Search results for " renewal."
showing 10 items of 66 documents
Rigenerazione di aree produttive dismesse nel territorio della Val Chisone in Piemonte. L’ex setificio Gütermann di Perosa Argentina
2017
Il paper presenta i risultati parziali di un’attività di ricerca che l’autrice sta svolgendo in Piemonte nell’ambito del Bando Talenti della Società Civile promosso dalla Fondazione Giovanni Goria e dalla Fondazione CRT, cofinanziato dall’associazione spagnola INCUNA (Industria, Cultura, Naturaleza) di Gijón. La ricerca riguarda le tematiche della rigenerazione partecipata delle aree produttive dismesse come risorsa per lo sviluppo territoriale. L’articolo si focalizza sul territorio della Val Chisone, situato nella provincia torinese e a stretto contatto con la realtà transfrontaliera. La ricerca pone l’attenzione sull’analisi delle peculiarità di questa valle che grazie alla sua posizione…
Rigenerazione urbana e pratiche urbane microspaziali
2017
Nello scenario post-crisi attuale, che ha visto la sensibile riduzione delle risorse pubbliche per i progetti di rigenerazione urbana, in molte realtà urbane italiane e non solo, stiamo assistendo alla crescita di una serie di pratiche urbane micro-spaziali che stanno ridisegnando gli spazi urbani. Si tratta di esperienze che diversi studiosi hanno definito come "insurgent", "do-it-yourself" (DIY), "guerrilla", "everyday", "participatory" e/o "grassroots" urbanism (Haydn and Temel, 2006; Borasi and Zardini, 2008; Chase et al., 2008; Burnham, 2010; Hou, 2010; Zeiger, 2011a) e che si caratterizzano per una capacità proattiva che sfida gli approcci tradizionali delle politiche urbane e le loro…
Identifying opportunities for AI applications in healthcare — Renewing the national healthcare and social services
2018
A vast variety of artificial intelligence techniques have been deployed to specific healthcare problems during the last thirty years with varying levels of success while there is a shortage of systematic matching of AI capabilities with the breadth of application opportunities. In this paper, we describe the process of identifying opportunities for deploying artificial intelligence to healthcare and social services on regional and national levels in Finland. The project involved a large number of stakeholders from a variety of backgrounds ranging from governmental agencies to entrepreneurs. The process described includes idea generation of an application or solution and its elaboration in w…
Uleczyć rany: przez nawrócenie do pełnej wspólnoty. W obliczu 500-lecia Reformacji
2017
Obchody upamiętniające 500-lecie Reformacji w wielu miejscach na świecie zostały uroczyście rozpoczęte dnia 31. października 2016 r. Jest to dzień w którym Marcin Luter upublicznił swoje tezy, w oparciu o które zamierzał rozpocząć wielką debatę na temat istotnych kierunków reformy Kościoła. W szwedzkim Lund, w uroczystej inauguracji upamiętnienia tego wydarzenia wziął udział papież Franciszek wraz z b-pem Munibem Younanem, przewodniczącym Światowej Federacji Luterańskiej oraz przedstawiciele różnych Kościołów i środowisk chrześcijańskich. Wydarzenie to zainaugurowało wielką wspólną modlitwę o jedność. Stało się też początkiem nowego etapu na drodze oceny Reformacji i osoby Marcina Lutra w o…
Astrocytic Calcium Waves Signal Brain Injury to Neural Stem and Progenitor Cells
2017
Summary Brain injuries, such as stroke or trauma, induce neural stem cells in the subventricular zone (SVZ) to a neurogenic response. Very little is known about the molecular cues that signal tissue damage, even over large distances, to the SVZ. Based on our analysis of gene expression patterns in the SVZ, 48 hr after an ischemic lesion caused by middle cerebral artery occlusion, we hypothesized that the presence of an injury might be transmitted by an astrocytic traveling calcium wave rather than by diffusible factors or hypoxia. Using a newly established in vitro system we show that calcium waves induced in an astrocytic monolayer spread to neural stem and progenitor cells and increase th…
Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages
2017
The quantity and activation state of adipose tissue macrophages (ATMs) impact the development of obesity-induced metabolic diseases. Appetite-controlling hormones play key roles in obesity; however, our understanding of their effects on ATMs is limited. Here, we have shown that human and mouse ATMs express NPFFR2, a receptor for the appetite-reducing neuropeptide FF (NPFF), and that NPFFR2 expression is upregulated by IL-4, an M2-polarizing cytokine. Plasma levels of NPFF decreased in obese patients and high-fat diet-fed mice and increased following caloric restriction. NPFF promoted M2 activation and increased the proliferation of murine and human ATMs. Both M2 activation and increased ATM…
Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3
2019
International audience; Self-renewal and differentiation of pluripotent murine embryonic stem cells (ESCs) is regulated by extrinsic signaling pathways. It is less clear whether cellular metabolism instructs developmental progression. In an unbiased genome-wide CRISPR/Cas9 screen, we identified components of a conserved amino-acid-sensing pathway as critical drivers of ESC differentiation. Functional analysis revealed that lysosome activity, the Ragulator protein complex, and the tumor-suppressor protein Folliculin enable the Rag GTPases C and D to bind and seclude the bHLH transcription factor Tfe3 in the cytoplasm. In contrast, ectopic nuclear Tfe3 represses specific developmental and met…
ℓ1-Penalized Methods in High-Dimensional Gaussian Markov Random Fields
2016
In the last 20 years, we have witnessed the dramatic development of new data acquisition technologies allowing to collect massive amount of data with relatively low cost. is new feature leads Donoho to define the twenty-first century as the century of data. A major characteristic of this modern data set is that the number of measured variables is larger than the sample size; the word high-dimensional data analysis is referred to the statistical methods developed to make inference with this new kind of data. This chapter is devoted to the study of some of the most recent ℓ1-penalized methods proposed in the literature to make sparse inference in a Gaussian Markov random field (GMRF) defined …
ON HIGH-SKILL AND LOW-SKILL EQUILIBRIA: A MARKOV CHAIN APPROACH
2006
In this paper we propose to study the dynamics of human capital accumulation by means of a Markov chain. We identify the conditions for the emergence of ergodic and nonergodic dynamics, and relate them to various characteristics of an economic system. The model may generate high-skill and low-skill equilibria as well as intermediate situations. Policy implications are also discussed.
Multicriteria Prioritization for Multistage Implementation of Complex Urban Renewal Projects
2015
Renewal projects on neighborhood scale often include several sub projects aiming at fulfill the different functions of urban areas, while public funds or activated public-private partnership can be insufficient to face the implementation of subprojects simultaneously. Therefore single parts of wider projects are frequently realized at different period of time, according to the availability of public funds or the interest of private partners in the most profitable projects. Although a major organizational effort of funding could be necessary, a more rational approach is required, which will be able to identify the most suitable sequence of realization ensuring the greatest advantage if non c…