Search results for " relevance"

Women’s empowerment and child mortality: the case of Bangladesh

2018

Putting molecules in their place.

2014

Each class of microscope is limited to imaging specific aspects of cell structure and/or molecular organization. However, imaging the specimen by complementary microscopes and correlating the data can overcome this limitation. Whilst not a new approach, the field of correlative imaging is currently benefitting from the emergence of new microscope techniques. Here we describe the correlation of cryogenic fluorescence tomography (CFT) with soft X‐ray tomography (SXT). This amalgamation of techniques integrates 3D molecular localization data (CFT) with a high‐resolution, 3D cell reconstruction of the cell (SXT). Cells are imaged in both modalities in a near‐native, cryopreserved state. Here we…

Human stem cells from single blastomeres reveal pathways of embryonic or trophoblast fate specification.

2015

Mechanisms of initial cell fate decisions differ among species. To gain insights into lineage allocation in humans, we derived ten human embryonic stem cell lines (designated UCSFB1-10) from single blastomeres of four 8-cell embryos and one 12-cell embryo from a single couple. Compared with numerous conventional lines from blastocysts, they had unique gene expression and DNA methylation patterns that were, in part, indicative of trophoblast competence. At a transcriptional level, UCSFB lines from different embryos were often more closely related than those from the same embryo. As predicted by the transcriptomic data, immunolocalization of EOMES, T brachyury, GDF15 and active β-catenin reve…

Campsite choice and the camping tourism experience: Investigating decisive campsite attributes using relevance-determinance analysis

2017

Abstract Camping tourism represents a growing part of the overall tourism industry. Despite this fact, this form of tourism has so far been rather neglected by tourism and hospitality research. Using a case study of a major campsite operator in the coastal part of Croatia, this study thus aims to contribute to the understanding of this specific tourist segment. In particular, a relevance-determinance analysis is conducted to reveal most decisive attributes for campsite choice, on the one hand, and for the actual campsite experience, on the other hand. Overall, the results provide valuable insight to practitioners, especially for the purposes of campsite marketing and experience management.

Algunas reflexiones acerca de la stjue de 9 de julio de 2020 sobre los pactos novatorios en materia de cláusulas suelo

2021

The Sentence of the Court of Justice of the European Union of July 9, 2020 comes to answer the five questions that, in its preliminary question, the Court of First Instance and Instruction No. 3 of Teruel asks about the validity of the new agreements in the context of the floor clauses, establishing jurisprudential doctrine on this matter about which our Supreme Court had previously ruled in its Judgments of October 16, 2017, in the sense of considering the agreed floor clause null as a consequence of the novation agreement and, subsequently, those of April 11, 2018 and September 13, 2018 in the opposite direction, declaring that the novation agreement was valid. It is a long-awaited and in…

Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages.

2013

Formation of cilia, microtubule-based structures that function in propulsion and sensation, requires Kif3a, a subunit of Kinesin II essential for intraflagellar transport (IFT). We have found that, Kif3a is also required to organize centrioles. In the absence of Kif3a, the subdistal appendages of centrioles are disorganized and lack p150(Glued) and Ninein. Consequently, microtubule anchoring, centriole cohesion and basal foot formation are abrogated by loss of Kif3a. Kif3a localizes to the mother centriole and interacts with the Dynactin subunit p150(Glued) . Depletion of p150(Glued) phenocopies the effects of loss of Kif3a, indicating that Kif3a recruitment of p150(Glued) is critical for s…

Ethics in designing intelligent systems

2019

The idea of Hume’s guillotine contains the argument that one cannot derive values from facts. As intelligent systems operate with facts, Hume’s famous dilemma seems to contradict the very idea of being able to create ethical intelligent systems. In a closer look, ethics is a system of rules guiding actions. Actions always have factual or cognitive aspects, as well as evaluative or emotional aspects. Therefore, Hume’s juxtaposition of facts and norms is not well-founded. Instead of separating the facts and norms it should rather ask what kinds of facts are associated to what kinds of norms. Consequently, Hume’s guillotine sets no limits in processing ethical information, as one can combine f…

Bayesian Metanetwork for Context-Sensitive Feature Relevance

2006

Bayesian Networks are proven to be a comprehensive model to describe causal relationships among domain attributes with probabilistic measure of appropriate conditional dependency. However, depending on task and context, many attributes of the model might not be relevant. If a network has been learned across multiple contexts then all uncovered conditional dependencies are averaged over all contexts and cannot guarantee high predictive accuracy when applied to a concrete case. We are considering a context as a set of contextual attributes, which are not directly effect probability distribution of the target attributes, but they effect on a “relevance” of the predictive attributes towards tar…

Storytelling and story testing in domestication

2014

The domestication of plants and animals marks one of the most significant transitions in human, and indeed global, history. Traditionally, study of the domestication process was the exclusive domain of archaeologists and agricultural scientists; today it is an increasingly multidisciplinary enterprise that has come to involve the skills of evolutionary biologists and geneticists. Although the application of new information sources and methodologies has dramatically transformed our ability to study and understand domestication, it has also generated increasingly large and complex datasets, the interpretation of which is not straightforward. In particular, challenges of equifinality, evolutio…

Maternal body mass index, gestational weight gain, and the risk of overweight and obesity across childhood: An individual participant data meta-analy…

2019

Background Maternal obesity and excessive gestational weight gain may have persistent effects on offspring fat development. However, it remains unclear whether these effects differ by severity of obesity, and whether these effects are restricted to the extremes of maternal body mass index (BMI) and gestational weight gain. We aimed to assess the separate and combined associations of maternal BMI and gestational weight gain with the risk of overweight/obesity throughout childhood, and their population impact. Methods and findings We conducted an individual participant data meta-analysis of data from 162,129 mothers and their children from 37 pregnancy and birth cohort studies from Europe, No…