-one testosterone in intact male mice using the conditioned place preference (CPP) technique. In Experiment 1, the pharmacokinetics of 0.8 and 1.2 mg/kg of testosterone were studied to determine the most appropriate temporal interval to test behavior. Additionally, the locomotor activity was recorded to control a possible interfering effect on CPP. The maximum testosterone concentration was registered at 45 min of administration, and no effects on activity were found. In Experiment 2, three groups of male OF-1 mice received four pairings of the least-preferred compartment with testosterone (0.8, 1, or 1.2 mg/kg, SC) …

Viaggi e nuovi media tra mobilità fisiche e virtuali

2010

Cognitive structuring and placebo effect

2017

Abstract In much of the research concerning the placebo phenomenon, the idea that placebo effects may vary in strength depending on a patient's personal characteristics or traits has been investigated. Findings regarding possible personality differences in placebo response, however, are conflicting and non-systematic. In this article a new theoretical attempt to explain the placebo phenomenon is offered. The authors postulate that the power of the placebo effect is moderated by the extent of use of cognitive structuring, which in turn is influenced by the interaction between the individuals' level of need for cognitive closure and their ability to achieve this state. To test this assumption…

Valle Aurelia in Progress: planning for real experiment

2016

One week to change the identity of an open space in Rome, working with the students and the inhabitants

Land Snails as a Diet Diversification Proxy during the Early Upper Palaeolithic in Europe

2014

Despite the ubiquity of terrestrial gastropods in the Late Pleistocene and Holocene archaeological record, it is still unknown when and how this type of invertebrate resource was incorporated into human diets. In this paper, we report the oldest evidence of land snail exploitation as a food resource in Europe dated to 31.3-26.9 ka yr cal BP from the recently discovered site of Cova de la Barriada (eastern Iberian Peninsula). Mono-specific accumulations of large Iberus alonensis land snails (Ferussac 1821) were found in three different archaeological levels in association with combustion structures, along with lithic and faunal assemblages. Using a new analytical protocol based on taphonomic…

Perfil profesional de los agentes de empleo y desarrollo local en España

2010

Los Agentes de Empleo y Desarrollo Local (AEDL) son participantes activos en la formulación e implementación de las políticas locales de empleo y en todos aquellos aspectos asociados al Desarrollo Local y cuya finalidad principal es la inserción sociolaboral de los diferentes colectivos que buscan integrarse en el mercado de trabajo. Sin embargo, su trabajo está siendo escasamente reconocido en los ámbitos político, social y laboral y están siendo objeto de una legislación que los condena a la temporalidad, la dependencia política y la insuficiencia de recursos para actuar con eficiencia. El trabajo tiene por objeto el estudio del perfil del AEDL en una triple dimensión: laboral, formativa …

Pre-treatment with high doses of cocaine decreases the reinforcing effects of cocaine in the conditioned place preference paradigm.

2012

The aim of the present study was to determine if pre-exposure to high doses of cocaine can subsequently alter the rewarding effects of this drug. Adult male mice received a pretreatment of physiological saline, or 12.5 or 25 mg/kg of cocaine (one injection a day for five days). After an interval of six days without injections, the rewarding effects of low doses of cocaine (0.5, 1 or 1.5 mg/kg) were evaluated in the conditioned place preference (CPP) paradigm. Doses of 1 and 1.5 mg/kg induced a clear CPP in animals pre-treated with saline but were ineffective in those pre-treated with 25 mg/kg of cocaine. Only the dose of 1.5 mg/kg induced CPP in mice pre-treated with 12.5 mg/kg of cocaine. …

Design and interpret the place of present

2018

The contemporary landscape expresses in itself all the contradictions of present time, marked by the lack of a coherent thought about the transformation of places and of a clear aesthetic elaboration. So, the project must reflect not only on the relationship between man and landscape but above on the need to return to a way of dwelling that respects the places. Architecture plays a fundamental role in the reconstruction of coherence of places and reveals their beauty: through its forms, it can set up unprecedented stories of space in places in constant evolution. The thought from which the design process originates must involve the reading and interpretation of the existing places, and proc…

Attitudes of dental implantologists in Spain to prescribing antibiotics, analgesics and anti-inflammatories in healthy patients

2019

Background The implantologists frequently prescribe antibiotics, analgesics and anti-inflammatories in dental implant surgery. The aims of this study were to evaluate the attitudes of implantologists in Murcia (Spain) to prescribing antibiotics, analgesics and anti-inflammatories in healthy patients during different implant dentistry procedures, and to see how these are influenced by individual dentist’s academic level, professional experience, and ongoing training (attending courses or reading scientific literature on medication use) Material and Methods This cross-sectional study included a total of 200 implantologists from the Murcia area (Spain), who each completed a two-page questionna…