Search results for " release"

BEM analysis of a piezoelectric structural health monitoring system for delamination detection

2013

In the present work a piezoelectric based structural health monitoring (SHM) system is analyzed with the aim of assessing the ability of the piezoelectric patch to detect both edge and embedded delaminations proper of flange-skin composite laminated structures. he boundary element model is developed for piezoelectric solids and is implemented by taking advantage of the multidomain technique to model laminated and cracked configurations. A non-linear spring model interface is then implemented in conjunction with an iterative procedure allowing for the simulation of the finite stiffness of the bonding layers as well as of the non-penetration condition of the delamination surfaces. he dynamic …

In Vitro Evaluation of Poly(lactide-co-glycolide) In Situ Forming Gels for Bedaquiline Fumarate Salt and Pharmacokinetics Following Subcutaneous Inje…

2021

This study evaluated in vitro and in vivo drug release of bedaquiline from in situ forming gels (ISGs) containing 200 mg eq./g bedaquiline fumarate salt prepared with four different grades of poly(d,l-lactide) (PDLLA) or poly(d,l-lactide-co-glycolide) (PLGA) with a lactide/glycolide ratio of 50/50 or 75/25 and acid (A) or ester (E) end-capping in N-methyl-2-pyrrolidone at a polymer/solvent ratio of 20/80% (w/w). Mean in vitro drug release in 0.05 M phosphate buffer pH 7.4 with 1% (w/v) sodium lauryl sulphate was 37.3, 47.1, 53.3, and 62.3% within 28 days for ISGs containing PLGA5050A, PDLLA, PLGA7525A, and PLGA7525E, respectively. The data suggested that drug release was primarily controlle…

Scientific writing for impact factor journals

2013

EASARCICAPLivre dispo. dans :hal-00832739, version 1; Publish or Perish. This old adage illustrates the importance of scientific communication; essential to research, it also represents a strategic sector for each country’s competitiveness. An often-neglected topic, scientific communication is of vital importance, with new information technologies accelerating and profoundly changing how knowledge is disseminated. The necessity of optimally disseminating experts’ findings has also become crucial to researchers, institutes and universities alike, which has prompted the recent advent of Impact Factors for the evaluation and financing of research, the goal being for scientific knowledge to be …

SMART NANOSPONGE-BASED SYSTEMS FOR ADVANCED APPLICATIONS

2023

Interactions between saliva, mucosae and flavor compounds

2018

International audience

Chewing simulation: a way to understand the relationships between mastication, food breakdown and flavour release

2010

International audience; Understanding in-mouth mechanisms is necessary to understand flavour release and perception phenomena. To overcome the limitations of in-vivo flavour release measurements, we developed a chewing simulator that faithfully reproduced many mouth functions. Using brittle foods, we showed that in-vitro food breakdown was very comparable to that obtained in-vivo. We also studied on model cheeses in-vitro flavour release by connecting on-line the chewing simulator to APCI-MS. Preliminary results are discussed.

Micromaterials lipid-based for topic release of fluticasone propionate for the COPD treatment

2016

Experimental Evolution Reveals a Genetic Basis for Membrane-Associated Virus Release

2021

Many animal viruses replicate and are released from cells in close association to membranes. However, whether this is a passive process or is controlled by the virus remains poorly understood. Importantly, the genetic basis and evolvability of membrane-associated viral shedding have not been investigated. To address this, we performed a directed evolution experiment using coxsackievirus B3, a model enterovirus, in which we repeatedly selected the free-virion or the fast-sedimenting membrane-associated viral subpopulations. The virus responded to this selection regime by reproducibly fixing a series of mutations that altered the extent of membrane-associated viral shedding, as revealed by fu…

Dual Enzyme-Triggered Controlled Release on Capped Nanometric Silica Mesoporous Supports

2012

The development of nanoscopic hybrid materials equipped with “molecular gates” showing the ability of releasing target entrapped guests upon the application of an external trigger has attracted great attention and has been extensively explored during recent years.1 These nanodevices are composed of two subunits, namely, a suitable support and certain capping entities grafted on the surface of the scaffolding.2 The support is used as a suitable reservoir in which certain chemicals can be stored whereas the molecules grafted in the outer surface act as a “gate” and can control the release of the entrapped molecules at will. Both components are carefully selected and arranged in order to achie…

IgA-Dominant Infection-Associated Glomerulonephritis Following SARS-CoV-2 Infection

2021

The renal involvement of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been reported. The etiology of kidney injury appears to be tubular, mainly due to the expression of angiotensin-converting enzyme 2, the key joint receptor for SARS-CoV-2; however, cases with glomerular implication have also been documented. The multifactorial origin of this renal involvement could include virus-mediated injury, cytokine storm, angiotensin II pathway activation, complement dysregulation, hyper-coagulation, and microangiopathy. We present the renal histological findings from a patient who developed acute kidney injury and de novo nephrotic syndrome, highly suggestive of acute IgA-domina…