Search results for " protocol"
showing 10 items of 1320 documents
The treatment of advanced gastric cancer: current strategies and future perspectives.
2008
Current questions for the treatment of advanced gastric cancer.
2013
Abstract Background Gastric cancer remains a major health problem worldwide. Treatment of advanced gastric cancer is controversial and there is no standard regimen for first- or second-line chemotherapy (CT). This review aims to give an overview of the hot topics concerning treatment, prognostic factors and new strategies in advanced gastric cancer. Material and methods Seven questions of special clinical interest have been formulated previously to the literature review. With the aim of answering each of these questions, a specific search of the relevant trials and meta-analyses published or communicated from 1990 to date was performed. Results Patients treated with CT have a survival benef…
Functional categories of TP53 mutation in colorectal cancer: results of an International Collaborative Study.
2006
Item does not contain fulltext BACKGROUND: Loss of TP53 function through gene mutation is a critical event in the development and progression of many tumour types including colorectal cancer (CRC). In vitro studies have found considerable heterogeneity amongst different TP53 mutants in terms of their transactivating abilities. The aim of this work was to evaluate whether TP53 mutations classified as functionally inactive (< or=20% of wildtype transactivation ability) had different prognostic and predictive values in CRC compared with mutations that retained significant activity. MATERIALS AND METHODS: TP53 mutations within a large, international database of CRC (n = 3583) were classified ac…
Phase I/II trial of capecitabine and oxaliplatin in combination with bevacizumab and imatinib in patients with metastatic colorectal cancer: AIO KRK …
2013
Background: Combined inhibition of platelet-derived growth factor receptor beta signalling and vascular endothelial growth factor promotes vascular normalisation in preclinical models and may lead to increased delivery of chemotherapy to tumour tissue. This phase I/II trial assessed the safety and efficacy of capecitabine plus oxaliplatin (XELOX) plus bevacizumab and imatinib in the first-line treatment of patients with metastatic colorectal cancer. Methods: Two dose levels (I/II) were defined: capecitabine 850/1000 mg m−2 twice daily on days 1–14; oxaliplatin 100/130 mg m−2 on day 1; bevacizumab 7.5 mg kg−1 on day 1; imatinib 300 mg day−1 on days 1–21 every 21 days. The primary study endpo…
Neoadjuvant chemotherapy for stage IIIA-N2 non-small cell lung cancer
2005
Neoadjuvant chemotherapy in potentially resectable stage IIIA-N2 non-small cell lung cancer (NSCLC) has become standard of treatment in the last years. Two randomised pioneer phase III trials conducted with second generation platinum combinations had demonstrated an advantage in survival of induction chemotherapy followed by surgery versus surgery alone. Subsequently, a wide number of phase II studies with third generation platinum-based doublets or triplets have increased the evidence of the activity as well as the good tolerability of this approach. Nowadays, the main topics of ongoing clinical research are to assess the role of induction chemotherapy in early stage disease, and the role …
Autonomous agent system using dispatching rules in the negotiation protocol
2002
In this paper, the most important results obtained by the simulated application of autonomous agent paradigms to a. real factory are presented. The classical rules of dispatching are compared with the autonomous agents approach. In particular, the possibility of redesigning the negotiation rules in terms of currency in order to take into account even non-time-related costs is considered. Finally, a new project on the effective application of the autonomous agent system to a test bed, modelling a simplified firm, is proposed.
VII: Diagnosestudien: Einfache Maße für Validität und Reliabilität
2003
The evaluation of a new diagnostic or imaging device has to focus both on its diagnostic validity and reliability. Cohen's kappa coefficient can be used to assess the agreement of the new device's findings with those of an established diagnostic reference, it therefore presents a surrogate measure of validity. Additional measures of validity are sensitivity and specificity, which assess the order of agreement with the reference for positive and negative reference findings, respectively. The latter, however, can only be applied for binary reference findings. If discordant findings are observed, the McNemar test can be used to detect a diagnostic shift between diagnostic novum and reference. …
A Novel Multi-hop Broadcasting Method for VANETs Based on Autonomic Computing Paradigm
2014
One of the three best papers, Selected for the Annals of Telecommunications journal; International audience; Broadcasting is widely used in Vehicular Ad hoc Networks (VANETs) but it is hard to achieve efficiently since it depends on the network density, i.e. may cause network congestion if the protocols are not well designed. This paper introduces a novel Autonomic Dissemination Method (ADM) which delivers messages in accordance with given priority and density levels. The proposed approach is based on two steps: an offline optimization process and an online adaptation to the network characteristics. The aim is to make effective use of radio resources when there are many messages to send imu…
Oral Lichen Planus: a new experimental therapeutic protocol by means of oxygen-ozone mixture injection.
2019
iCanCope With Pain: Cultural Adaptation and Usability Testing of a Self-Management App for Adolescents With Persistent Pain in Norway.
2019
Background: Persistent or chronic pain is a common health problem among adolescents. Thus, it is important that they receive evidence-based strategies for symptom management. iCanCope with Pain is a mobile phone app designed to help adolescents cope with chronic pain. The app comprises 5 evidence- and theory-based features: (I) symptom trackers for pain, sleep, mood, physical function, and energy; (II) goal setting to improve pain and function; (III) a coping toolbox of pain self-management strategies; (IV) social support; and (V) age-appropriate pain education. The iCanCope with Pain app is based on theory, identified health care needs, and current best practices for pain self-management. …