Search results for " progress"

Self-reported flares are predictors of radiographic progression in rheumatoid arthritis patients in 28-joint disease activity score remission: a 24-m…

2016

Background Disease flares are common in rheumatoid arthritis (RA) and are related to structural damage. However, few data on the impact of flares reported by patients on radiographic progression are available. Our aim was to investigate whether overall flares (OF), self-reported flares (SRF) and short flares assessed at the visit (SF) predict radiographic progression in RA patients in DAS28 (28-joint disease activity score) remission. Methods We reviewed the records of RA patients included in our database. We considered all patients who had a period of at least 24 months in remission (DAS28 0. Patients were assessed every 3 months and flares were recorded. We defined SRF as any worsening of…

Ortokeratoloģijas ietekme uz acs garuma un refrakcijas izmaiņām bērniem ar miopiju

2017

Darbs uzrakstīts angļu valodā uz 68 lapaspusēm, satur 17 attēlus, 10 tabulas un 73 literatūras atsauces. Darba mērķis bija salīdzināt acu aksiālā garuma un refrakcijas izmaiņas divām grupām tuvredzīgo jauniešu. Vienai grupai tuvredzība tika koriģēta ar ortokeratoloģiskajām kontaktlēcām (OK), bet otrajai ar brillēm. Pēc 18 mēnešiem tuvredzīgo pacientu grupai koriģētai ar brillēm acs aksiālais garums vidēji palielinājās par 0,20 mm, turpretī pacientiem koriģētiem ar OK kontaktlēcām tas bija tikai 0,05 mm. Pacientu grupai koriģētai ar OK kontaktlēcām tuvredzības pieaugums vidēji bija tikai -0,04 D, bet pacientiem koriģētiem ar brillēm tas bija -0,40 D. Refrakcijas izmaiņu atšķirība 0,36 D bija…

Ludus in Fabula: Music and Play in Stravinsky's "The Rake's Progress" (1951)

2009

Comparing Guidance via Implicit and Explicit Model Progressions in a Collaborative Inquiry-Based Learning Environment with Different-Aged Learners

2022

There is a need for research on the effect of different types of model progressions and learner age on learning and engagement in inquiry-based science settings. This study builds on the Scientific Discovery as Dual Search model to introduce less specific implicit model progression and compares them to the traditional explicit model progression. The data come from Finnish 8-, 10-, and 12-year-olds collaboratively using two different configurations of an inquiry-based learning environment about balance. Balance scale tasks were used to assess learning. Students also rated their situation-specific engagement. Both types of model progressions were beneficial for learning but there was no diffe…

Activation of the p38MAPK cascade is associated with upregulation of TNF alpha receptors in the spinal motor neurons of mouse models of familial ALS.

2005

Phosphorylated p38 mitogen-activated protein kinase (p38MAPK), but not activated c-jun-N-terminal kinase (JNK), increases in the motor neurons of transgenic mice overexpressing ALS-linked SOD1 mutants at different stages of the disease. This effect is associated with a selective increase of phosphorylated MKK3-6, MKK4 and ASK1 and a concomitant upregulation of the TNFalpha receptors (TNFR1 and TNFR2), but not IL1beta and Fas receptors. Activation of both p38 MAPK and JNK occurs in the activated microglial cells of SOD1 mutant mice at the advanced stage of the disease; however, this effect is not accompanied by the concomitant activation of the upstream kinases ASK1 and MKK3,4,6, while both …

Expression of p63, p53 and ki-67 in patients with cervical intraepithelial neoplasia

2017

Objective: Cervical intraepithelial neoplasia (CIN) is a dysplastic process in cervical squamous epithelium and carries a risk of progression to cervical cancer. The aim of this study was to compare expression of three biomarkers named p53, p63 and Ki-67 in patients with various grades of cervical intraepithelial neoplasia and in a control group. Material and Method: 58 patients were enrolled in the study. Each patient underwent a colposcopy-guided biopsy of the cervix. Immunostaining for markers (p53, p63 and Ki-67) was performed on tissue samples of normal cases (n=10), CIN I (n=20), CIN II (n=14), and CIN III (n=14). Results: Our study showed a significant increase of the expression of t…

Course and Predictors of Pain and Physical Functioning in Patients with Hip Osteoarthritis: Systematic Review and Meta-Analysis

2016

Objective: To systematically summarize the literature on: (i) the course of pain and physical functioning; and (ii) predictors of deterioration of pain and physical functioning in patients with osteoarthritis of the hip. Methods: A literature search was conducted in PubMed, CINAHL, Embase, PsychINFO and SPORTDiscus up to July 2015. Meta-analyses and qualitative data syntheses were performed. Results: Eleven of the 15 included studies were of high quality. With regard to the course of pain and physical functioning, high heterogeneity was found across studies (I2 >71%) and within study populations (reflected by large standard deviations of change scores). Therefore, the course of pain and phy…

Rola i znaczenie kształcenia zawodowego dla rozwoju przyszłych pokoleń Polaków

2020

Periodontitis and alzheimer´s disease

2020

Background Alzheimer's disease (AD), the main cause of dementia in the adult population, is characterized by a progressive loss of cognitive function. It is considered that neuroinflammation plays a fundamental role in its onset and progression. The bacteria present in the disbiotic microbiome generated during the course of periodontitis (PE) are capable of inducing a systemic inflammatory response, exacerbating the production of proinflammatory mediators that have the potential to spread to the systemic circulation. Material and Methods A literature review was made using the databases Scielo, PubMed, EBSCO and key words "Alzheimer disease", "Periodontitis", "Neurodegeneration", "Inflammati…

Dissemination/Communication Report. Period concerning this report: 01.01.2019-31.12.2019.

2019

During the second year of the project implementation different dissemination/communication activities were carried out. The scientific results of the project were presented on two conferences ICSAAM 2019, September 12-15, 2019 (Ischia, Italy) and DFMN 2019, November 19-22, 2019 (Moscow, Russia). Based on the conference presentation two conference full papers were prepared and submitted for the publication in conference proceedings having open access and indexed in Scopus. One scientific publication was published in the special issue of Polymers (Q1 open access journal, IF 3.2). For the dissemination of information among general public professional FACEBOOK profile was regularly updated with…