Search results for " progress."
showing 10 items of 1281 documents
Verbal learning and memory and their associations with brain morphology and illness course in schizophrenia spectrum psychoses.
2012
The California Verbal Learning Test and structural brain imaging were administered to 57 subjects with schizophrenia spectrum disorders and 94 controls in a general population sample. Cases had lower semantic cluster scores. Poorer verbal memory strategies were associated with longer duration of illness and heavier use of antipsychotic medication. After controlling for duration of illness, sex, and total gray matter, poorer verbal memory was associated with lower gray matter volume in the cingulate cortex, juxtapositional lobule, right superior temporal gyrus, and precuneus. After controlling for use of antipsychotic medication, there was an association between higher serial clustering and …
Loss of circadian clock gene expression is associated with tumor progression in breast cancer
2014
Several studies suggest a link between circadian rhythm disturbances and tumorigenesis. However, the association between circadian clock genes and prognosis in breast cancer has not been systematically studied. Therefore, we examined the expression of 17 clock components in tumors from 766 node-negative breast cancer patients that were untreated in both neoadjuvant and adjuvant settings. In addition, their association with metastasis-free survival (MFS) and correlation to clinicopathological parameters were investigated. Aiming to estimate functionality of the clockwork, we studied clock gene expression relationships by correlation analysis. Higher expression of several clock genes (e.g., C…
The arithmetic decomposition of central Cantor sets
2018
Abstract Every central Cantor set of positive Lebesgue measure is the arithmetic sum of two central Cantor sets of Lebesgue measure zero. Under some mild condition this result can be strengthened by stating that the summands can be chosen to be C s regular if the initial set is of this class.
Clinical relevance of genetic heterogeneity in HCV
2010
Infection by HCV affects an estimated 170 million people worldwide and it represents one of the major causes of liver transplantation and a heavy burden to healthcare systems. As with many other RNA viruses, HCV is characterized by very high levels of genetic variation, which have been associated to differences in disease progression and efficiency of antiviral treatment. Studies show many contradictory results and little consensus on such associations. Nevertheless, some general guidelines translating research results to clinical practice have been postulated. Here, we review the main research results obtained on HCV variation so far and explore the reasons for their lack of congruence und…
An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression.
2007
Colorectal cancer is a life-threatening disease that can develop spontaneously or as a complication of inflammatory bowel diseases. Mouse models are essential tools for the preclinical testing of novel therapeutic options in vivo. Here, we provide a highly reliable protocol for an experimental mouse model to study the development of colon cancers. It is based on the mutagenic agent azoxymethane (AOM), which exerts colonotropic carcinogenicity. Repeated intraperitoneal administration of AOM results in the development of spontaneous tumors within 30 weeks. As an alternative option, inflammation-dependent tumor growth can be investigated by combining the administration of AOM with the inflamma…
Proliferation state and polo-like kinase1 dependence of tumorigenic colon cancer cells.
2012
Abstract Tumor-initiating cells are responsible for tumor maintenance and relapse in solid and hematologic cancers. Although tumor-initiating cells were initially believed to be mainly quiescent, rapidly proliferating tumorigenic cells were found in breast cancer. In colon cancer, the proliferative activity of the tumorigenic population has not been defined, although it represents an essential parameter for the development of more effective therapeutic strategies. Here, we show that tumorigenic colon cancer cells can be found in a rapidly proliferating state in vitro and in vivo, both in human tumors and mouse xenografts. Inhibitors of polo-like kinase1 (Plk1), a mitotic kinase essential fo…
On a Linear Diophantine Problem of Frobenius: Extending the Basis
1998
LetXk={a1, a2, …, ak},k>1, be a subset of N such that gcd(Xk)=1. We shall say that a natural numbernisdependent(onXk) if there are nonnegative integersxisuch thatnhas a representationn=∑ki=1 xiai, elseindependent. The Frobenius numberg(Xk) ofXkis the greatest integer withnosuch representation. Selmer has raised the problem of extendingXkwithout changing the value ofg. He showed that under certain conditions it is possible to add an elementc=a+kdto the arithmetic sequencea,a+d,a+2d, …, a+(k−1) d, gcd(a, d)=1, without alteringg. In this paper, we give the setCof all independent numberscsatisfyingg(A, c)=g(A), whereAcontains the elements of the arithmetic sequence. Moreover, ifa>kthen we give …
In tema di inammissibilità del ricorso in cassazione relativo al difetto di giurisdizione non dedotto tra i motivi in sede d'appello
2003
Con la sentenza in commento la Cassazione si trova ad affrontare la questione circa i limiti di ammissibilità del ricorso in cassazione in relazione ai motivi dedotti in appello. In particolare si stabilisce come sia inevitabile una declaratoria di inammissibilità ove il difetto di giurisdizione venga dedotto per la prima volta con il ricorso, qualora nell'atto di appello non risultino censurate le valutazioni del fatto criminoso manifestate dal giudice di merito onde affermare la propria giurisdizione.
Traditional Chinese medicines (TCMs) for molecular targeted therapies of tumours.
2009
Scientific progress in genetics, cell and molecular biology has greatly ameliorated our comprehensive understanding of the molecular mechanisms of neoplastic transformation and progression. The rapidly advancing identification of molecular targets in human cancers during the last decade has provided an excellent starting point for the development of novel therapeutics. A huge variety of potential molecular targets have been identified, many of which are already in the market for therapeutic purposes. It is now becoming possible to target pathways and/or molecules that are crucial in maintaining the malignant phenotype. Traditional Chinese medicine (TCM) is often considered as alternative or…
Statistics-driven Development of OBD Systems: An Overview
2006
Automotive on-board diagnostic (OBD) systems are designed to keep critical components under control during vehicle functioning, and to alert the driver in case of severe malfunctions. OBD systems aimed at reducing polluting emissions are mandatory on new motor vehicles. Some research projects conducted in cooperation between universities and the automotive industry have been quite successful in terms of knowledge advancement and industrial gain. An updated overview of the adopted methodologies and results obtained are given in this article. Such results can be valuable for both theorists and practitioners, since they witness the use of statistics as a powerful catalyst of technical progress…