Search results for " rando"
showing 8 items of 498 documents
Random Walk and Diffusion
2014
The concept of random walk as introduced by Einstein is introduced. It is shown that a random walk on a lattice can be descrbed by a difference equation, which becomes a partial differential equation (diffusion equation) in the continuum limit. The equation is solved with the help of Fourier and Laplace transformations.
A Stochastic Algorithm Based on Fast Marching for Automatic Capacitance Extraction in Non-Manhattan Geometries
2014
WOS:000346854900026 (Nº de Acesso Web of Science) We present an algorithm for two- and three-dimensional capacitance analysis on multidielectric integrated circuits of arbitrary geometry. Our algorithm is stochastic in nature and as such fully parallelizable. It is intended to extract capacitance entries directly from a pixelized representation of the integrated circuit (IC), which can be produced from a scanning electron microscopy image. Preprocessing and monitoring of the capacitance calculation are kept to a minimum, thanks to the use of distance maps automatically generated with a fast marching technique. Numerical validation of the algorithm shows that the systematic error of the algo…
A Serendipity-Oriented Greedy Algorithm for Recommendations
2017
Most recommender systems suggest items to a user that are popular among all users and similar to items the user usually consumes. As a result, a user receives recommendations that she/he is already familiar with or would find anyway, leading to low satisfaction. To overcome this problem, a recommender system should suggest novel, relevant and unexpected, i.e. serendipitous items. In this paper, we propose a serendipity-oriented algorithm, which improves serendipity through feature diversification and helps overcome the overspecialization problem. To evaluate our algorithm and compare it with others, we employ a serendipity metric that captures each component of serendipity, unlike the most …
Effect of RNS60 in amyotrophic lateral sclerosis: a phase II multicentre, randomized, double-blind, placebo-controlled trial
2022
Background and purpose: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with limited treatment options. RNS60 is an immunomodulatory and neuroprotective investigational product that has shown efficacy in animal models of ALS and other neurodegenerative diseases. Its administration has been safe and well tolerated in ALS subjects in previous early phase trials. Methods: This was a phase II, multicentre, randomized, double-blind, placebo-controlled, parallel-group trial. Participants diagnosed with definite, probable or probable laboratory-supported ALS were assigned to receive RNS60 or placebo administered for 24 weeks intravenously (375 ml) once a week and via nebul…
Real-world experience with obeticholic acid in patients with primary biliary cholangitis
2021
Background & aims Obeticholic acid (OCA) is the second-line treatment approved for patients with primary biliary cholangitis (PBC) and an inadequate response or intolerance to ursodeoxycholic acid. We aimed to evaluate the effectiveness and safety of OCA under real-world conditions. Methods Patients were recruited into the Italian PBC Registry, a multicentre, observational cohort study that monitors patients with PBC at national level. The primary endpoint was the biochemical response according to Poise criteria; the secondary endpoint was the biochemical response according to normal range criteria, defined as normal levels of bilirubin, alkaline phosphatase (ALP), and alanine aminotransfer…
Effectiveness of a kindergarten-based intervention to increase vegetable intake and reduce food neophobia amongst 1-year-old children: a cluster rand…
2021
Background: Children’s first years of life are crucial to their future health. Studies show that a varied diet with a high intake of vegetables is positive in several domains of health. The present low vegetable intake amongst children is, therefore, a concern. Food neophobia is a common barrier to vegetable intake in children. As most Norwegian children attend kindergarten from an early age, kindergartens could contribute to the prevention of food neophobia and the promotion of vegetable intake. Objective: The aim of this study was to assess the effect of a cluster randomised trial amongst 1-year-old children in kindergarten to reduce food neophobia and promote healthy eating. Methods: Kin…
Univariate and multivariate properties of wind velocity time series
2009
We analyze the time series of hourly average wind speeds measured at 29 different stations located in Sicily, a region with a complex morphology. The investigation, performed from the univariate as well as the multivariate point of view, evidences that the statistical properties of wind at the single sites have features that are not reproduced by standard models and, thus, require specific modeling. Moreover, the synchronous evolution of wind velocity presents a cluster structure, obtained with different algorithms, that persists in the standard deviation too.