Search results for " salud."
showing 10 items of 1584 documents
Synchronous metastatic cutaneous squamous cell carcinoma and chronic lymphocytic leukaemia/small lymphocytic lymphoma in a cervical lymph node: case …
2015
The synchronous occurrence of two different neoplasias is an uncommon event, which may arise between tumors originating in the same organ or in cancer-to-cancer metastasis. We report a rare case of chronic lymphocytic leukaemia / small lymphocytic lymphoma associated with a cutaneous metastatic squamous cell carcinoma in a cervical lymph node. In the affected lymph node, it was observed an effacement of the normal architecture by neoplastic lymphocytes and it was noted the presence of neoplastic invasive epithelial islands. Immunohistochemical analysis demonstrated that lymphocytic proliferation was positive for CD20, CD5, CD23 and Kappa, and negative for CD3, CD10, Cyclin D1 and Lambda. Th…
Expresión de las moléculas del Complejo Mayor de Histocompatibilidad clase II y moléculas co-estimuladoras en carcinomas orales in vitro
2005
El descubrimiento de que el epitelio escamoso estratificado que cubre la mucosa oral podia expresar moleculas del Complejo Mayor de Histocompatibilidad clase II en varias condiciones patologicas de tipo inflamatorio abrio la posibilidad de que los queratinocitos orales sean celulas inmunologicamente activas, las cuales pueden funcionar con .celulas presentadoras de antigenos'ñ. Para una efectiva activacion de los linfocitos T, las celulas presentadoras de antigenos requieren, ademas de la expresion de moleculas del Complejo Mayor de Histocompatibilidad clase II, senales co-estimuladoras. El proposito del presente estudio fue determinar la expresion de moleculas del Complejo Mayor de Histoco…
Defense Responses in Two Ecotypes of Lotus japonicus against Non-Pathogenic Pseudomonas syringae
2013
Lotus japonicus is a model legume broadly used to study many important processes as nitrogen fixing nodule formation and adaptation to salt stress. However, no studies on the defense responses occurring in this species against invading microorganisms have been carried out at the present. Understanding how this model plant protects itself against pathogens will certainly help to develop more tolerant cultivars in economically important Lotus species as well as in other legumes. In order to uncover the most important defense mechanisms activated upon bacterial attack, we explored in this work the main responses occurring in the phenotypically contrasting ecotypes MG-20 and Gifu B-129 of L. ja…
Los argumentos de los discursos públicos en torno a la controversia de la vacuna contra el VPH
2014
En este capítulo describimos los distintos argumentos esgrimidos en torno a la controversia de la vacuna contra el VPH en los discursos públicos, desde su implantación hasta la actualidad. El principal objetivo de este trabajo ha consistido en sistematizar cuáles han sido los testimonios de quienes han estado a favor y en contra de la vacunación masiva. Hemos registrado los argumentos del discurso oficial de las sociedades científicas y de los expertos que avalaron la puesta en marcha de este programa de vacunación; y, paralelamente, hemos seleccionado los argumentos de los expertos en salud pública que se han posicionado en contra de la vacunación masiva, así como de los miembros de la Aso…
Successful closure of the root apex in non-vital permanent incisors with wide open apices using single calcium hydroxide (caoh) dressing: report of 2…
2010
Endodontic management of immature non vital permanent teeth in young pediatric patients is a great challenge to dentists. The walls of the root canals are frequently divergent and open apexes make debridement and obturation difficult. Thus closure of root apex is very essential for success of the endodontic treatment. Although different materials are used for the apexification procedure, calcium hydroxide is the material of choice for apical barrier formation and healing. There are different opinions regarding frequency of CaOH dressing change to induce complete closure of the apex. Literature suggests that dressing should be changed frequently. Therefore the aim of the present article is t…
Valoración del estado de salud como calidad de vida. Aplicación de la matriz de Rosser en toxicomanías
2002
Se analizan las valoraciones sobre la calidad de vida percibida que un colectivo de personas con adicción a opiáceos realiza respecto a un conjunto de estados de salud, y si dichas valoraciones son equivalentes a las realizadas por un colectivo normativo de usuarios sanos. A través de técnicas de grupo nominal y mediante la aplicación de la matriz de Rosser, 30 personas en tratamiento en un programa de mantenimiento con metadona ofrecen valoraciones de calidad de vida a diferentes estados de salud. Los resultados muestran que la calidad de vida disminuye a medida que el nivel de incapaci¬dad y el nivel de sufrimiento/dolor aumentan, siendo este último el que tiene un mayor peso específico e…
EML4-ALK translocation identification in RNA exosomal cargo (ExoALK) in NSCLC patients: A novel role for liquid biopsy
2019
Abstract: The introduction of druggable targets has significantly improved the outcomes of non-small cell lung cancer patients (NSCLC). EML4-ALK translocation represents 4-6% of the druggable alterations in NSCLC. With the approval of Crizotinib, first discovered drug for the EML4-ALK translocation, on first line treatment for patients with detected mutation meant a complete change on the treatment landscape. The current standard method for EML4-ALK identification is immunohistochemistry or FISH in a tumor biopsy. However, a big number of NSCLC patients have not tissue available for analysis and others are not suitable fir biopsy due to their physical condition or the location of the tumor.…
Prediction of CRT Activation Sequence by Personalization of Biventricular Models from Electroanatomical Maps
2020
[EN] Optimization of lead placement and interventricular delay settings in patients under cardiac resynchronization therapy is a complex task that might benefit from prior information based on models. Biophysical models can be used to predict the sequence of electrical heart activation in a patient given a set of parameters which should be personalized to the patient. In this paper, we use electroanatomical maps to personalize the endocardial activation of the right ventricle, and the different tissue conductivities in a pig model with left bundle branch block, to reproduce personalized biventricular activations. Following, we tested the personalized heart model by virtually simulating card…
All-trans retinoic acid restores gap junctional intercellular communication between oral cancer cells with upregulation of Cx32 and Cx43 expressions …
2012
Objective: All-trans retinoic acid (ATRA) has been demonstrated to inhibit tumor growth by restoration of gap junctional intercellular communication (GJIC) via upregulation of connexin (Cx) expression in some solid tumors. However, the relationship between ATRA and GJIC remains unclear in oral squamous cell carcinoma (OSCC). The aim of this study was to investigate the effect of ATRA on the GJIC function of OSCC. Study design: We measured the effects of ATRA on the viability and cell cycle distribution of SCC9 and Tca8113 OSCC cells. The GJIC function was observed using the scrape-loading dye transfer technique, and the mRNA and protein levels of Cx32 and Cx43 were detected by qRT-PCR, West…
Presence of matrix vesicles in the body of odontoblasts and in the inner third of dentinal tissue: a scanning electron microscopic study.
2012
Objectives: The aim of this report is to present the results of a scanning electron microscopic study on the presence of matrix vesicles (MVs) found in human dentine. Study Design: Dentin tissue from 20 human bicuspids was analyzed by means of scanning electron microscopy. Results: MVs were found as outgrowths of the cellular membrane of the odontoblastic body, the more proximal portion of the odontoblastic process before entering the dentinal tubule and in the odontoblastic process within the inner third of the dentin. Size of MVs varied depending on location. In the inner third of dentin, they were seen in diverse positions; as membranal outgrowths, deriving from the odontoblastic process…