Search results for " prospective"

showing 10 items of 244 documents

Cervical Spondylotic Myelopathy: When and Why the Cervical Corpectomy?

2020

Background: Cervical spondylotic myelopathy (CSM) is a degenerative disease that represents the most common spinal cord disorder in adults. The best treatment option has remained controversial. We performed a prospective study to evaluate the clinical, radiographic, and neurophysiologic outcomes for anterior cervical corpectomy in the treatment of CSM. Methods: From January 2011 to January 2017, 60 patients with CSM were prospectively enrolled in the present study. The patients were divided according to the modified Japanese Orthopaedic Association scale (mJOA) score into 2 groups: group A, patients with mild to moderate CSM (mJOA score ≥13); and group B, patients with severe myelopathy (mJ…

AdultMalemedicine.medical_specialtyRadiographymedicine.medical_treatmentSpinal Cord DisorderIntervertebral Disc DegenerationOssification of Posterior Longitudinal LigamentSeverity of Illness IndexMyelopathyYoung AdultDegenerative diseaseSpondylotic myelopathySymptom durationMedicineHumansProspective StudiesCorpectomyProspective cohort studyCervical corpectomy Young Adult Cervical spondylotic myelopathy Degenerative cervical myelopathy Surgical outcomes Adult Aged Cervical Vertebrae Decompression Surgical Functional Status Intervertebral Disc Degeneration Female Intervertebral Disc Displacement Humans Ossification of Posterior Longitudinal Ligament Middle Aged Male Prospective Studies Spinal Cord Compression Severity of Illness Index Treatment Outcome Spinal Fusion SpondylosisAgedbusiness.industryMiddle Agedmedicine.diseaseDecompression SurgicalSurgeryFunctional StatusSpinal FusionTreatment OutcomeCervical VertebraeSurgeryFemaleNeurology (clinical)SpondylosisbusinessSpinal Cord CompressionIntervertebral Disc DisplacementWorld neurosurgery
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Total body skin examination for skin cancer screening in patients with focused complaints

2012

Background. The value of total body skin examination (TBSE) for skin cancer screening is controversial. Objective: We sought to determine whether TBSE could be helpful in patients with focused skin symptoms who would not otherwise have undergone TBSE. Methods: In a prospective, multicenter, cross-sectional study consecutive adult patients were recruited during a period of 18 months. Physicians first inspected, problem areas and uncovered areas and then performed TBSE. Equivocal lesions detected in both steps were excised or biopsied. Primary outcomes were the absolute and relative risks of missing skin cancer and the number of patients needed to examine to detect melanoma or another maligna…

AdultMalemedicine.medical_specialtySkin NeoplasmsBiopsyprevalenceDermoscopyPhysical examinationDermatologydermatoscopyMalignancySkin Diseasesskin cancer; dermoscopy; prevention; prevalencetotal body skin examinationpreventionAdult; Aged; Biopsy; Cross-Sectional Studies; Dermoscopy; Early Detection of Cancer; Female; Humans; Male; Middle Aged; Physical Examination; Prospective Studies; Skin Diseases; Skin NeoplasmsBiopsymedicinemelanomaHumansProspective StudiesProspective cohort studyPhysical ExaminationEarly Detection of CancerAgedCross-Sectional StudieDermatoscopyintegumentary systemmedicine.diagnostic_testskin cancerbusiness.industrySkin DiseaseMelanomascreeningpigmented skin lesionsMiddle Agedmedicine.diseaseDermatologyProspective StudieCross-Sectional Studiestotal body skin examination; melanoma; skin cancer; preventionRelative riskFemalenonmelanoma skin cancerdermoscopySkin cancerbusinessHuman
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Patient and physician views on the quality of care in inflammatory bowel disease: Results from SOLUTION-1, a prospective IG-IBD study

2014

Remarkable differences in quality of care (QoC) might be observed in different countries, affecting quality of life of inflammatory bowel disease (IBD) patients. The aim of this study was to assess patient and physician perceptions of the QoC in Italy.A multicentre observational study on the quality of care in IBD (SOLUTION-1) was conducted in 36 IG-IBD (Italian Group for Inflammatory Bowel Disease) centres in Italy. The QUOTE-IBD (Quality of Care Through the Patient's Eyes) questionnaire was administered to IBD patients and to the attending physicians. The Quality Impact (QI) score summarises the QUOTE-IBD questionnaire, and a QI9 is considered satisfactory.Nine-hundred-ninety-two patients…

AdultMalemedicine.medical_specialtyquality impact score; quote-ibd; quality of careAdolescentAttitude of Health PersonnelQuality impact score; Quality of care; QUOTE-IBD; Adolescent; Adult; Aged; Aged 80 and over; Attitude of Health Personnel; Clinical Competence; Continuity of Patient Care; Female; Humans; Inflammatory Bowel Diseases; Italy; Male; Middle Aged; Patient Education as Topic; Patient Satisfaction; Professional Autonomy; Prospective Studies; Surveys and Questionnaires; Young Adult; Quality of Health Care; Medicine (all)Quality impact scoreGastroenterologyInflammatory bowel diseaseYoung AdultQUOTE-IBDPatient Education as TopicSurveys and QuestionnairesInternal medicineHealth care80 and overPhysician perceptionHumansMedicineProfessional AutonomyPharmaceutical SolutionsProspective StudiesQuality of careCompetence (human resources)AgedQuality of Health CareAged 80 and overbusiness.industryMedicine (all)Quality of careGastroenterologyQuality impact score; Quality of care; QUOTE-IBD; GastroenterologyGeneral MedicineContinuity of Patient CareMiddle AgedInflammatory Bowel Diseasesmedicine.diseasedigestive system diseasesItalyPatient SatisfactionFamily medicineFemaleContinuity of careObservational studyClinical CompetencebusinessJournal of Crohn's and Colitis
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Long-term outcome prediction by clinicopathological risk classification algorithms in node-negative breast cancer--comparison between Adjuvant!, St G…

2009

Background: Defining risk categories in breast cancer is of considerable clinical significance. We have developed a novel risk classification algorithm and compared its prognostic utility to the Web-based tool Adjuvant! and to the St Gallen risk classification. Patients and methods: After a median follow-up of 10 years, we retrospectively analyzed 410 consecutive node-negative breast cancer patients who had not received adjuvant systemic therapy. High risk was defined by any of the following criteria: (i) age 2 cm. All patients were also characterized using Adjuvant! and the St Gallen 2007 risk categories. We analyzed disease-free survival (DFS) and overall survival (OS). Results: The Node-…

AdultTime FactorsBreast NeoplasmsKaplan-Meier EstimateRisk AssessmentSensitivity and SpecificityDisease-Free SurvivalBreast cancerBreast cancer 3Predictive Value of TestsMedicineHumansLongitudinal StudiesProspective StudiesRisk factorAgedNeoplasm StagingRetrospective StudiesAged 80 and overNeovascularization Pathologicbusiness.industryHazard ratioCancerRetrospective cohort studyHematologyGenes erbB-2Middle Agedmedicine.diseasePrognosisImmunohistochemistrySurvival AnalysisTreatment OutcomeOncologyAdult; Aged; Aged 80 and over; Algorithms; Breast Neoplasms/genetics; Breast Neoplasms/pathology; Breast Neoplasms/radiotherapy; Breast Neoplasms/surgery; Disease-Free Survival; Female; Follow-Up Studies; Genes erbB-2; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Longitudinal Studies; Middle Aged; Multivariate Analysis; Neoplasm Staging; Neovascularization Pathologic; Predictive Value of Tests; Prognosis; Prospective Studies; Receptors Progesterone/analysis; Regression Analysis; Retrospective Studies; Risk Assessment; Sensitivity and Specificity; Survival Analysis; Time Factors; Treatment OutcomeMultivariate AnalysisRegression AnalysisFemaleBreast diseasebusinessRisk assessmentReceptors ProgesteroneAlgorithmAlgorithmsFollow-Up Studies
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Laparoscopic Radical Hysterectomy After Concomitant Chemoradiation in Locally Advanced Cervical Cancer: A Prospective Phase II Study

2015

Abstract Study Objective To assess the feasibility of total robotic radical surgery (TRRS) in patients with locally advanced cervical cancer (LACC) who receive chemoradiation therapy (CT/RT). Design A prospective (preplanned) study of a nonrandomized controlled trial (Canadian Task Force classification level 2). Setting Catholic University of the Sacred Hearth, Rome, Italy. Patients Between September 2013 and January 2016, a total of 40 patients with LACC (Federation Internationale de Gynecologie et d'Obstetrique stage IB2–III) were enrolled in the study. Interventions Robotic radical hysterectomy (RRH) plus pelvic and/or aortic lymphadenectomy was attempted within 6 weeks after CT/RT. The …

AdultUterine Cervical Neoplasmmedicine.medical_specialtymedicine.medical_treatmentUterine Cervical NeoplasmsHysterectomyPostoperative ComplicationsmedicineRadical hysterectomyHumansProspective StudiesCervical cancer; Laparoscopy; Neoadiuvant chemoradiation; Radical hysterectomy; Adult; Aged; Carcinoma; Squamous Cell; Chemoradiotherapy; Adjuvant; Cisplatin; Feasibility Studies; Female; Humans; Italy; Middle Aged; Neoadjuvant Therapy; Neoplasm Recurrence; Local; Postoperative Complications; Prospective Studies; Uterine Cervical Neoplasms; Hysterectomy; Laparoscopy; Lymph Node ExcisionRadical surgeryRadical HysterectomyProspective cohort studyNeoadjuvant therapyAgedCervical cancerHysterectomybusiness.industryMedicine (all)Obstetrics and GynecologyLaparoscopic Radical HysterectomyPerioperativeChemoradiotherapy AdjuvantMiddle Agedmedicine.diseaseNeoadjuvant TherapySurgeryFeasibility StudieProspective StudieSettore MED/40 - GINECOLOGIA E OSTETRICIAItalyCervical cancerNeoadiuvant chemoradiationCarcinoma Squamous CellFeasibility StudiesLymph Node ExcisionLymphadenectomyFemaleLaparoscopyPostoperative ComplicationCisplatinNeoplasm Recurrence LocalbusinessHuman
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Cancers in Patients with von Willebrand Disease: A Survey from the Italian Association of Haemophilia Centres

2015

Besides its essential role in hemostasis, there is growing evidence that von Willebrand factor (VWF) has an additional antitumor effect. To elucidate the clinical significance of this biological activity we conducted a retrospective study on cancers among Italian patients with von Willebrand disease (VWD) on behalf of the Italian Association of Haemophilia Centres (AICE). A questionnaire to collect demographic, clinical, and treatment data of VWD patients with cancer was sent to all the 54 Italian Haemophilia Treatment Centres (HTCs) members of AICE. Overall, 18 HTCs (33%) provided information on 92 VWD patients (61 alive and 31 deceased) with 106 cancers collected during the period 1981 to…

Adultcongenital hereditary and neonatal diseases and abnormalitiesPediatricsmedicine.medical_specialtySettore MED/09 - Medicina InternaPopulationbleeding; cancer; mortality; von Willebrand disease; Hematology; Cardiology and Cardiovascular MedicineHaemophiliaHospitals Specialbleeding; cancer; mortality; von Willebrand disease; Adult; Aged; Aged 80 and over; Humans; Italy; Middle Aged; Prospective Studies; Hospitals Special; Neoplasms; Surveys and Questionnaires; von Willebrand Diseases; Hematology; Cardiology and Cardiovascular MedicineVon Willebrand factorNeoplasmsSurveys and Questionnaireshemic and lymphatic diseases80 and overmedicineVon Willebrand diseaseHumanscancerProspective StudiesDesmopressinProspective cohort studyeducationAgedAged 80 and overeducation.field_of_studySpecialbiologybusiness.industryRetrospective cohort studyHematologyMiddle Agedmedicine.diseasebleedingmortalityHospitalsbleeding; cancer; mortality; von Willebrand disease; Adult; Aged; Aged 80 and over; Humans; Italy; Middle Aged; Prospective Studies; Hospitals Special; Neoplasms; Surveys and Questionnaires; von Willebrand Diseasesvon Willebrand DiseasesItalyHemostasisbiology.proteinbusinessvon Willebrand diseaseCardiology and Cardiovascular Medicinemedicine.drug
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Managing Adult-onset Still's disease: The effectiveness of high-dosage of corticosteroids as first-line treatment in inducing the clinical remission.…

2019

Abstract To assess the effectiveness of the treatment with high dosage of corticosteroids (CCSs), as first-line therapy, in inducing remission in naïve Adult-onset Still's disease (AOSD) patients compared with low dosage of CCSs, after 6 months. To further evaluate the rate of patients maintaining the remission and the rate of CCSs discontinuation, after additional 12 months of follow-up. A retrospective evaluation of patients prospectively followed was designed to compare the rate of clinical remission in naïve AOSD patients treated with high dosages of CCSs (0.8–1 mg/kg/day of prednisone-equivalent) or low dosage of CCSs (0.2–0.3 mg/kg/day of prednisone-equivalent), after 6 months. An add…

Adult-OnsetMalePediatricsAdult-onset Still's diseaseDiseaseAdrenal Cortex Hormonecorticosteroids0302 clinical medicinemonocyclic patternAdrenal Cortex HormonesRetrospective StudieMedicine030212 general & internal medicineProspective StudiesProspective cohort studyRemission InductionDisease ManagementGeneral MedicineMiddle AgedTreatment OutcomeHigh dosage030220 oncology & carcinogenesisFemaleDrugStill's Disease Adult-OnsetResearch ArticleHumanAdultcorticosteroidmedicine.medical_specialtyLow dosageObservational StudyAdult-onset Still's diseaseFollow-Up StudieDose-Response Relationship03 medical and health sciencesremissionAdult-onset Still's disease; corticosteroids; first-line therapy; monocyclic pattern; remission; Adrenal Cortex Hormones; Adult; Disease Management; Dose-Response Relationship Drug; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Remission Induction; Retrospective Studies; Still's Disease Adult-Onset; Treatment Outcomefirst-line therapyHumansRetrospective StudiesDose-Response Relationship Drugbusiness.industry6900Retrospective cohort studyStill's DiseaseFirst line treatmentSettore MED/16 - ReumatologiaProspective StudieMethotrexateObservational studybusinessFollow-Up Studies
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Gender differences in chronic liver diseases in two cohorts of 2001 and 2014 in Italy

2017

Background: Gender differences in chronic liver disease (CLD) have been partially investigated. To extend the present knowledge, we evaluated 12,263 patients with CLD enrolled in two national surveys (9997 in 2001 and 2557 in 2014). Methods: The two surveys prospectively recruited patients aged ≥ 18 referring to Italian liver units throughout the country using a similar clinical approach and analytical methods. Results: The overall male to female ratio (M/F) was 1.4 (7138/5124). Compared with females, males were significantly more likely to be younger (52.9 vs. 58.7 yrs.), with HBV infection alone (13.2% vs. 9.2%) and with alcoholic liver disease alone (11.4% vs. 6.9%), but less likely t…

Alcoholic liver diseasePathologyCirrhosisliver diseasesHepatocellular carcinomaPrevalenceChronic liver diseaseGastroenterology0302 clinical medicinecohort studiesEpidemiologymiddle aged030212 general & internal medicinehumansChronic liver diseasesHBV infectionChronic hepatitisadultChronic liver diseaseGeneral MedicineHepatitis CHepatitis BHCV infectionagedInfectious DiseasesItalyyoung adult030211 gastroenterology & hepatologyCohort studyMicrobiology (medical)medicine.medical_specialtyprevalence03 medical and health sciencesInternal medicinemedicineLiver Diseases AlcoholicAlcoholic liver diseases; Chronic hepatitis; Chronic liver diseases; HBV infection; HCV infection; Hepatocellular carcinoma; Microbiology (medical); Infectious DiseasesAlcoholic liver diseases; Chronic hepatitis; Chronic liver diseases; HBV infection; HCV infection; Hepatocellular carcinomabusiness.industryAlcoholic liver diseaseAlcoholic liver diseasesmedicine.diseaseprospective studiessex factorsChronic hepatitihepatitis Bhepatitis Cbusinesschronic diseasealcoholic liver diseases; chronic hepatitis; chronic liver diseases; HBV infection; HCV infection; hepatocellular carcinoma; adult; aged; chronic disease; cohort studies; hepatitis B; hepatitis C; humans; Italy; liver diseases; liver diseases alcoholic; middle aged; prevalence; prospective studies; sex factors; young adultalcoholic
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Fissurectomy and anoplasty in posterior normotensive chronic anal fissure.

2021

Purpose: Anal Fissure (AF) is the second most frequent proctological disease in Italy. Chronic AF (CAF) most common located at the posterior anal commissure (CAPF). CAPF are thought to be associated with hypertonic internal anal sphincter (IAS) but manometric findings showed that a normotonic IAS is present in the 20-40%. Sphincterotomy is often recommended as treatment of choice for CAF independently from IAS tone; nevertheless, this approach appears less logical for CAF with normotonic IAS, as in those cases there’s a higher risk of post-operative anal incontinence. The aim of this study is to evaluate the results of fissurectomy and anoplasty with V-Y cutaneous advancement flap, as treat…

Anal fissure; Anoplasty; Fissurectomy; Proctology; Sphincterectomy; Chronic Disease; Humans; Prospective Studies; Treatment Outcome; Digestive System Surgical Procedures; Fissure in AnoTreatment Outcomeanal fissuresphincterectomyChronic DiseaseHumansfissurectomyOriginal ArticleanoplastyFissure in AnoProspective StudiesproctologyDigestive System Surgical ProceduresActa bio-medica : Atenei Parmensis
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Association of plasma markers of cholesterol homeostasis with metabolic syndrome components. A cross-sectional study.

2011

Abstract Background and aims Increased plasma phytosterols, which reflect enhanced cholesterol absorption, have been related to an increased risk of cardiovascular disease (CVD). However, high CVD risk conditions, such as obesity, diabetes and the metabolic syndrome (MetS) have been associated with reduced cholesterol absorption. We investigated associations between plasma noncholesterol sterols and MetS components. Methods and results With a cross-sectional design, we related MetS components to plasma noncholesterol sterol-to-cholesterol ratios measured by gas chromatography in 674 dyslipidemic patients and 361 healthy subjects participating in a prospective cohort study. Plasma phytostero…

Apolipoprotein EAdultMalemedicine.medical_specialtyGenotypeEndocrinology Diabetes and MetabolismMedicine (miscellaneous)LathosterolBiologychemistry.chemical_compoundHigh-density lipoproteinApolipoproteins ERisk FactorsInternal medicineDiabetes mellitusmedicineHomeostasisHumansProspective StudiesProspective cohort studyMetabolic SyndromeNutrition and DieteticsPhytosterolsOdds ratioMiddle Agedmedicine.diseaseLipid MetabolismSitosterolsEuropean Prospective Investigation into Cancer and NutritionEndocrinologyCholesterolCross-Sectional StudiesPhenotypechemistryCardiovascular Diseaseslipids (amino acids peptides and proteins)FemaleMetabolic syndromeCardiology and Cardiovascular MedicineBiomarkersNutrition, metabolism, and cardiovascular diseases : NMCD
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