Search results for " project"
showing 10 items of 1296 documents
Comparison of HapMap and 1000 genomes reference panels in a large-scale genome-wide association study
2017
An increasing number of genome-wide association (GWA) studies are now using the higher resolution 1000 Genomes Project reference panel (1000G) for imputation, with the expectation that 1000G imputation will lead to the discovery of additional associated loci when compared to HapMap imputation. In order to assess the improvement of 1000G over HapMap imputation in identifying associated loci, we compared the results of GWA studies of circulating fibrinogen based on the two reference panels. Using both HapMap and 1000G imputation we performed a meta-analysis of 22 studies comprising the same 91,953 individuals. We identified six additional signals using 1000G imputation, while 29 loci were ass…
Managing expert knowledge in water network expansion project implementation
2021
[EN] The implementation of expansion projects of water networks supplying growing cities is deemed to be a complex decision-making problem involving both technical aspects and expert knowledge. Management and control processes must rely on experts in the field whose know-how must be coupled with techniques able to deal with the natural subjectivity that affects input evaluations. Given the presence of many decision-making elements, the choice of proper hydraulic technical parameters may be linked to the main aspects of analysis requiring formal expert evaluation. In this contribution, the simulation of hydraulic indicators is integrated with a multi-criteria approach able to eventually dete…
La mente in gioco. Percorsi didattici tra Neuroeducation e Video Education
2015
Il gioco svolge una funzione preziosa in tutte le fasi della vita, in quanto fa emergere le peculiari eccellenze personali di ciascuno. Il libro di Giuseppa Compagno e di Giuseppa Cappuccio indaga la dimensione educativa del gioco a partire da due dall'ambito della Neuroeducation e quello della Video education rispetto a due distinti angoli visuali: il mondo dei videogame con il comune intento di porre in risalto le potenzialità della pratica ludica e le possibili applicazioni metodologiche dell’utilizzo del gioco in campo pedagogico-didattico. Il libro fornisce non solo alcuni spunti utili ad una ricognizione sul gioco nella prospettiva brain-based e nell’ambito della Video Education ma pr…
β-Delayed and isomer spectroscopy of neutron-rich Ta and W isotopes
2009
Decays of neutron-rich A ~ 190 nuclei have been studied following projectile fragmentation of a 208Pb beam on a 9Be target at the GSI Fragment Separator. Gamma-ray decays from previously reported isomeric states in 188Ta, 190W and 192, 193Re were used as internal calibrations for the particle identification analysis, together with the identification of previously unreported isomeric decays in 189Ta and 191W. The current work also identifies β-delayed γ rays following the decay of 188Ta to 188W for the first time. Algora, Alejandro, Alejandro.Algora@ific.uv.es ; Molina Palacios, Francisco Manuel, Francisco.Molina@ific.uv.es; Rubio Barroso, Berta, Berta.Rubio@ific.uv.es
βDelayed γRay spectroscopy of heavy neutron rich nuclei “south” of lead
2009
Relativistic projectile fragmentation of a 208Pb primary beam has been used to produce neutron-rich nuclei with proton-holes relative to the Z = 82 shell closure, i.e., “south” of Pb. βDelayed γRay spectroscopy allows to investigate the structural properties of such nuclei with A ~ 195 → 205. The current work presents transitions de-exciting excited states in 204Au, which are the first spectroscopic information on this N = 125 isotone. Agramunt Ros, Jorge, Jorge.Agramunt@ific.uv.es ; Algora, Alejandro, Alejandro.Algora@ific.uv.es ; Molina Palacios, Francisco Manuel, Francisco.Molina@ific.uv.es ; Rubio Barroso, Berta, Berta.Rubio@ific.uv.es
Identification of susceptibility genes in non-syndromic cleft lip with or without cleft palate using whole-exome sequencing
2015
Background Non-syndromic cleft lip with or without cleft palate (NSCL/P) is among the most common congenital malformations. The etiology of NSCL/P remains poorly characterized owing to its complex genetic heterogeneity. The objective of this study was to identify genetic variants that increase susceptibility to NSCL/P. Material and Methods Whole-exome sequencing (WES) was performed in 8 fetuses with NSCL/P in China. Bioinformatics analysis was performed using commercially available software. Variants detected by WES were validated by Sanger sequencing. Results By filtering out synonymous variants in exons, we identified average 8575 nonsynonymous single nucleotide variants (SNVs). We subseq…
Mass and half-life measurements of neutron-deficient iodine isotopes
2020
The European physical journal / A 56(5), 143 (2020). doi:10.1140/epja/s10050-020-00153-5
Management and Control of the Read Out Processors (tpps) of the Aleph Time Projection Chamber
1989
The readout of the Aleph time projection chamber (TPC) relies on a set of 72 time projection processors (TPPs), which are based on a Motorola 68020 microprocessor running a real-time operating system. The advanced processing capabilities of the TPPs allow them to perform in parallel a number of tasks, both during and outside of data acquisition, which are outlined. The management and control of such a large number of intelligent devices is presented. The discussion covers the hardware configuration of the TPPs; the software running the TPPs; their management, status, and control; exception handling and message logging; and the TPP monitoring tasks. >
A Time Projection Chamber with GEM-Based Readout
2016
For the International Large Detector concept at the planned International Linear Collider, the use of time projection chambers (TPC) with micro-pattern gas detector readout as the main tracking detector is investigated. In this paper, results from a prototype TPC, placed in a 1 T solenoidal field and read out with three independent GEM-based readout modules, are reported. The TPC was exposed to a 6 GeV electron beam at the DESY II synchrotron. The efficiency for reconstructing hits, the measurement of the drift velocity, the space point resolution and the control of field inhomogeneities are presented.
The FIRST experiment at GSI
2012
The FIRST (Fragmentation of Ions Relevant for Space and Therapy) experiment at the SIS accelerator of GSI laboratory in Darmstadt has been designed for the measurement of ion fragmentation cross-sections at different angles and energies between 100 and 1000 MeV/nucleon. Nuclear fragmentation processes are relevant in several fields of basic research and applied physics and are of particular interest for tumor therapy and for space radiation protection applications. The start of the scientific program of the FIRST experiment was on summer 2011 and was focused on the measurement of 400 MeV/nucleon 12C beam fragmentation on thin (8 mm) graphite target. The detector is partly based on an alread…