Search results for " protocol"
showing 10 items of 1320 documents
Description of the response of a new multi-parametric brain sensor to physiological and pathophysiological challenges in the cortex of juvenile pigs
2014
AIM Monitoring of intracranial pressure (ICP), local cerebral blood flow (CBF) and oxygen is part of modern intensive critical care medicine. Preclinical evaluation of newly developed catheters that should monitor several parameters simultaneously is reported poorly in the literature. The goal of our study was (1) to evaluate a new multi-parametric sensor in brain tissue and (2) to establish a testing protocol using pathophysiological challenges that target measured parameters of the sensor and autoregulatory boundaries and could be used as preclinical standard protocol in future studies. MATERIAL AND METHODS We describe data from 12 new multi-parametric brain sensors (MPBS) that were impla…
Mutual entity authentication for LTE
2011
In this paper we outline the Authentication and Key Agreement protocol (EPS-AKA) found in Long-Term Evolution (LTE) systems. This architecture is the 3GPP version of a 4G access security architecture. The LTE security architecture is a mature evolved architecture, with both strengths and weaknesses. In this paper we propose an amendment to the EPS-AKA protocol to make it a full mutual (online) entity authentication protocol. We also analyze the proposal, highlighting both the improvements and the drawbacks of the new AKA protocol.
Tumorregression maligner Aderhautmelanome nach Transpupillarer Thermotherapie (TTT) versus Ruthenium-Brachytherapie und Sandwichtherapie – eine vergl…
2010
PURPOSE: The aim of this study was to evaluate tumour regression in a large series of choroidal melanomas, which were treated with three different eye-sparing treatment modalities. PATIENTS AND METHODS: Retrospective review of the treatment results in all eyes with malignant choroidal melanoma, which were treated in the University Eye Clinic of Mainz consecutively in the time span 1.1992 to 12.2000 with transpupillary thermotherapy (TTT, standard protocol Oosterhuis JA 1995), ruthenium brachytherapy (RB, tumor apex dose 150 Gy) or sandwich therapy (ST). One-step ST was defined as TTT followed by RB with 100 Gy tumor apex dose within 48 hours. The treatment of residual prominences with TTT s…
High-flow nasal therapy versus noninvasive ventilation in COPD patients with mild-to-moderate hypercapnic acute respiratory failure: study protocol f…
2019
Background Noninvasive ventilation (NIV) is indicated to treat respiratory acidosis due to exacerbation of chronic obstructive pulmonary disease (COPD). Recent nonrandomized studies also demonstrated some physiological effects of high-flow nasal therapy (HFNT) in COPD patients. We designed a prospective, unblinded, multicenter, randomized controlled trial to assess the noninferiority of HFNT compared to NIV with respect to the reduction of arterial partial pressure of carbon dioxide (PaCO2) in patients with hypercapnic acute respiratory failure with mild-to-moderate respiratory acidosis. Methods We will enroll adult patients with acute hypercapnic respiratory failure, as defined by arterial…
Channel Switching Protocols Hinder the Transition to IP World: The Pentagon Story
2019
In this paper, we target the strategy for telecommunications architectures during the transition to the IP-only models. The paper discusses the shifting from circuit switching to packet switching in telecommunications. Particularly, we analyze the coexistence of circuit switching and packet switching technologies in American military communications where each warfare object should have own IP address. The paper discusses the role of multifunction Soft Switches (MFSS). This Soft Switch plays the role of a media gateway between TDM channels and IP channels. As a case, we are passing through the transformation from SS7 signaling to internet protocol, ISDN-based government Defense Red Switch Ne…
Climate Change and Energy Issues in the North
2011
Highly industrialized societies are mostly responsible for the emerging anthropogenic climate change. There are different ways to measure this responsibility (e.g., whether based on causal contribution or strict responsibility, see Muller et al. 2007). However, regardless of the specific method applied to measure the impact, presently, the USA and the EU are the global leaders in green house gas emissions with countries such as China, India and Brazil following closely behind. Globally, GHG emissions are still increasing among the highly industrialized countries, particularly in the USA – a country that never ratified the Kyoto Protocol. However, the EU has managed to curb its emissions, co…
Extended pancreas donor program – the EXPAND study rationale and study protocol
2013
Background Simultaneous pancreas kidney transplantation (SPK), pancreas transplantation alone (PTA) or pancreas transplantation after kidney (PAK) are the only curative treatment options for patients with type 1 (juvenile) diabetes mellitus with or without impaired renal function. Unfortunately, transplant waiting lists for this indication are increasing because the current organ acceptability criteria are restrictive; morbidity and mortality significantly increase with time on the waitlist. Currently, only pancreas organs from donors younger than 50 years of age and with a body mass index (BMI) less than 30 are allocated for transplantation in the Eurotransplant (ET) area. To address this …
New ECCO model documents for Material Deposit and Transfer Agreements in compliance with the Nagoya Protocol
2020
The European Culture Collections Organisation presents two new model documents for Material Deposit Agreement (MDA) and Material Transfer Agreement (MTA) designed to enable microbial culture collection leaders to draft appropriate agreement documents for, respectively, deposit and supply of materials from a public collection. These tools provide guidance to collections seeking to draft an MDA and MTA, and are available in open access to be used, modified, and shared. The MDA model consists of a set of core fields typically included in a deposit form to collect relevant information to facilitate assessment of the status of the material under access and benefit sharing (ABS) legislation. It a…
Evaluation of ABC gene polymorphisms on the pharmacokinetics and pharmacodynamics of capecitabine in colorectal patients: Implications for dosing rec…
2020
Aims The aims are to develop a population pharmacokinetic model of capecitabine (CAP) and its main metabolites after the oral administration of CAP in colorectal cancer patients with different polymorphisms of the ATP-binding cassette (ABC) gene and a population pharmacokinetic/pharmacodynamic model capable of accounting for the neutropenic effects, and to optimize the dosing strategy based on the polymorphisms of the ABC gene and/or the administration regimen as a single agent or in combination. Methods Forty-eight patients diagnosed with colorectal cancer were included, with 432 plasma levels of CAP, 5'-desoxi-5-fluorouridine (5'-DFUR) and 5-fluorouracil (5-FU), and 370 neutrophil observa…
Biopiracy versus One-World Medicine-From colonial relicts to global collaborative concepts.
2017
Abstract Background Practices of biopiracy to use genetic resources and indigenous knowledge by Western companies without benefit-sharing of those, who generated the traditional knowledge, can be understood as form of neocolonialism. Hypothesis The One-World Medicine concept attempts to merge the best of traditional medicine from developing countries and conventional Western medicine for the sake of patients around the globe. Study design Based on literature searches in several databases, a concept paper has been written. Legislative initiatives of the United Nations culminated in the Nagoya protocol aim to protect traditional knowledge and regulate benefit-sharing with indigenous communiti…