Search results for " prostate"
showing 10 items of 177 documents
Parathyroid hormone-related protein (PTHrP)-dependent modulation of gene expression signatures in cancer cells
2022
PTHrP is encoded by PTHLH gene which can generate by alternative promoter usage and splicing mechanisms at least three mature peptides of 139, 141 and 173 amino acids with distinct carboxy terminus. PTHrP may undergo proteolytic processing into smaller bioactive forms, comprising an amino terminus peptide, which is the mediator of the "classical" PTH-like effect, as well as midregion and carboxy terminus peptides that act as multifaceted critical regulator of proliferation, differentiation and apoptosis via the reprogramming of gene expression in normal and neoplastic cells. Moreover, a nuclear/nucleolar localization signal sequence is present in the [87-107] domain allowing PTHrP nuclear i…
Discovery of SI 1/20 and SI 1/22 as Mutual Prodrugs of 5-Fluorouracil and Imidazole-Based Heme Oxygenase 1 Inhibitor with Improved Cytotoxicity in DU…
2023
: In this work, we extend the concept of 5-fluorouracil/heme oxygenase 1 (5-FU/HO-1) inhibitor hybrid as an effective strategy for enhancing 5-FU-based anticancer therapies. For this purpose, we designed and synthesized new mutual prodrugs, named SI 1/20 and SI 1/22, in which the two active parent drugs (i. e., 5-FU and an imidazole-based HO-1 inhibitor) were connected through an easily cleavable succinic linker. Experimental hydrolysis rate, and in silico ADMET predictions were indicative of good drug-likeness and pharmacokinetic properties. Novel hybrids significantly reduced the viability of prostate DU145 cancer cells compared to the parent compounds 5-FU and HO-1 inhibitor administered…
Apoptosis induction of essential oils from Artemisia arborescens L. in human prostate cancer cells
2023
Ethnopharmacological relevance: Prostate cancer originates from cells inside a gland, which begin to grow out of control. In the world, prostate cancer is the most common cancer in the male population. New therapeutic strategies are needed for this tumor which still has a high mortality. A. arborescens leaves and aerial parts have various ethnopharmacological uses such as anti-spasmodic, and their decoctions were used to resolve urticaria, neuralgia and several lung diseases. Often this species has been also used to treat different inflammatory-related diseases such as cancer. Aim of the study: In a continuation of our research on essential oils from medicinal plants, we have selected, two …
Fiziskās aktivitātes inducēto ekstracelulāro vezikulu ietekme uz priekšdziedzera audzēja attīstību žurkās
2022
Priekšdziedzera vēzis (PV) ir viens no biežāk sastopamajiem ļaundabīgā audzēja veidiem vīriešiem, un, lai uzlabotu terapijas efektivitāti un pacientu dzīves kvalitāti, viens no līdzekļiem varētu būt regulāra fiziska aktivitāte. Ekstracelulārās vezikulas (EV) tiek uzskatītas par vienu no būtiskākajiem starpšūnu komunikācijas veidiem, un vairāki pētījumi ir parādījuši, ka to produkcija tiek inducēta fiziskās aktivitātes laikā. Šajā pētījumā tika noteikta fiziskās slodzes laikā veidojušos EV RNS profila izmaiņas, kā arī šo EV ietekme uz PV attīstību metastātiskā žurku PV modelī. Tika atrasti 20 diferenciāli ekspresēti gēni salīdzinot EV RNS saturu pirms un pēc slodzes, un 52 – salīdzinot aktīv…
Hemoglobīna līmeņa izmaiņas pirms un pēc operācijas, salīdzinot laparoskopisku un vaļēju retropubikālu radikālu prostatektomiju
2021
Primāri diagnosticēts prostatas vēzis stabili ieņem pirmo vietu aiz ne-melanocītiskā ādas audzēja vīriešiem ne tikai Latvijā, bet arī Eiropā. 2018.gadā veiktajā pētījumā apstiprinājās, ka prostatas vēzis ieņem pirmo vietu starp visām diagnosticētajām onkoloģiskajām slimībām Eiropā. Prostatas vēža incidence strauji palielinās līdz ar vecumu – ja 40-44 gadu vecumā prostatas vēzis tiek diagnosticēts 9.2 vīriešiem uz 100`000 iedzīvotājiem, tad jau 70-74 gadu vecumā incidence palielinās vairāk kā 100 reizes līdz pat 984.8 vīriešiem uz 100`000 iedzīvotājiem. Pētījuma galvenais mērķis bija noskaidrot vai dažādi operācijas veidi ietekmē intraoperatīvās asiņošanas risku un tādā veidā sekmē lielāku h…
Studio pilota sul valore predittivo dei livelli plasmatici di 9 fattori angiogenetici nella selezione di pazienti candidati alla biopsia prostatica
2013
To reduce the number of negative prostate biopsies in patients with elevated PSA serum levels represents a major challenge in urological oncology. Angiogenetic factors might be involved in initial stages of prostate cancer and might represent useful tools in patients' selection for prostate biopsy. The plasmatic levels of Angiopoietin-2, Follistatin, G-CSF, HGF, IL-8, Leptin, PDGF-BB, PECAM-1 and VEGF were measured by BioPlex immunoassay in patients undergoing prostate biopsy for palpable prostate nodule and/or elevated PSA levels (≥4 ng/mL). They were related with biopsy results. ROC curve analysis was exploited to test the diagnostic accuracy of each biomarker by AUC calculation. A potent…
Titanate nanotubes as versatile nanovectors : radiosensitizers for the treatment of prostate cancer and nuclear imaging probes
2017
Currently, the systemic injections of drugs reach very weakly tumor sites and large doses are thus administered causing adverse side effects. The new implementations of nanoparticles in the medical field offer new strategies to vectorize an active substance in diseased cells. This work is focused on the prostate cancer, which is the second most frequently diagnosed cancer and the fifth leading cause of cancer death in men worldwide.Titanate nanotubes (TiONts) are synthetized by a hydrothermal process and have average dimensions of about 170 nm in length, 10 nm in outer diameter and also have an internal cavity of 4 nm in diameter. Their needle-shaped morphology allows them to be internalize…
Computer-Aided Diagnosis for Prostate Cancer using Multi-Parametric Magnetic Resonance Imaging
2016
Prostate cancer (CaP) is the second most diagnosed cancer in men all over the world.CaP growth is characterized by two main types of evolution: (i) the slow-growing tumours progress slowly and usually remain confined to the prostate gland; (ii) the fast-growing tumours metastasize from prostate gland to other organs, which might lead to incurable diseases.Therefore, early diagnosis and risk assessment play major roles in patient treatment and follow-up.In the last decades, new imaging techniques based on Magnetic Resonance Imaging (MRI) have been developed improving diagnosis.In practise, diagnosis can be affected by multiple factors such as observer variability and visibility and complexit…
Factors predicting continence recovery 1 month after radical prostatectomy: Results of a multicenter survey
2011
Objectives: To assess the factors associated with continence recovery 1month after radical prostatectomy (RP) and to identify the correlation between these factors. Methods: In total, 2408 men treated with RP for prostate cancer (PCa) were enrolled in the present multicenter prospective study. Clinical (age, body mass index) and urological (catheterization or transurethral resection of the prostate) records, quality of life (QOL) scores determined using various instruments (including the International Index of Erectile Function [IIEF] and University of California Los Angeles, Prostate Cancer Index [UCLA-PCI]), PCa characteristics (clinical stage [cT], prostate-specific antigen, biopsy Gleas…
Identification of Prostate-Enriched Proteins by In-depth Proteomic Analyses of Expressed Prostatic Secretions in Urine
2012
Urinary expressed prostatic secretion or "EPS-urine" is proximal tissue fluid that is collected after a digital rectal exam (DRE). EPS-urine is a rich source of prostate-derived proteins that can be used for biomarker discovery for prostate cancer (PCa) and other prostatic diseases. We previously conducted a comprehensive proteome analysis of direct expressed prostatic secretions (EPS). In the current study, we defined the proteome of EPS-urine employing Multidimensional Protein Identification Technology (MudPIT) and providing a comprehensive catalogue of this body fluid for future biomarker studies. We identified 1022 unique proteins in a heterogeneous cohort of 11 EPS-urines derived from …