Search results for " research"
showing 10 items of 14115 documents
The roles of whole-genome and small-scale duplications in the functional specialization of Saccharomyces cerevisiae genes
2013
Researchers have long been enthralled with the idea that gene duplication can generate novel functions, crediting this process with great evolutionary importance. Empirical data shows that whole-genome duplications (WGDs) are more likely to be retained than small-scale duplications (SSDs), though their relative contribution to the functional fate of duplicates remains unexplored. Using the map of genetic interactions and the re-sequencing of 27 Saccharomyces cerevisiae genomes evolving for 2,200 generations we show that SSD-duplicates lead to neo-functionalization while WGD-duplicates partition ancestral functions. This conclusion is supported by: (a) SSD-duplicates establish more genetic i…
Selection for Robustness in Mutagenized RNA Viruses
2007
Mutational robustness is defined as the constancy of a phenotype in the face of deleterious mutations. Whether robustness can be directly favored by natural selection remains controversial. Theory and in silico experiments predict that, at high mutation rates, slow-replicating genotypes can potentially outcompete faster counterparts if they benefit from a higher robustness. Here, we experimentally validate this hypothesis, dubbed the ‘‘survival of the flattest,’’ using two populations of the vesicular stomatitis RNA virus. Characterization of fitness distributions and genetic variability indicated that one population showed a higher replication rate, whereas the other was more robust to mut…
Spatial Variation of Leaf Optical Properties in a Boreal Forest Is Influenced by Species and Light Environment
2017
Leaf Optical Properties (LOPs) convey information relating to temporally dynamic photosynthetic activity and biochemistry. LOPs are also sensitive to variability in anatomically related traits such as Specific Leaf Area (SLA), via the interplay of intra-leaf light scattering and absorption processes. Therefore, variability in such traits, which may demonstrate little plasticity over time, potentially disrupts remote sensing estimates of photosynthesis or biochemistry across space. To help to disentangle the various factors that contribute to the variability of LOPs, we defined baseline variation as variation in LOPs that occurs across space, but not time. Next we hypothesized that there wer…
Evaluating structural and compositional canopy characteristics to predict the light-demand signature of the forest understorey in mixed, semi-natural…
2020
Questions: Light availability at the forest floor affects many forest ecosystem processes, and is often quantified indirectly through easy-to-measure stand characteristics. We investigated how three such characteristics, basal area, canopy cover and canopy closure, were related to each other in structurally complex mixed forests. We also asked how well they can predict the light-demand signature of the forest understorey (estimated as the mean Ellenberg indicator value for light [“EIVLIGHT”] and the proportion of “forest specialists” [“%FS”] within the plots). Furthermore, we asked whether accounting for the shade-casting ability of individual canopy species could improve predictions of EIV…
A physiology-based Earth observation model indicates stagnation in the global gross primary production during recent decades
2020
Abstract Earth observation‐based estimates of global gross primary production (GPP) are essential for understanding the response of the terrestrial biosphere to climatic change and other anthropogenic forcing. In this study, we attempt an ecosystem‐level physiological approach of estimating GPP using an asymptotic light response function (LRF) between GPP and incoming photosynthetically active radiation (PAR) that better represents the response observed at high spatiotemporal resolutions than the conventional light use efficiency approach. Modelled GPP is thereafter constrained with meteorological and hydrological variables. The variability in field‐observed GPP, net primary productivity an…
Accounting for species interactions is necessary for predicting how arctic arthropod communities respond to climate change
2021
Species interactions are known to structure ecological communities. Still, the influence of climate change on biodiversity has primarily been evaluated by correlating individual species distributions with local climatic descriptors, then extrapolating into future climate scenarios. We ask whether predictions on arctic arthropod response to climate change can be improved by accounting for species interactions. For this, we use a 14-year-long, weekly time series from Greenland, resolved to the species level by mitogenome mapping. During the study period, temperature increased by 2 degrees C and arthropod species richness halved. We show that with abiotic variables alone, we are essentially un…
Accounting for preferential sampling in species distribution models
2019
D. C., A. L. Q. and F. M. would like to thank the Ministerio de Educación y Ciencia (Spain) for financial support (jointly financed by the European Regional Development Fund) via Research Grants MTM2013‐42323‐P and MTM2016‐77501‐P, and ACOMP/2015/202 from Generalitat Valenciana (Spain). Species distribution models (SDMs) are now being widely used in ecology for management and conservation purposes across terrestrial, freshwater, and marine realms. The increasing interest in SDMs has drawn the attention of ecologists to spatial models and, in particular, to geostatistical models, which are used to associate observations of species occurrence or abundance with environmental covariates in a fi…
The cost of open access publication of papers by spanish authors in five areas of the social sciences
2021
[ES] La publicación en abierto de los artículos conlleva unos gastos conocidos como cargos por procesamiento de artículos (APC, en sus siglas en inglés). El objetivo de este trabajo es determinar el coste de los artículos publicados en abierto mediante APC de autoría española en cinco categorías temáticas de las ciencias sociales: Humanities (Multidisciplinary), Sociology, Information Science & Library Science, Education & Educational Research y Communication de la Colección Principal de la Web of Science (WoS) durante el periodo 2012-2019. Se han identificado las revistas, las instituciones financiadoras y los modelos de publicación más frecuentes. El estudio indica que de las 223 revistas…
Fine‐grain beta diversity of Palaearctic grassland vegetation
2021
QUESTIONS: Which environmental factors influence fine-grain beta diversity of vegetation and do they vary among taxonomic groups? LOCATION: Palaearctic biogeographic realm. METHODS: We extracted 4,654 nested-plot series with at least four different grain sizes between 0.0001 m² and 1,024 m² from the GrassPlot database, covering a wide range of different grassland and other open habitat types. We derived extensive environmental and structural information for these series. For each series and four taxonomic groups (vascular plants, bryophytes, lichens, all), we calculated the slope parameter (z-value) of the power law species–area relationship (SAR), as a beta diversity measure. We tested whe…
Collateral sensitivity of natural products in drug-resistant cancer cells
2018
Cancer chemotherapy is frequently hampered by drug resistance. Concepts to combine anticancer drugs with different modes of action to avoid the development of resistance did not provide the expected success in the past, because tumors can be simultaneously non-responsive to many drugs (e.g. the multidrug resistance phenotype). However, tumors may be specifically hypersensitive to other drugs - a phenomenon also termed collateral sensitivity. This seems to be a general biological mechanism, since it also occurs in drug-resistant Escherichia coli and Saccharomyces cerevisiae. Here, we give a timely and comprehensive overview on hypersensitivity in resistant cancer cells towards natural produc…