Search results for " release"

Sensitivity and negative predictive value of treadmill exercise stress testing for the diagnosis of catecholaminergic polymorphic ventricular tachyca…

2015

Nortriptyline for smoking cessation: Release and human skin diffusion from patches

2009

Abstract The objective of this work was to develop a simple and inexpensive transdermal formulation containing Nortriptyline Hydrochloride (NTH) for smoking cessation support therapy. Hydroxypropyl-methyl-cellulose was chosen as polymer and a mixture of transdermal enhancers (selected from previous research) was incorporated. The formulations were characterised in terms of appearance, thickness, uniformity of NTH content, release and skin permeation. Release studies demonstrated controlled release for four formulations. Diffusion studies were performed through human heat separated epidermis (HHSE) using Franz Diffusion Cells (FDC). Patches provided different fluxes varying from 20.39 ± 7.09…

New Biodegradable Hydrogels Based on Inulin and α,β-Polyaspartylhydrazide Designed for Colonic Drug Delivery: In Vitro Release of Glutathione and Oxy…

2010

Succinic derivatives of inulin (INU-SA) with two different degrees of derivatization (20% and 30%, mol/mol) were cross-linked with α,β-polyaspartylhydrazide (PAHy) to obtain INUPAHy hydrogels. Cross-linking was performed using N-ethyl-N-(3-dimethylaminopropyl)-carbodiimide hydrochloride (EDC) and N-hydroxysulfosuccinimide (NHSS) as coupling agents and by varying the reaction time (4 h, 8 h and 24 h). All samples prepared were characterized by FT-IR analysis and swelling measurements in different media. In vitro assays, performed in the presence of inulinase, demonstrated the degradability of the prepared hydrogels. Cell compatibility was evaluated using Caco-2 cells through both direct and …

Evaluation of toughness by finite fracture mechanics from crack onset strain of brittle coatings on polymers

2008

Crack onset strain measurements of a confined layer in tension provide the means for layer toughness estimation. The procedure can be simplified if steady-state conditions prevail starting from the commencement of crack propagation, an assumption frequently employed in energy release rate evaluation. It is demonstrated, by numerical analysis of experimental data, that an estimate of the defect size in the film is needed in order to reliably evaluate its fracture toughness from the crack onset strain. Only if microcracks of sufficient size are present in the brittle layer, the steady-state energy release rate at the crack onset strain can be identified with layer toughness. Otherwise, the to…

Coronaviral Ion Channels as Target for Chinese Herbal Medicine

2012

Successful Treatment of Suspected Donor-derived Human Herpesvirus-8 Infection in a Liver Transplant Patient With Coronavirus Disease-19

2021

The publication of news about the results of R+D+I. How do Spanish researchers perceive it?

2018

El objetivo de este estudio es conocer cúal es la percepción que tienen los investigadores de las universidades españolas sobre el impacto que generan, sobre sus carreras profesionales, las noticias científicas que se publicancon los resultados de sus actividades de Investigación, Desarrollo e Innovación (I+D+i). Para ello, se han seleccionado los datos obtenidos por una encuesta online realizada en el año 2016 de 602 investigadores y profesionales de la comunicación científica de 20 universidades de España, teniendo único requisito que alguna de sus publicaciones hubiera sido objeto de —al menos— una nota de prensa difundida por su universidad en los últimos cinco años. Para el…

INDUCTION OF VEGF RELEASE BY TRANSCUTANEOUS FREQUENCY MODULATED NEURAL STIMULATION IN DIABETIC POLYNEUROPATHY

2007

Vascular Endothelial Growth Factor-Releasing Microspheres Based on Poly(ε-Caprolactone-PEG-ε-Caprolactone)-b-Poly(L-Lactide) Multiblock Copolymers In…

2020

Pancreatic islet transplantation is a promising advanced therapy that has been used to treat patients suffering from diabetes type 1. Traditionally, pancreatic islets are infused via the portal vein, which is subsequently intended to engraft in the liver. Severe immunosuppressive treatments are necessary, however, to prevent rejection of the transplanted islets. Novel approaches therefore have focused on encapsulation of the islets in biomaterial implants which can protect the islets and offer an organ-like environment. Vascularization of the device’s surface is a prerequisite for the survival and proper func- tioning of transplanted pancreatic islets. We are pursuing a prevascularization s…

Answering Schrödinger's "What Is Life?"

2020

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