Search results for " present"
showing 10 items of 566 documents
Epistemic and didactic values of the demonstrative process in different cultures: a case study in Geometry with Chinese and Italian students
2011
中国现当代诗歌的西方视野
2018
Il volume, composto da saggi critici, presenta alcuni degli aspetti che caratterizzano il panorama della produzione poetica cinese contemporanea. Si muove sulla linea di una proposta metodologica di lettura e interpretazione critica della poesia cinese.
Dendritic cell aggresome-like-induced structure formation and delayed antigen presentation coincide in influenza virus-infected dendritic cells.
2005
Abstract Influenza virus infection induces maturation of murine dendritic cells (DCs), which is most important for the initiation of an immune response. However, in contrast to EL-4 and MC57 cells, DCs present viral CTL epitopes with a delay of up to 10 h. This delay in Ag presentation coincides with the up-regulation of MHC class I molecules as well as costimulatory molecules on the cell surface and the accumulation of newly synthesized ubiquitinated proteins in large cytosolic structures, called DC aggresome-like-induced structures (DALIS). These structures were observed previously after LPS-induced maturation of DCs, and it was speculated that they play a role in the regulation of MHC cl…
Characterization of lymphokine-mediated activation of macrophages for antigen presentation: studies with long-term cultured bone marrow-derived macro…
1984
In cultures of bone marrow (BM) supplemented with L cell-derived colony-stimulating factor a pure population of macrophages (M phi) differentiates, which can be further propagated with a doubling time of 3.8 days. "Young" BMM phi obtained on day 8 of culture were shown to act as antigen-presenting cells inducing the antigen-specific proliferation of the cloned T cell line ST2/K.9, whereas "old" M phi had lost this ability. However, at any time tested (up to 132 days) the presentation function of old BMM phi could be completely restored by pulsing the cells with lymphokines (LK). A duration of 11 hr for the LK-pulse was sufficient to trigger the M phi to exert an optimal presentation functio…
Una tabla inédita de Fernando Yáñez y nueva luz sobre su estancia en Almedina (1518-1525)
2020
The contribution presents a new acquisition for the catalog of Fernando Yáñez, a Holy Family dating back to 1523, shedding new light on the artist?s production in the third decade of the sixteenth century during his return to Almedina, his birthplace, in a time frame that divides the works for Valencia, like the retablo mayor for the city?s cathedral, from his altarpieces for Cuenca.
Immune Evasion Proteins Enhance Cytomegalovirus Latency in the Lungs
2009
ABSTRACT CD8 T cells control cytomegalovirus (CMV) infection in bone marrow transplantation recipients and persist in latently infected lungs as effector memory cells for continuous sensing of reactivated viral gene expression. Here we have addressed the question of whether viral immunoevasins, glycoproteins that specifically interfere with antigen presentation to CD8 T cells, have an impact on viral latency in the murine model. The data show that deletion of immunoevasin genes in murine CMV accelerates the clearance of productive infection during hematopoietic reconstitution and leads to a reduced latent viral genome load, reduced latency-associated viral transcription, and a lower inciden…
CD8 T Cells Control Cytomegalovirus Latency by Epitope-Specific Sensing of Transcriptional Reactivation
2006
ABSTRACT During murine cytomegalovirus (mCMV) latency in the lungs, most of the viral genomes are transcriptionally silent at the major immediate-early locus, but rare and stochastic episodes of desilencing lead to the expression of IE1 transcripts. This low-frequency but perpetual expression is accompanied by an activation of lung-resident effector-memory CD8 T cells specific for the antigenic peptide 168-YPHFMPTNL-176, which is derivedfrom the IE1 protein. These molecular and immunological findings were combined in the “silencing/desilencing and immune sensing hypothesis” of cytomegalovirus latency and reactivation. This hypothesis proposes that IE1 gene expression proceeds to cell surfac…
A tyrosinase nonapeptide presented by HLA-B44 is recognized on a human melanoma by autologous cytolytic T lymphocytes
1996
The human tyrosinase gene has been reported previously to code for two distinct antigens recognized on HLA-A2 melanoma cells by autologous cytolytic T lymphocytes (CTL). By stimulating lymphocytes of melanoma patient MZ2 with a subclone of the tumor cell line of this patient, we obtained a CTL clone that lysed this subclone but did not lyse other subcloncs of the Same melanoma cell line. The sensitive melanoma subclone was found to express a much higher level of tyrosinase than the others, suggesting that the antigen recognized bv the CTL might be encoded by tyrosinase. Transfection of a tyrosinase cDNA demonstrated that the CTL clone indeed recognized a tyrosinase product presented by HLA-…
Shaping women's agency through temporality in "The life and activity of the holy and blessed teacher Syncletica"
2020
The present article attempts to discuss the relationship between two female characters, Thecla and Syncletica, against the wider theoretical background of temporality as it was perceived and construed through literary texts. Syncletica is portrayed as a ‘disciple’ of Thecla. However, while the apocryphal Acts of Paul and Thecla appear to be pervaded with an eschatological expectation, the Life of Saint Syncletica shows signs of a different temporality. The detailed description of the whole life of Syncletica, with an emphasis on the course of illness, reveals a temporality more focused on the stages of life. Building on this evidence, I aim to identify a set of key features that…
El Teatro Principal de Valencia durante la temporada teatral 1875-1876
2021
El presente artículo revisa toda la actuación operística que hubo en Valencia durante la temporada de 1875 a 1876, la primera que coincide con la restauración de la monarquía de Alfonso XII. A través de la actividad que se produjo en el Teatro Principal de Valencia, examinamos toda la labor operística que hubo en esta ciudad, ya que fue el único lugar donde se representó ópera en Valencia. Una temporada marcada, sin duda alguna, por el estreno de la obra de Verdi, Aida. Un debut que fue posible gracias a la participación del tenor asturiano Lorenzo Abruñedo. Señalamos, asimismo, la importante presencia de la soprano Anna Romilda Pantaleoni, una de las cantantes más sobresalientes en aquel m…