Search results for " press"
showing 10 items of 4213 documents
Low levels of both xanthine dehydrogenase and of cellular retinol binding protein are responsible for retinoic acid deficiency in malignant human mam…
2009
The seeming impairment of retinoid metabolism in human breast tumor cells has been attributed to the lower expression of cellular retinol binding proteins (CRBPs), of alcohol/retinol dehydrogenases, or aldehyde/retinaldehyde dehydrogenases. In a previous study we indicated that xanthine dehydrogenase (XDH) is able to oxidize actively both all-trans-retinol (t-ROL) bound to the CRBP (holo-CRBP) and all-trans-retinaldehyde (t-RAL) to all-trans-retinoic acid (t-RA) in human mammary epithelial cells (HMEC). Since both XDH and CRBP are required for the biosynthesis of t-RA, we have inspected their bioavailability in both estrogen-responsive and nonresponsive human mammary epithelial cancer cells…
Nitrate and nitrite in the diet: How to assess their benefit and risk for human health
2015
Nitrate is a natural constituent of the human diet and an approved food additive. It can be partially converted to nitrogen monoxide, which induces vasodilation and thereby decreases blood pressure. This effect is associated with a reduced risk regarding cardiovascular disease, myocardial infarction, and stroke. Moreover, dietary nitrate has been associated with beneficial effects in patients with gastric ulcer, renal failure, or metabolic syndrome. Recent studies indicate that such beneficial health effects due to dietary nitrate may be achievable at intake levels resulting from the daily consumption of nitrate-rich vegetables. N-nitroso compounds are endogenously formed in humans. However…
Cardiorespiratory Fitness and the Risk of Serious Ventricular Arrhythmias: A Prospective Cohort Study.
2019
Cardiorespiratory fitness (CRF) is an established risk factor for cardiovascular disease outcomes. However, the relationship of CRF with risk of ventricular arrhythmias (VAs) is unknown. We aimed to assess the prospective association of CRF with the risk of serious VAs. Cardiorespiratory fitness, as measured by maximal oxygen uptake, was assessed using a respiratory gas exchange analyzer in 2299 middle-aged men in the Kuopio Ischemic Heart Disease prospective cohort. We corrected for within-person variability in CRF levels using data from repeated measurements 11 years apart. During median follow-up of 25.3 years (interquartile range, 18.7-27.2 years), 73 serious VAs were recorded. The age-…
Evolution des paysages Sahélines au cours des six dernières décennies dans la région de Niamey : de la disparition de la brousse tigrée à l'encroutem…
2010
In the Sahel, the rapid increase of the population during the last decades and the climate variation lead to an important environmental degradation. This work aims to measure the impacts of the human pressure on ecosystem during the six last decades. A diachronic cartography of a 100 km² area close to Niamey was done with aerial photographs (1950 and 1975) and GPS measurements (2009). Results showed that the tiger bush vegetation was completely cleared between 1950 and 2009 while the fallow decreases from 7 % to 1 %. In the sandy valley, the increase of cultivated fields from 20,7 % (1950) to 69,4 % (1975) favoured wind and water erosions which allowed surface soil crusting. Between 1975 an…
A methodological look at the controversy about the influence of salt intake on cardiovascular risk
2012
Cardiovascular diseases are a major cause of premature death and disability. They represent an extraordinarily strong financial burden upon health-care systems in ‘‘developed’’ countries. Elevated blood pressure is a major cause of cardiovascular disease. There is much evidence that cardiovascular risk increases from normal blood pressure (i.e., from 115/75 mmHg upwards) [1]. Overwhelming evidence shows that reducing salt intake from 9–12 g/day to 5–6 g/day lowers blood pressure [2]. Blood pressure is a surrogate endpoint, but may be related to a reduction of morbidity and mortality due to cardiovascular causes. Thus, intensive support and encouragement to cut down on the intake of salt in …
Economic Double Censorship
2020
This chapter explores the censorship impact generated by economic logic on the selection and coverage of topics in factual formats and current affairs documentaries on French television. This prelimina- ry research studies more specifically the subcontracting relationships between TV channels and production companies from semi- structured interviews with various categories of professionals (managers of TV press agencies, journalists, directors, Commissioning Editor). The analysis distinguishes two types of censorship ef- fects. The competitive relationships and the business models of the broadcasters condition their positions in the media field and thus exercise a structural censorship on t…
L’habitat du Néolithique final de Quinssaines, Le Bournadiau : approche spatiale et fonctionnelle d'un site au Nord-Ouest de l'Allier.
2011
A late Neolithic settlement was explored during excavations in the northeast of the Allier département, at Bournadiau near Quinsaines, in 2007. Despite erosion, the excavation revealed a ditch and traces of two buildings. The ceramic assemblage and the stone tool industry, partly imported from Grand Pressigny, illustrate the contacts between the inhabitants and the cultural groups from Western-Central (Artenac) and Northern France (Gord). An unusual deposit of seventeen Grand Pressigny flint objects, discovered in the foundations of a small building, provides information about the redistribution process of such products and shows that the site probably functioned in collaboration with the G…
Sex differences in correlates of intermediate phenotypes and prevalent cardiovascular disease in the general population
2015
Background: There are marked sex differences in cardiovascular disease (CVD) manifestation. It is largely unknown how the distribution of CVD risk factors or intermediate phenotypes explain sex-specific differences. Methods and Results: In 5000 individuals of the population-based Gutenberg Health Study, mean age 55 ± 11 years, 51% males, we examined sex-specific associations of classical CVD risk factors with intima-media thickness, ankle-brachial index, flow-mediated dilation, peripheral arterial tonometry, echocardiographic, and electrocardiographic variables. Intermediate cardiovascular phenotypes were related to prevalent CVD [coronary artery disease, heart failure, stroke, myocardial i…
Physiological parameters measurements in a cardiac cycle via a combo PPG-ECG system
2015
In this paper, we present an innovative way to measure some physiological parameters (such as the pre-ejection period, the pulse transit time, the blood pressure) in a cardiac cycle. A combo PPG-ECG system has been developed and employed to extract both the ECG signal from standard limb leads and simultaneously the photoplethysmography signal from the wrist and the forearm, to calculate the pre-ejection period. This system represents an easy and non-invasive technique to determine these biomedical parameters without using expensive impedance cardiography equipment.