Search results for " secondary"
showing 10 items of 692 documents
Exact simulation of diffusion first exit times: algorithm acceleration
2020
In order to describe or estimate different quantities related to a specific random variable, it is of prime interest to numerically generate such a variate. In specific situations, the exact generation of random variables might be either momentarily unavailable or too expensive in terms of computation time. It therefore needs to be replaced by an approximation procedure. As was previously the case, the ambitious exact simulation of exit times for diffusion processes was unreachable though it concerns many applications in different fields like mathematical finance, neuroscience or reliability. The usual way to describe exit times was to use discretization schemes, that are of course approxim…
Additive functionals and push forward measures under Veretennikov's flow
2014
16 pages; In this work, we will be interested in the push forward measure $(\vf_t)_*\gamma$, where $\vf_t$ is defined by the stochastic differential equation \begin{equation*} d\vf_t(x)=dW_t + \ba(\vf_t(x))dt, \quad \vf_0(x)=x\in\mbR^m, \end{equation*} and $\gamma$ is the standard Gaussian measure. We will prove the existence of density under the hypothesis that the divergence $\div(\ba)$ is not a function, but a signed measure belonging to a Kato class; the density will be expressed with help of the additive functional associated to $\div(\ba)$.
Cut-off method for endogeny of recursive tree processes
2016
Given a solution to a recursive distributional equation, a natural (and non-trivial) question is whether the corresponding recursive tree process is endogenous. That is, whether the random environment almost surely defines the tree process. We propose a new method of proving endogeny, which applies to various processes. As explicit examples, we establish endogeny of the random metrics on non-pivotal hierarchical graphs defined by multiplicative cascades and of mean-field optimization problems as the mean-field matching and travelling salesman problems in pseudo-dimension q>1.
Evaluation of a public policy for combating exclusions : the case of an "insertion" class in the final year of junior secondary school
2005
Since 1975, the expression "single college" is regularly evoked to describe the first cycle of secondary education in France. However, since 1992, classes named "third of insertion", neither dedicated to general education, nor assimilable to those with adapted teaching have been functioning for mailing pupils. At the cross-roads of political, historical, economic and social problems, this study tries to articulate each one of these fields, with the student body, placed at the centre of these questions, being both from an underprivileged social category and having experienced school failure. The analysis which follows demands simultaneously research on the concept of "insertion", the name of…
Molecular mechanisms of primary and secondary mucosal immunity using avian infectious bronchitis virus as a model system
2007
Although mucosal immune responses are critical for protection of hosts from clinical illness and even mortality caused by mucosal pathogens, the molecular mechanism of mucosal immunity, which is independent of systemic immunity, remains elusive. To explore the mechanistic basis of mucosal protective immunity, gene transcriptional profiling in mucosal tissues was evaluated after the primary and secondary immunization of animals with an attenuated avian infectious bronchitis virus (IBV), a prototype of Coronavirus and a well-characterized mucosal pathogen. Results showed that a number of innate immune factors including toll-like receptors (TLRs), retinoic-acid-inducible gene-1 (RIG-1), type I…
Procollagen C-proteinase Enhancer Stimulates Procollagen Processing by Binding to the C-propeptide Region Only*
2011
Background: Procollagen C-proteinase enhancer-1 (PCPE-1) is an extracellular glycoprotein that increases activity of certain zinc metalloproteinases involved in tissue development and repair. Results: PCPE-1 binds uniquely to the C-propeptide region of the procollagen molecule. Conclusion: PCPE-1 enhances proteolysis by binding solely to the procollagen C-propeptides. Significance: These data may lead to future applications in the development of antifibrotic therapies.
Repositioning teachers as assessors : Compromised aspirations and contested agency
2021
The global trend to emphasise assessment for learning brings up the issue of repositioning teachers in assessment. The contemporary curricular policy reforms encourage teachers to take an agentic role in assessment, but multiple dimensions of the environment affect its realisation. Drawing on an ecological approach to teacher agency, this empirical study investigated how Korean secondary English teachers (KSETs) perceive and enact their own teacher agency in assessment within the ecosystem of Korean education. The dataset for the study comprises semi-structured interviews with 15 KSETs. The interview questions involved the main themes such as personal experiences over the life course regard…
The Co-developmental Dynamic of Sport and School Burnout among Student-Athletes : The Role of Achievement Goals
2018
Student‐athletes who strive for success in high‐level sports while pursuing upper secondary education may be prone to sport and school burnout. This study examined the co‐developmental dynamic of sport and school burnout in Finnish adolescent student‐athletes (Ntime 1 = 391; Ntime 2 = 373) across the first year of upper secondary school using cross‐lagged structural equation modeling (SEM). Furthermore, we used sport and school‐related achievement goals as predictors of sport and school burnout, namely sport and school‐related exhaustion, cynicism, and feelings of inadequacy. The results showed that burnout dimensions in a particular domain were substantially stable within the same domain d…
High Resolution Solution NMR Structure of the Z Domain of Staphylococcal Protein A. Analysis of Secondary Structure for Free Z Domain and Bounded to …
1997
Staphylococcal protein A (SpA) is a cell-wall-bound pathogenicity factor from the bacterium Staphylcoccus aureus. It exhibits tight binding to many IgG, IgA and IgM molecules at site(s) different from antigen-combining site. Because of their small size and immunoglobulin (IgG)-binding activities, domains of protein A are important targets for protein engineering efforts and for the development of computational approaches for de novo protein folding.
Drug Binding Properties of Tyrosine-Modified Human Serum Albumin
1978
Human serum albumin (HSA) has only a small number of specific binding sites for drugs. There are facts indicating that tyrosine residues may be involved in these binding sites. Thus we modified HSA with tetranitromethan, a reagent specific for tyrosine residues in proteins. As derived from an UV-absorption quotient three albumins with a degree of modification of two, five and eight residues per molecule were obtained. Only for the albumin with eight residues modified a small reduction of ordered secondary structure was found.