Search results for " reaction"
showing 10 items of 4906 documents
Open-source QCD analysis of nuclear parton distribution functions at NLO and NNLO
2019
We present new sets of nuclear parton distribution functions (nPDFs) at next-to-leading order (NLO) and next-to-next-to-leading order (NNLO). Our analyses are based on deeply inelastic scattering data with charged-lepton and neutrino beams on nuclear targets. In addition, a set of proton baseline PDFs is fitted within the same framework with the same theoretical assumptions. The results of this global QCD analysis are compared to existing nPDF sets and to the fitted cross sections. Also, the uncertainties resulting from the limited constraining power of the included experimental data are presented. The published work is based on an open-source tool, xFitter, which has been modified to be ap…
Mukaiyama-Michael reactions with α-substituted acroleins - a useful tool for the synthesis of the pectenotoxins and other natural product targets
2013
Synthesis and Molecular Modeling Studies of Derivatives of a Highly Potent Peptidomimetic Vinyl Ester as Falcipain-2 Inhibitors
2012
Herein we report the synthesis of a set of constrained peptidomimetics endowed with an electrophilic vinyl ester warhead and structurally related to a previously identified lead compound, a potent and irreversible inhibitor of falcipain-2 (FP-2). FP-2 is the main hemoglobinase of the malaria parasite P. falciparum. The new compounds were evaluated for their inhibition against FP-2, and the results were rationalized on the basis of docking experiments. These studies underscore the pivotal role of both the ester function at the P1' site and the trifluoromethyl group of the P3 side chain in determining the correct orientation of the Michael acceptor warhead in the catalytic site, and as a cons…
THE ROLE OF THE CLINICAL PHARMACIST IN THE MANAGEMENT OF ANTIRETROVIRAL THERAPY
2020
Over the last few years, the Hospital Pharmacy has developed in an excellent way in Europe, proposing in many countries the clinical pharmacist as a new professional figure, and adapting its responsibilities to national health systems. The purpose of this study is to evaluate and promote the prescriptive appropriateness through the close collaboration between the pharmacist and the medical team. The aspect of the dispensation of antiretroviral therapy was deepened by providing useful information to the patient on the possible undesired effects and interactions due to the polypharmacy, on the correct way of storing the drugs, and on the importance of the regularity of the polypharmacy intake…
Conformational-Dependent Photodissociation of Glycolic Acid in an Argon Matrix
2023
Ultraviolet-induced photodissociation and photo-isomerization of the three most stable conformers (SSC, GAC, and AAT) of glycolic acid are investigated in a low-temperature solid argon matrix using FTIR spectroscopy and employing laser radiation with wavelengths of 212 nm, 226 nm, and 230 nm. The present work broadens the wavelength range of photochemical studies of glycolic acid, thus extending the understanding of the overall photochemistry of the compound. The proposed kinetic model for the photodissociation of glycolic acid proceeds from the lowest energy conformer (SSC). The model suggests that ultraviolet light induces isomerization only between the SSC and GAC conformers and between …
Majorana parameters of the interacting boson model of nuclear structure and their implication for 0νββ decay
2021
Nucleon dissociation and incoherent J/ψ photoproduction on nuclei in ion ultraperipheral collisions at the CERN Large Hadron Collider
2019
Using the general notion of cross section fluctuations in hadron-nucleus scattering at high energies, we derive an expression for the cross section of incoherent J / ψ photoproduction on heavy nuclei d σ γ A → J / ψ Y / d t , which includes both elastic d σ γ p → J / ψ p / d t and proton-dissociation d σ γ p → J / ψ Y / d t photoproduction on target nucleons. We find that, with good accuracy, d σ γ A → J / ψ Y / d t can be expressed as a product of the sum of the d σ γ p → J / ψ p / d t and d σ γ p → J / ψ Y / d t cross sections, which have been measured at HERA, and the common nuclear shadowing factor, which is calculated using the leading twist nuclear shadowing model. Our prediction for …
Facile and efficient chemical functionalization of aliphatic polyesters by cross metathesis
2016
International audience; An effective preparation of new tailor-made macromolecular materials via a combination of two (atom-efficient) catalytic transformations is reported. First, new aliphatic polyesters with alternated composition have been prepared using a salen aluminum catalyst system. Next, the pendant vinyl moieties in those copolymers have been selectively transformed into various functional groups by metathesis in the presence of homogeneous Grubbs catalysts. The latter metathesis reaction has been optimized in terms of catalytic activity and selectivity, to define the conditions for an effective and safe procedure that does not affect the macromolecular architecture. All polymer …
Direct asymmetric aldol reaction using polystyrene-supported proline amide
2008
Determinación de Streptococcus Mutans y Streptococcus Sobrinus, mediante pcr cuantitativa a tiempo real, y su relación con la caries dental en escola…
2013
La caries dental presenta una etiología multifactorial, los factores ambientales, los hábitos de alimentación, higiene bucal y la susceptibilidad genética individual, juegan un papel importante en el desarrollo de esta enfermedad (1). Los Streptococcus mutans y Streptococcus sobrinus están fuertemente implicados en la aparición de la caries dental en humanos. Numerosos estudios han demostrado que la asociación de S. mutans y S. sobrinus conlleva niveles más altos de caries (2-4) y varios estudios han encontrado que la prevalencia deS. sobrinus está fuertemente asociada con mayor actividad de caries que la delS. mutans (5-6). Se considera que la determinación de estas dos especies en la infa…