Search results for " s.p.a."
showing 10 items of 253 documents
Hypothesis: Etiologic and Molecular Mechanistic Leads for Sporadic Neurodegenerative Diseases Based on Experience With Western Pacific ALS/PDC
2019
Seventy years of research on Western Pacific amyotrophic lateral sclerosis and Parkinsonism-dementia Complex (ALS/PDC) have provided invaluable data on the etiology, molecular pathogenesis and latency of this disappearing, largely environmental neurodegenerative disease. ALS/PDC is linked to genotoxic chemicals (notably methylazoxymethanol, MAM) derived from seed of the cycad plant (Cycas spp.) that were used as a traditional food and/or medicine in all three disease-affected Western Pacific populations. MAM, nitrosamines and hydrazines generate methyl free radicals that damage DNA (in the form of O6-methylguanine lesions) that can induce mutations in cycling cells and degenerative changes …
Genomic characterization of the Braque Français type Pyrénées dog and relationship with other breeds
2018
The evaluation of genetic variability is a useful research tool for the correct management of selection and conservation strategies in dog breeds. In addition to pedigree genealogies, genomic data allow a deeper knowledge of the variability and genetic structure of populations. To date, many dog breeds, such as small regional breeds, still remain uncharacterized. Braque Français type Pyrénées (BRA) is a dog breed originating from a very old type of gun-dog used for pointing the location of game birds to hunters. Despite the ancient background, the knowledge about levels of genetic diversity, degree of inbreeding and population structure is scarce. This may raise concerns on the possibility …
Automated Categorization of Parkinsonian Syndromes Using Magnetic Resonance Imaging in a Clinical Setting
2020
Background Machine learning algorithms using magnetic resonance imaging (MRI) data can accurately discriminate parkinsonian syndromes. Validation in patients recruited in routine clinical practice is missing. Objective The aim of this study was to assess the accuracy of a machine learning algorithm trained on a research cohort and tested on an independent clinical replication cohort for the categorization of parkinsonian syndromes. Methods Three hundred twenty-two subjects, including 94 healthy control subjects, 119 patients with Parkinson's disease (PD), 51 patients with progressive supranuclear palsy (PSP) with Richardson's syndrome, 35 with multiple system atrophy (MSA) of the parkinsoni…
Modulating disease-relevant tau oligomeric strains by small molecules
2020
The pathological aggregation of tau plays an important role in Alzheimer's disease and many other related neurodegenerative diseases, collectively referred to as tauopathies. Recent evidence has demonstrated that tau oligomers, small and soluble prefibrillar aggregates, are highly toxic due to their strong ability to seed tau misfolding and propagate the pathology seen across different neurodegenerative diseases. We previously showed that novel curcumin derivatives affect preformed tau oligomer aggregation pathways by promoting the formation of more aggregated and nontoxic tau aggregates. To further investigate their therapeutic potential, we have extended our studies o disease-relevant bra…
Superfluorinated ionic liquid crystals based on supramolecular, halogen-bonded anions
2016
Unconventional ionic liquid crystals in which the liquid crystallinity is enabled by halogen-bonded supramolecular anions [CnF2 n+1-I⋯I⋯I-CnF2 n+1]- are reported. The material system is unique in many ways, demonstrating for the first time 1) ionic, halogen-bonded liquid crystals, and 2) imidazolium-based ionic liquid crystals in which the occurrence of liquid crystallinity is not driven by the alkyl chains of the cation. Out of the ordinary: The high directionality of halogen bonds and the fluorophobic effect were exploited in the design and synthesis of a new family of unconventional superfluorinated ionic liquid crystals. The liquid crystallinity of the system is driven by halogen-bonded…
Nullità sopravvenuta (una breve riflessione propositiva)
2022
Il contributo ha ad oggetto una riflessione propositiva sulla cosiddetta nullità sopravvenuta, valorizzando nei contratti ad efficacia non ancora esaurita la vigenza della fonte. Da ciò può dedursi che in ogni momento e fase dinamica del contratto sia implicito un costante ancoraggio alla sua giustificazione, che imporrebbe una reiterazione del giudizio di validità. Così che per i casi nei quali il contratto si ponga in un secondo momento in contrasto con regole di validità poste dall’ordinamento per effetto di una circostanza successiva alla sua formazione, pur in senso diacronico (rispetto all’origine), sia ravvisabile una ipotesi di nullità successiva
Coronavirus ed esonero da responsabilità per inadempimento di obbligazione ex art. 1218 c.c.: impossibilità sopravvenuta oppure inesigibilità della p…
2020
La crisi economica e la fase emergenziale di questi giorni sollecitano l?attenzione sull?influenza del diffondersi del contagio da Coronavirus sull?esecuzione dei rapporti obbligatori. Con particolare riferimento alla responsabilità del debitore da inadempimento di obbligazione, ex art. 1218 c.c., ci si chiede se l?epidemia COVID-19 , nel determinare l?applicazione di un regime normativo che esclude la relativa imputabilità al debitore, configuri un?ipotesi di impossibilità sopravvenuta oppure di inesigibilità della prestazione. Prima facie, le menzionate figure sembrerebbero coincidere; invero, ad un?analisi più attenta, identificano categorie diverse. Dall?analisi di siffatti profili diff…
Abordaje supracerebeloso transtentorial suprameatal a la totalidad de la región mediobasal del lóbulo temporal
2015
La región mediobasal del lóbulo temporal (RMT), por su compleja anatomía y su localización, constituye a día de hoy un reto neuroquirúrgico de primer orden. El desarrollo de la cirugía microquirúrgica de base craneal y los nuevos horizontes de la cirugía endoscópica siguen sin ofrecer un abordaje óptimo para aquellas lesiones asentadas en la totalidad de la RMT (principalmente oncológicas y vasculares). La exposición parcial de la RMT y el compromiso de estructuras neurovasculares no implicadas en la patología a tratar suponen los principales inconvenientes a la hora de plantear el abordaje de dichas lesiones. Las lesiones con frecuencia tumorales, que afectan la totalidad de la RMT, requie…
Esclerectomía profunda no perforante con espolonectomía e implante supraciliar : una nueva propuesta para la cirugía no penetrante del glaucoma
2013
Actualmente la cirugía del glaucoma se encuentra en evolución. La trabeculectomía es el procedimiento quirúrgico hipotensor más realizado, por lograr grandes disminuciones de la presión intraocular, pero tiene el inconveniente de que al tratarse de un procedimiento penetrante, puede traer consigo mayores complicaciones como la hipotensión y disestesias de la ampolla conjuntival, por ello la cirugía no penetrante goza cada vez de mas defensores. Entre los procedimientos quirúrgicos no penetrantes, la esclerectomía profunda no perforante (EPNP) es la más realizada, con esta técnica el humor acuoso filtra a través de la membrana trabéculodescemética y de allí drena por la vía subconjuntival. S…
Computations on electroactive molecular materials: from donor–acceptor architectures to supramolecular polymers
2017
En la presente tesis, se ha realizado un estudio teórico exhaustivo sobre una gran variedad de sistemas moleculares electroactivos con propiedades ópticas, electónicas y de autoensamblaje interesantes para ser explotadas en electrónica molecular y ciencia de nuevos materiales. Los resultados del trabajo de investigación se resumen en tres secciones de acuerdo con: Arquitecturas dador–acceptor covalentes Se han caracterizado teóricamente las propiedades electrónicas y ópticas de cromóforos dador–aceptor que absorben luz en todo el espectro visible. En particular, los cálculos DFT han proporcionado información sobre los regioisómeros más interesantes de exTTF-DCF para obtener un máximo benefi…