Search results for " rap"
showing 10 items of 561 documents
Toward more realistic viscosity measurements of tyre rubber–bitumen blends
2014
AbstractThe measurement of rheological properties of the tyre rubber bitumen blends is often challenging due to presence of suspended tyre rubber’s crumbs. Furthermore, the phase separation during the course of measurements makes the viscosity of these non-homogeneous blends difficult to ascertain. In this study, a new dual helical impeller was designed and manufactured to be used with a rotational viscometer in order to have a real-time control of the viscosity while performing a laboratory mixing of the blends. Layer based manufacturing techniques showed to be a convenient method to produce complex shaped impeller prototypes before manufacturing the more expensive stainless steel assembly…
Declinazioni del rapporto tra le arti e l'architettura nella prima metà del Novecento: i Palazzi di Giustizia in Sicilia
2021
La tesi affronta la tematica del rapporto tra le arti e l’architettura, ricorrente nei dibattiti culturali sin dalla primigenia antinomia téchne/ars ma di particolare importanza nella prima metà del Novecento. Dapprima la questione viene inquadrata a livello generale, tramite l’analisi di tre episodi peculiari dei primi decenni del ventesimo secolo, ossia: la quinta edizione della Triennale di Milano del 1933, consacrata alla pittura murale; il sesto Convegno Volta del 1936, dedicato al tema “Rapporti dell’architettura con le arti figurative”; la promulgazione della Legge del 2%, che prevedeva la destinazione di almeno la suddetta percentuale, rispetto al totale della spesa preventivata, pe…
Mboat7 down-regulation by hyper-insulinemia induces fat accumulation in hepatocytes.
2020
Background: Naturally occurring variation in Membrane-bound O-acyltransferase domain-containing 7 (MBOAT7), encoding for an enzyme involved in phosphatidylinositol acyl-chain remodelling, has been associated with fatty liver and hepatic disorders. Here, we examined the relationship between hepatic Mboat7 down-regulation and fat accumulation. Methods: Hepatic MBOAT7 expression was surveyed in 119 obese individuals and in experimental models. MBOAT7 was acutely silenced by antisense oligonucleotides in C57Bl/6 mice, and by CRISPR/Cas9 in HepG2 hepatocytes. Findings: In obese individuals, hepatic MBOAT7 mRNA decreased from normal liver to steatohepatitis, independently of diabetes, inflammatio…
Mount Etna: fra viaggio turistico, turismo scenico e viaggio di esplorazione
2009
Pathogenesis and molecular mechanisms of anderson–fabry disease and possible new molecular addressed therapeutic strategies
2021
Anderson–Fabry disease (AFD) is a rare disease with an incidenceof approximately 1:117,000 male births. Lysosomal accumulation of globotriaosylceramide (Gb3) is the element characterizing Fabry disease due to a hereditary deficiency α-galactosidase A (GLA) enzyme. The accumulation of Gb3 causes lysosomal dysfunction that compromises cell signaling pathways. Deposition of sphingolipids occurs in the autonomic nervous system, dorsal root ganglia, kidney epithelial cells, vascular system cells, and myocardial cells, resulting in organ failure. This manuscript will review the molecular pathogenetic pathways involved in Anderson–Fabry disease and in its organ damage. Some studies reported that i…
Serotonergic versus non-serotonergic dorsal raphe projection neurons differential participation in reward circuitry
ROLE OF DORSAL RAPHE NUCLEUS AND VENTRAL TEGMENTAL AREA ON REWARD AND FEEDING BEHAVIORS IN MICE
Promoter architecture and transcriptional regulation of Abf1-dependent ribosomal protein genes inSaccharomyces cerevisiae
2016
In Saccharomyces cerevisiae, ribosomal protein gene (RPG) promoters display binding sites for either Rap1 or Abf1 transcription factors. Unlike Rap1-associated promoters, the small cohort of Abf1-dependent RPGs (Abf1-RPGs) has not been extensively investigated. We show that RPL3, RPL4B, RPP1A, RPS22B and RPS28A/B share a common promoter architecture, with an Abf1 site upstream of a conserved element matching the sequence recognized by Fhl1, a transcription factor which together with Ifh1 orchestrates Rap1-associated RPG regulation. Abf1 and Fhl1 promoter association was confirmed by ChIP and/or gel retardation assays. Mutational analysis revealed a more severe requirement of Abf1 than Fhl1 …
Il Caffè Arabo alla IV Esposizione Nazionale di Palermo: dai disegni di Ernesto Basile alla ricostruzione virtuale
2016
A partire dalla rilettura di disegni originali di progetto e riproduzioni grafiche d’epoca, il contributo indaga il caffè arabo progettato da Ernesto Basile per la IV Esposizione Nazionale di Palermo. Il presente studio rientra nel filone delle ricostruzioni virtuali di architetture non più esistenti o solo disegnate e si configura quale tassello mancante di un lavoro più ampio e già edito riguardante la maggior parte del complesso espositivo. La ricostruzione virtuale si connota quale strumento di indagine e visualizzazione di un’architettura effimera, in una parte di città perduta. This text studies the project for the Caffé Arabo designed by Ernesto Basile for the IV Esposizione Nazional…