Search results for " progress."

Regulatory cytokine gene polymorphisms and risk of colorectal carcinoma.

2006

It is well established that cancer arises in chronically inflamed tissue, and this is particularly notable in the gastrointestinal tract. Classic examples include Helicobacter pylori-associated gastric cancer, hepatocellular carcinoma, and inflammatory bowel disease-associated colorectal cancer. Growing evidence suggests that these associations might be not casual findings. Focusing on individual cytokines has generated evidence that anti-inflammatory cytokine interleukin (IL)-10 and transforming growth factor-beta1 (TGF-beta1) may have a complex role in gastrointestinal carcinogenesis. As an example, IL-10-deficient mice develop severe atrophic gastritis and a chronic enterocolitis, develo…

Time to ferry heart failure onto new shores: The need to effectively customize long-term therapy

2011

Cisplatin plus weekly vinorelbine versus cisplatin plus vinorelbine on days 1 and 8 in advanced non-small cell lung cancer: a prospective randomized …

2008

Summary Purpose A phase III randomized trial was carried out to compare two schedules of the vinorelbine (VNR)–cisplatin (CDDP) regimen in patients with locally advanced unresectable poor prognosis stage IIIB or metastatic stage IV non-small cell lung cancer. The primary endpoints were overall survival (OS) and analysis of toxicity, while secondary endpoints included response rates, time-to-progression (TTP) and quality of life (QoL). Patients and methods Eligible patients were randomized to receive: (a) VNR 25 mg/m 2 on day 1, 8 and 15 plus CDDP 100 mg/m 2 on day 1 every 4 weeks or (b) VNR 30 mg/m 2 on day 1 and 8 plus CDDP 80 mg/m 2 on day 1 every 3 weeks. All patients were chemotherapy-n…

Neoclassical Growth, Environment and Technological Change: The Environmental Kuznets Curve

2009

The paper investigates socially optimal patterns of economic growth and environmental quality in a neoclassical growth model with endogenous technological progress. In the model, the environmental quality affects positively not only to utility but also to production. However, cleaner technologies can be used in the economy whether a part of the output is used in environmentally oriented R&D. In this framework, if the initial level of capital is low then the shadow price of a cleaner technology is low relative to the cost of developing it given by the marginal utility of consumption and it is not worth investing in R&D. Thus, there will be a first stage of growth based only on the accumulati…

PNRR, lavoro pubblico e dintorni

2022

La legislazione di attuazione del PNRR contiene misure sul reclutamento e sulla progressione di carriera del personale pubblico, nonche´ sulla dirigenza, dirette allo scopo del rafforzamento della capacita` amministrativa delle istituzioni pubbliche. Esse presentano alcune luci e molte ombre su cui vale la pena soffermarsi. Peraltro, i grandi processi di trasformazione e transizione in atto reclamano un forte coinvolgimento delle parti sociali per garantire una loro gestione e una (auspicabile) crescita economica socialmente eque e sostenibili.

I valori etici e religiosi nell'economia secondo Giuseppe Toniolo

2010

Toniolo pone al centro del discorso economico l'uomo valorizzandone la dignità, la libertà, l'eguaglianza morale, la corresponsabilità e l'eticità.

EXPERIMENTAL INVESTIGATION OF DILUTE SOLID-LIQUID SUSPENSION IN AN UNBAFFLED STIRRED VESSELS BY A NOVEL PULSED LASER BASED IMAGE ANALYSIS TECHNIQUE

2009

The availability of experimental information on solid distribution inside stirred tanks is a topic of great importance in several industrial applications. The measurement of solid particle distribution in turbulent multiphase flow is not simple and the development of suitable measurement techniques is still in progress. In this work a novel non-intrusive technique for measuring particle concentration fields in solid-liquid systems is employed. The technique makes use of a laser sheet, a high sensitivity digital camera for image acquisition and a Matlab procedure for post-processing the acquired images. Experimental data are here obtained for the case of an unbaffled stirred tank. Stable tor…

A classical phenotype of Anderson-Fabry disease in a female patient with intronic mutations of the GLA gene: a case report

2012

Abstract Background Fabry disease (FD) is a hereditary metabolic disorder caused by the partial or total inactivation of a lysosomal hydrolase, the enzyme α-galactosidase A (GLA). This inactivation is responsible for the storage of undegraded glycosphingolipids in the lysosomes with subsequent cellular and microvascular dysfunction. The incidence of disease is estimated at 1:40,000 in the general population, although neonatal screening initiatives have found an unexpectedly high prevalence of genetic alterations, up to 1:3,100, in newborns in Italy, and have identified a surprisingly high frequency of newborn males with genetic alterations (about 1:1,500) in Taiwan. Case presentation We des…

Role of Type I and II Interferons in Colorectal Cancer and Melanoma

2017

Cancer can be considered an aberrant organ with a hierarchical composition of different cell populations. The tumor microenvironment, including the immune cells and related cytokines, is crucial during all the steps of tumor development. In particular, type I and II interferons are involved in a plethora of mechanisms that regulate immune responses in cancer, thus balancing immune escape versus immune surveillance. Interferons are involved in both the direct and indirect regulation of cancer cell proliferation and metastatic potential. The mutational background of genes involved in interferons signaling could serve as a prognostic biomarker and a powerful tool to screen cancer patients elig…

Reciprocal influence of B cells and tumor macro and microenvironments in the ApcMin/+ model of colorectal cancer

2017

One of the most fascinating aspects of the immune system is its dynamism, meant as the ability to change and readapt according to the organism needs. Following an insult, we assist to the spontaneous organization of different immune cells which cooperate, locally and at distance, to build up an appropriate response. Throughout tumor progression, adaptations within the systemic tumor environment, or macroenvironment, result in the promotion of tumor growth, tumor invasion and metastasis to distal organs, but also to dramatic changes in the activity and composition of the immune system. In this work, we show the changes of the B-cell arm of the immune system following tumor progression in the…