Search results for " rese"
showing 10 items of 14841 documents
Targeting the mevalonate pathway for improved anticancer therapy.
2009
The mevalonate pathway is important for the generation of isoprene moieties thereby providing the basis for the biosynthesis of molecules required for maintaining membrane integrity, steroid production and cell respiration. Additionally, isoprene precursors are indispensable for the prenylation of regulatory proteins such as Ras and Ras-homologous (Rho) GTPases. These low molecular GTP-binding proteins play key roles in numerous signal transduction pathways stimulated upon activation of cell surface receptors by ligand binding. Thus, Ras/Rho proteins eventually regulate cell proliferation, tumor progression and cell death induced by anticancer therapeutics. Lipid modification of Ras/Rho pro…
A novel microtubule de-stabilizing complementarity-determining region C36L1 peptide displays antitumor activity against melanoma in vitro and in vivo
2015
AbstractShort peptide sequences from complementarity-determining regions (CDRs) of different immunoglobulins may exert anti-infective, immunomodulatory and antitumor activities regardless of the specificity of the original monoclonal antibody (mAb). In this sense, they resemble early molecules of innate immunity. C36L1 was identified as a bioactive light-chain CDR1 peptide by screening 19 conserved CDR sequences targeting murine B16F10-Nex2 melanoma. The 17-amino acid peptide is readily taken up by melanoma cells and acts on microtubules causing depolymerization, stress of the endoplasmic reticulum and intrinsic apoptosis. At low concentrations, C36L1 inhibited migration, invasion and proli…
Rho GTPases: Promising Cellular Targets for Novel Anticancer Drugs
2006
Ras-homologous (Rho) GTPases play a pivotal role in the regulation of numerous cellular functions associated with malignant transformation and metastasis. Rho GTPases are localized at membranes and become activated upon stimulation of cell surface receptors. In their GTP-bound (=active) state, Rho proteins bind to effector proteins, thereby triggering specific cellular responses. Members of the Rho family of small GTPases are key regulators of actin reorganization, cell motility, cell-cell and cell-extracellular matrix (ECM) adhesion as well as of cell cycle progression, gene expression and apoptosis. Each of these functions is of importance for the development and progression of cancer. Fu…
Lovastatin inhibits Rho-regulated expression of E-selectin by TNFalpha and attenuates tumor cell adhesion.
2003
E-selectin mediated cell-cell adhesion plays an important role in inflammatory processes and extravasation of tumor cells. Tumor necrosis factor-alpha (TNF-alpha) induces E-selectin gene and protein expression in primary human endothelial cells (HUVEC) and in an endothelial cell line (EA.hy-926). As shown by ELISA and FACS analyses, HMG-CoA reductase inhibitors (e.g., lovastatin) impair the TNF-alpha stimulated increase in E-selectin protein expression. Similar results were obtained for E-selectin mRNA expression and promoter activity, indicating that the effect of lovastatin is based on inhibition of gene expression. The effective inhibitory concentration of lovastatin was in a physiologic…
CONOSCENZA E CONSERVAZIONE. PROSPETTIVE PER LE DOMUS DI PIAZZA DELLA VITTORIA A PALERMO.
2014
Il tema di ricerca possiede un carattere multidisciplinare, coinvolge ampi settori e, con un approccio metodologico di tipo olistico, mette in evidenza le complessità storiche, artistiche, architettoniche, archeologiche e urbanistiche, tenendo conto delle differenti implicazioni sul piano sia tecnologico che museografico. Il caso di studio scelto, per elaborare una strategia d’intervento e riproponibile in altri contesti, è costituito dalle Domus di Piazza della Vittoria a Palermo, un exemplum di complesso residenziale unico nell’ambito della città, arricchito dalla presenza di importanti mosaici che testimoniano la circolazione di possibili culti praticati nell’area occidentale della Sicil…
Nascita e sviluppo della ricerca empirica in campo didattico in Italia
2015
Si ritiene che la ricerca didattica in Italia si sia riavviata intorno al 1950 per il contatto con le scuole statunitensi, per la diffusione delle opere di Dewey e per la nascita dell’Istituto Superiore di Pedagogia della congregazione salesiana. Si ricostruisce il periodo pioneristico della ricerca empirica in campo didattico con il contributo di Calonghi e Visalberghi. Si segnalano alcuni eventi significativi che, intorno alla metà degli anni Settanta, contribuirono all’affermazione della Didattica come scienza dell’insegnamento-apprendimento. Si indicano le principali linee di ricerca empirica in Didattica presenti nell’attuale panorama scientifico italiano.
L’arte come pratica di ricerca e azione. Pratiche di co-creazione artistica per la conoscenza, interpretazione, trasformazioni dell’urbano. Note a pa…
2020
L’arte e le pratiche artistiche sono al centro di questa riflessione, come oggetto d’indagine e come processo epistemologico e metodologico altro, con l’obiettivo di comprendere come possano concorrere a una lettura, interpretazione, attivazione e trasformazione dell’urbano. Muovendoci entro la cornice teorica della ricerca azione partecipativa art-based, il contributo attraverso l’esperienza di SITI e del progetto CAP_04015 intende analizzare come l’arte, come metodologia di ricerca sulla città e come strumento progettuale, possa integrare la ricerca urbana generando processi di riappropriazione e trasformazione, configurandosi come dispositivo per la produzione di territorio. Art and art…
Are subjective outcomes a “missing link” between driving stress and risky driving behaviors of commuters? Assessing the case of a LMIC
2023
Despite the efforts made by different stakeholders, most of Low and Middle-Income Countries (LMICs) continue to systematically report very negative road safety outcomes. In fact, in countries like Colombia, the rate of deaths from traffic crashes has increased in recent years. One of the most affected collectives in this regard -and at the same time one of the least addressed in specialized literature- are driving commuters, which are commonly exposed to several types of threats and stressors configuring an “everyday risk” potentially impairing their health and safety. This study aimed to assess whether there exists an indirect path -mediated by subjective outcomes- linking driving stress a…
Standardization of Road Danger Signs in the European Union
2015
The aim of this research is to find a solution for the standardization of road signs in the EU zone by a comparative analysis of different national sign systems to establish a common set from a single country. This work is based on the idea that road sign standardization might increase the safety level of transnational journeys and foster the relationships among the various members of the EU Community. This paper presents the outcome of the first step of the research, which focuses on the harmonization of danger signs. In more detail, a multicriteria approach is applied to rank 19 EU Member States on the basis of three main aspects: the installation cost of new signs, new sign learning issu…