Search results for " regulation."

Transgenic overexpression of corticotropin releasing hormone provides partial protection against neurodegeneration in an in vivo model of acute excit…

2008

Abstract Corticotropin releasing hormone (CRH) is the central modulator of the mammalian hypothalamic–pituitary–adrenal (HPA) axis. In addition, CRH affects other processes in the brain including learning, memory, and synaptic plasticity. Moreover, CRH has been shown to play a role in nerve cell survival under apoptotic conditions and to serve as an endogenous neuroprotectant in vitro . Employing mice overexpressing murine CRH in the CNS, we observed a differential response of CRH-overexpressing mice (CRH-COE hom -Nes) to acute excitotoxic stress induced by kainate compared with controls (CRH-COE con -Nes). Interestingly, CRH-overexpression reduced the duration of epileptic seizures and pre…

Melatonin stimulates the nonamyloidogenic processing ofβAPP through the positive transcriptional regulation of ADAM10 and ADAM17

2014

Melatonin controls many physiological functions including regulation of the circadian rhythm and clearance of free radicals and neuroprotection. Importantly, melatonin levels strongly decrease as we age and patients with Alzheimer's disease (AD) display lower melatonin than age-matched controls. Several studies have reported that melatonin can reduce aggregation and toxicity of amyloid-β peptides that are produced from the β-amyloid precursor protein (βAPP). However, whether melatonin can directly regulate the βAPP-cleaving proteases ('secretases') has not been investigated so far. In this study, we establish that melatonin stimulates the α-secretase cleavage of βAPP in cultured neuronal an…

Elevated cortisol modulates hsp70 and hsp90 gene expression and protein in sea bass head kidney and isolated leukocytes

2012

In fish, interactions between Hsps and cortisol are involved in stress modulated physiological processes including innate immune responses. Cortisol exerts a role in the regulation of Hsps synthesis. Fish head kidney is a lymphomieloid and endocrine organ releasing cortisol, and it is the central organ for immune-endocrine interactions. In sea bass, cortisol intraperitoneal injection and in vitro treatment of head kidney cells show that inducible Hsp70 and Hsp90 are modulated by this hormone. However, an inverse relationship between mRNA expression (real-time PCR) and Hsp70 and Hsp90 protein levels (densitometric band analysis) was found. Time-course assays indicate a cortisol-mediated regu…

Multilevel energy regulation : a study of NVE’s connections and autonomy in a European context

2016

Masteroppgave offentlig politikk og ledelse- Universitetet i Agder, 2016 An evolving European executive order is changing the circumstances for national steering and administrative capacities. Increasingly compound and interconnected administrative structures that span across levels of governance provide an environment where domestic agencies might be serving multiple organizations or centres of authority simultaneously. Thus potentially challenging national control and accountability. This thesis has set out to map NVE’s potential participation in such multilevel administrative structures for energy regulation in Europe. By examining NVE’s connection and contact with its ministry departmen…

The Functioning of Local Government Authorities in Poland in the Conditions of the Epidemic in Relation to the SARS-CoV-2 Coronavirus – General Consi…

2023

Wartykule przedstawiono wybrane aspekty funkcjonowania samorządu terytorialnego wPol-sce wwarunkach epidemii wzwiązku zkoronawirusem SARS-CoV-2. Więcej miejsca poświęcono aspektom ustrojowym, natomiast aspekty materialnoprawne iproceduralne zostały zasygnalizowane, ponieważ ich rozwinięcie wykracza poza ramy niniejszego opracowania. Celem jest odpowiedź na pytanie, wjakim stopniu obecnie obowiązujące przepisy, zuwzględnieniem nowych regulacji prawnych, umożliwiają realizację zadań publicznych oraz wjaki sposób nowe regulacje modyfiku-ją dotychczasowe zadania. Wartykule sformułowano tezę, że dotychczasowe przepisy mogą być stosowane wwarunkach epidemicznych, ale po dokonaniu modyfikacji koni…

Estrogen regulates muscle bioenergetic signaling

2018

Functional muscle architecture in aging

2014

Empirical Study on the Relationship between the Cross-Correlation among Stocks and the Stocks' Volatility Clustering

2013

In this paper we discuss univariate and multivariate statistical properties of volatility with the aim of understanding how these two aspects are interrelated. Specifically, we focus on the relationship between the cross-correlation among stock's volatilities and the volatility clustering. Volatility clustering is related to the memory property of the volatility time-series and therefore to its predictability. Our results show that there exists a relationship between the level of predictability of any volatility time-series and the amount of its inter-dependence with other assets. In all considered cases, the more the asset is linked to other assets, the more its volatility keeps memory of …

F-type lectin from the sea bass (Dicentrarchus labrax): purification, cDNA cloning, tissue expression and localization, and opsonic activity.

2009

Recently described biochemical and structural aspects of fucose-binding lectins from the European eel (Anguilla anguilla) and striped bass (Morone saxatilis) led to the identification of a novel lectin family ("F-type" lectins) characterized by a unique sequence motif and a characteristic structural fold. The F-type fold is shared not only with other members of this lectin family, but also with apparently unrelated proteins ranging from prokaryotes to vertebrates. Here we describe the purification, biochemical and molecular properties, and the opsonic activity of an F-type lectin (DlFBL) isolated from sea bass (Dicentrarchus labrax) serum. DlFBL exhibits two tandemly arranged carbohydrate-r…

Role of dioxygenase α-DOX2 and SA in basal response and in hexanoic acid-induced resistance of tomato (Solanum lycopersicum) plants against Botrytis …

2015

Resistance of tomato (Solanum Lycopersicum) to the fungal pathogen Botrytis cinerea requires complex interplay between hormonal signalling. In this study, we explored the involvement of new oxylipins in the tomato basal and induced response to this necrotroph through the functional analysis of the tomato α-dioxygenase2 (α-DOX2)-deficient mutant divaricata. We also investigated the role of SA in the defence response against this necrotrophic fungus using SA-deficient tomato nahG plants. The plants lacking dioxigenase α-DOX2, which catalyses oxylipins production from fatty acids, were more susceptible to Botrytis, and hexanoic acid-induced resistance (Hx-IR) was impaired; hence α-DOX2 is requ…