Search results for " protocol"
showing 10 items of 1320 documents
The hard road to data interpretation: 3 or 6 months of adjuvant chemotherapy for patients with stage III colon cancer?
2019
Background Six months of adjuvant oxaliplatin-based chemotherapy is standard for patients with stage III colon cancer following surgery. However, oxaliplatin is associated with peripheral neurotoxicity which worsens over treatment duration. Consequently, a shorter treatment duration, if equally effective, would be extremely beneficial. A pooled analysis of data for 12 834 stage III colon cancer patients, from six randomised phase III trials of adjuvant therapy, the International Duration Evaluation of Adjuvant chemotherapy study, was carried out and the results presented at the ASCO Annual Meeting 2017. To clarify the potential impact of these results on clinical practice, ESMO decided to s…
MAGA: A Supervised Method to Detect Motifs From Annotated Groups in Alignments
2020
Multiple sequence alignments are usually phylogenetically driven. They are studied in the framework of evolution. But sometimes, it is interesting to study residue conservation at positions unconstrained by evolutionary rules. We present a supervised method to access a layer of information difficult to appreciate visually when many protein sequences are aligned. This new tool (MAGA; http://cbdm-01.zdv.uni-mainz.de/~munoz/maga/ ) locates positions in multiple sequence alignments differentially conserved in manually defined groups of sequences.
An Internet-based treatment for flying phobia (NO-FEAR Airlines): study protocol for a randomized controlled trial
2016
Background: Flying phobia (FP) is a common and disabling mental disorder. Although in vivo exposure is the treatment of choice, it is linked to a number of limitations in its implementation. Particularly important, is the limited access to the feared stimulus (i.e., plane). Moreover, the economic cost of in vivo exposure should be specially considered as well as the difficulty of applying the exposure technique in an appropriate way; controlling important variables such as the duration of the exposure or the number of sessions. ICTs could help to reduce these limitations. Computer-assisted treatments have remarkable advantages in treating FP. Furthermore, they can be delivered through the I…
Idiopathic Environmental Intolerance: A Treatment Model
2021
Idiopathic environmental intolerance (IEI) refers to a health condition characterized by the presence of multiple symptoms in different organ systems in response to a variety of environmental cues, such as chemical exposures, electromagnetic radiation, infrasound from windmill farms, (parts of) buildings, foods, etc. Typically, the symptoms arise in response to triggers and at dosages that do not cause symptoms in the majority of people, and no clear link with any physiological dysfunction can be found. The condition varies in a dimensional way from very mild, for which no medical help is sought, to very disabling, compromising normal life. The condition is controversial, but several indica…
Retrieving Monitoring and Accounting Information from Constrained Devices in Internet-of-Things Applications
2013
Part 6: Monitoring Mechanisms; International audience; Internet-of-Things (IoT) is envisioned to provide connectivity to a vast number of sensing or actuating devices with limited computational and communication capabilities. For the organizations that manage these constrained devices, the monitoring of each device’s operational status and performance level as well as the accounting of their resource usage are of great importance. However, monitoring and accounting support is lacking in today’s IoT platforms. Hence, this paper studies the applicability of the Constrained Application Protocol (CoAP), a lightweight transfer protocol under development by IETF, for efficiently retrieving monito…
Safety Protocols for Forensic Inspections in the Time of COVID-19: An Approach to Protect Practitioners
2022
The COVID-19 pandemic has impacted the entire world in ways that were unimaginable in 2019. It has changed how professionals work and interact with one another. To ensure the safety of experts and attorneys, forensic inspection procedures must evolve while still providing a reliable foundation for expert testimony. Traditional field inspections require attendees to be physically present and in generally close proximity. Inspecting artifacts may also require that individual components be serially examined by multiple experts, which increases the risk of transmitting the disease. The authors propose a new approach to forensic inspections aimed at protecting consultants from the biological ris…
Contributions to Phase Two of AGATA electronics
2020
En el campo de la física nuclear, la espectroscopia de rayos gamma de alta resolución es un método preciso para estudiar la estructura del núcleo, extrayendo la energía y la distribución angular de los fotones gamma emitidos en las transiciones entre estados nucleares. Para obtener núcleos en un estado excitado y por tanto emitan rayos gamma, hemos de hacer chocar la materia, produciendo reacciones nucleares (espectroscopia de haz) o recurrir a desintegraciones radiactivas (espectroscopia de desintegración). Los detectores de semiconductor de germanio de alta pureza (HPGe) han demostrado tener una buena respuesta interaccionando con rayos gamma. Al igual que otros detectores de basados en s…
Efficacy of an internet-based psychological intervention for problem gambling and gambling disorder: study protocol for a randomized controlled trial
2021
Gambling Disorder is a prevalent non-substance use disorder, which contrasts with the low number of people requesting treatment. Information and Communication Technologies (ICT) could help to enhance the dissemination of evidence-based treatments and considerably reduce the costs. The current study seeks to assess the efficacy of an online psychological intervention for people suffering from gambling problems in Spain. The proposed study will be a two-arm, parallel-group, randomized controlled trial. A total of 134 participants (problem and pathological gamblers) will be randomly allocated to a waiting list control group (N = 67) or an intervention group (N = 67). The intervention program i…
Two New Alternatives to the Conventional Arm-in-Cage Test for Assessing Topical Repellents
2021
Abstract European guidelines for testing attractant and repellent efficacy (i.e., Product type 19 [PT19]) have been in revision since 2017. A key topic of discussion is the current approach to evaluating topical repellents. The European Chemical Agency has stated field testing should be avoided because of mosquito-borne disease risks. However, the most common laboratory method, the arm-in-cage (AIC) test, may limit the reliable extrapolation of lab results to field conditions. This study’s main goal was to assess alternative laboratory methods for evaluating topical mosquito repellents that use mosquito landing rates more representative of those in the field. The study took place at three E…
An in-depth evaluation of acalabrutinib for the treatment of mantle-cell lymphoma
2020
Introduction: Regimens involving intensive immuno-chemotherapy, followed by high-dose therapy and autologous stem cell transplant represent the standard treatment for younger fit patients with mantle cell lymphoma (MCL). Targeted approaches (i.e. ibrutinib, bortezomib, and lenalidomide) represent the backbone of therapy for relapsed cases. Areas covered: Acalabrutinib is a novel small molecule with a butynamide moiety specifically designed to irreversibly inhibit Bruton tyrosine kinase (BTK), which is more potent and selective than ibrutinib. Relevant publications have been identified through literature searches using the terms 'mantle cell lymphoma' and 'acalabrutinib'. Expert opinion: Aca…