Search results for " rese"
showing 10 items of 14841 documents
Analysis of Exosomal Cargo Provides Accurate Clinical, Histologic and Mutational Information in Non-Small Cell Lung Cancer
2022
Simple Summary Non-small cell lung cancer (NSCLC) is the second most commonly diagnosed cancer and the leading cause of cancer-related death worldwide. Clinical decision-making depends on the histological classification; however, tissue biopsy is frequently not technically feasible due to tumor location or limited tissue samples. Therefore, we propose to find clinical, molecular and histological biomarkers using a minimally invasive approach based on the analysis of the cargo of the blood extracellular vesicles. Exosomes are membranous vesicles present in several biological fluids, which carry biological information to distant tissues, regulating several tumor processes. This study aims to …
Management of Early Glottic Cancer Treated by CO2 Laser According to Surgical-Margin Status: A Systematic Review of the Literature
2021
Abstract Introduction Transoral laser microsurgery (TLM) is the treatment of choice for Tis-T2 squamous cell glottic carcinomas due to its advantages compared with open surgery and radiotherapy. However, the CO2 laser beam causes changes and damage on the specimens, making the histological assessment of resection margins, the gold standard for confirming radical tumor resection, sometimes difficult. Objective To assess the different ways to manage patients depending on the status of the histopathological margin according to recent studies to detect the most commonly shared therapeutic strategy. Data Synthesis We analyzed the literature available on the PubMed and Web of Science databases, i…
Absence of Adverse Effects of Tiotropium/Olodaterol Compared with the Monocomponents on Long-Term Heart Rate and Blood Pressure in Patients with Mode…
2020
Stefan Andreas,1,2 Lorcan McGarvey,3 Ulrich Bothner,4 Matthias Trampisch,4 Alberto de la Hoz,4 Matjaz Fležar,5 Roland Buhl,6 Peter Alter7 1Department of Cardiology and Pneumology, University Medical Center Göttingen, Göttingen, Germany; 2LungClinic Immenhausen, Immenhausen, Germany, Member of the German Center for Lung Research (DZL); 3Queen’s University Belfast, Belfast, UK; 4Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany; 5Klinika Golnik, Golnik, Slovenia; 6Pulmonary Department, Johannes Gutenberg University Mainz, Mainz, Germany; 7Department of Medicine, Pulmonary and Critical Care Medicine, Philipps University of Marburg (UMR); Member o…
Agreement and disagreement between expectations and realizations
1990
The objective of the paper is to measure the intensity of the relation between expectations and realizations for strategic variables of firms, such as production, demand or prices. An anticipation error reveals a disagreement which can be associated with the rational expectations hypothesis. The agreement coefficient between classifications, given by COHEN (1968) and LIGHT (1971) and calculated from a probability matrix, is used to define a direct measure of the disagreement between classifications. Comparison of the coefficients is used to test the rational expectations hypothesis.The coefficients are applied to business survey data of INSEE for France between 1974 and 1986.
Recursive estimators 1
1991
In this paper, we present first the recursive estimation of parameters of linear regression models and we show the link between a matrix of projection and a matrix of gain. Two cases are examined : constant parameters and parameters changing over time. In the second part the recursion formulae for the two stage least squares are given.
Des capacités de choix aux probabilités de choix (un théorème de conversion)
1992
Une partie importante de la théorie des choix discrets concerne les développements du modèle de Luce 1959]. Cette place privilégiée provient sans nul doute de l’extrême élégance de PAxiome du Choix qui permet d’une part, d’introduire une sorte de rationalité imparfaite du comportement en autorisant la construction de probabilités de choix et d’autre part, de décrire un processus de choix qui semble raisonnablement réaliste : en effet, il est suggéré que l’agent faisant face à un ensemble fini d’actions, choisit dans un premier temps un sous-ensemble, puis finalement, à l ’intérieur de ce sous-ensemble, une action. Il existe de nombreuses versions de ce modèle ( Yellot [1977], Strauss [1980]…
La combinaison de prévisions multiples en présence d'objectifs multiples
1989
L'idée de combiner plusieurs prédicteurs pour générer des prévisions combinées plus fiables semble ne dater que de 1969, date de la publication de l'article de Bâtes et Granger (1969). Depuis lors on a constaté un foisonnement de publications tant théoriques qu'empiriques dans ce domaine et l'utilité pratique de la combinaison de prévisions individuelles y a été amplement démontrée.
Efficient regio- and stereoselective access to novel fluorinated ?-aminocyclohexanecarboxylates
2013
A regio- and stereoselective method has been developed for the synthesis of novel fluorinated 2-aminocyclohexanecarboxylic acid derivatives with the fluorine attached to position 4 of the ring. The synthesis starts from either cis- or trans-β-aminocyclohex-4-enecarboxylic acids and involves regio- and stereoselective transformation of the ring C–C double bond through iodooxazine formation and hydroxylation, followed by hydroxy–fluorine or oxo–fluorine exchange.
Brand social representations: strategic perspectives for a fitness club
2009
International audience; The aim of this study was to identify an accurate tool to enable fitness club managers to discover those opinions or stereotypes which represent obstacles to joining their organisations. Starting with brand image, the analysis then considered social representations as relevant constructs for apprehending these opinions or prejudices. The use of a word association task and the model of basic cognitive schemes (Rouquette, 1990; 1994) provided access to the salient elements of the social representations of a particular sport brand and the way they are structured. The procedure combining these two stages represented a diagnostic tool for identifying the attractive and un…
Representations of nationality in Carl Barks' Lost in the Andes and Voodoo hoodoo
2013
Tutkielman tarkoituksena oli selvittää, miten kansallisuus ja ei-amerikkalaiset hahmot on esitetty Carl Barksin ankkatarinoissa Lost in the Andes ja Voodoo Hoodoo. Tutkielman perustana toimivat Scott McCloudin ja Juha Herkmanin sarjakuvia käsittelevät teokset sekä kansallisten stereotypioiden tutkimus. Sarjakuvat analysoitiin hyödyntäen McCloudin ja Herkmanin määritelmiä sarjakuvien eri elementeistä. Tutkimuksessa kävi ilmi, että paikalliset, ei-yhdysvaltalaiset hahmot on kuvattu yksipuolisesti, miesvaltaisesti ja muutamaa piirrettä korostaen kunkin kansallisuuden kohdalla. Esilletulleita seikkoja olivat muunmuassa hahmojen vaatetus, kasvonpiirteet, luonne sekä käyttäytyminen. Nämä piirteet…