Search results for " response"
showing 7 items of 2127 documents
Autophagy is induced by resistance exercise in young men but unfolded protein response is induced regardless of age
2018
Aim Autophagy and unfolded protein response (UPR) appear to be important for skeletal muscle homoeostasis and may be altered by exercise. Our aim was to investigate the effects of resistance exercise and training on indicators of UPR and autophagy in healthy untrained young men (n = 12, 27 ± 4 years) and older men (n = 8, 61 ± 6 years) as well as in resistance‐trained individuals (n = 15, 25 ± 5 years). Methods Indicators of autophagy and UPR were investigated from the muscle biopsies after a single resistance exercise bout and after 21 weeks of resistance training. Results Lipidated LC3II as an indicator of autophagosome content increased at 48 hours post‐resistance exercise (P < .05) and …
Finnish athletes' expectations about physiotherapy in sport injury rehabilitation
2011
As the injured athlete's primary and most frequent contact within the sport injury rehabilitation process, the physiotherapist is in a unique position to influence the athlete's psychological rehabilitation alongside the physical recovery (Barefield & McCallister, 1997). The important question of whether or not athletes expect physiotherapists to address their psychological issues, however, has not yet been investigated in detail. Moreover, scales that measure athletes’ expectations of physiotherapy are also scarce and available only in the English language. Therefore, the purpose of this study was two-fold: 1) to adapt the Expectation About Athletic Training (EAAT) questionnaire into Finni…
Predator-Induced Plasticity on Warning Signal and Larval Life-History Traits of the Aposematic Wood Tiger Moth, Arctia plantaginis
2021
Correction Frontiers in Ecology and Evolution Volume 9 Article Number 737651 DOI 10.3389/fevo.2021.737651 Published JUL 29 2021 Predator-induced plasticity in life-history and antipredator traits during the larval period has been extensively studied in organisms with complex life-histories. However, it is unclear whether different levels of predation could induce warning signals in aposematic organisms. Here, we investigated whether predator-simulated handling affects warning coloration and life-history traits in the aposematic wood tiger moth larva, Arctia plantaginis. As juveniles, a larger orange patch on an otherwise black body signifies a more efficient warning signal against predators…
Immune responses during COVID-19 infection
2020
International audience; Over the past 16 years, three coronaviruses (CoVs), severe acute respiratory syndrome CoV (SARS-CoV) in 2002, Middle East respiratory syndrome CoV (MERS-CoV) in 2012 and 2015, and SARS-CoV-2 in 2020, have been causing severe and fatal human epidemics. The unpredictability of coronavirus disease-19 (COVID-19) poses a major burden on health care and economic systems across the world. This is caused by the paucity of in-depth knowledge of the risk factors for severe COVID-19, insufficient diagnostic tools for the detection of SARS-CoV-2, as well as the absence of specific and effective drug treatments. While protective humoral and cellular immune responses are usually m…
STAT1 and Its Crucial Role in the Control of Viral Infections
2022
The signal transducer and activator of transcription (STAT) 1 protein plays a key role in the immune response against viruses and other pathogens by transducing, in the nucleus, the signal from type I, type II and type III IFNs. STAT1 activates the transcription of hundreds of genes, some of which have been well characterized for their antiviral properties. STAT1 gene deletion in mice and complete STAT1 deficiency in humans both cause rapid death from severe infections. STAT1 plays a key role in the immunoglobulin class-switch recombination through the upregulation of T-bet; it also plays a key role in the production of T-bet+ memory B cells that contribute to tissue-resident humoral memory…
Beyond early: Decision support for improved typhoon warning systems
2015
International audience; Warnings can help prevent damage and harm if they are issued timely and provide information that help responders and population to adequately prepare for the disaster to come. Today, there are many indicator and sensor systems that are designed to reduce disaster risks, or issue early warnings. In this paper we analyze the different systems in the light of the initial decisions that need to be made in the response to sudden onset disasters. We outline challenges of current practices and methods, and provide an agenda for future research.To illustrate our approach, we present a case study of Typhoon Haiyan. Although meteorological services had issued warnings; relief …