Search results for " security"
showing 10 items of 1419 documents
A clustering package for nucleotide sequences using Laplacian Eigenmaps and Gaussian Mixture Model.
2018
International audience; In this article, a new Python package for nucleotide sequences clustering is proposed. This package, freely available on-line, implements a Laplacian eigenmap embedding and a Gaussian Mixture Model for DNA clustering. It takes nucleotide sequences as input, and produces the optimal number of clusters along with a relevant visualization. Despite the fact that we did not optimise the computational speed, our method still performs reasonably well in practice. Our focus was mainly on data analytics and accuracy and as a result, our approach outperforms the state of the art, even in the case of divergent sequences. Furthermore, an a priori knowledge on the number of clust…
panISa: ab initio detection of insertion sequences in bacterial genomes from short read sequence data.
2018
Abstract Motivation The advent of next-generation sequencing has boosted the analysis of bacterial genome evolution. Insertion sequence (IS) elements play a key role in prokaryotic genome organization and evolution, but their repetitions in genomes complicate their detection from short-read data. Results PanISa is a software pipeline that identifies IS insertions ab initio in bacterial genomes from short-read data. It is a highly sensitive and precise tool based on the detection of read-mapping patterns at the insertion site. PanISa performs better than existing IS detection systems as it is based on a database-free approach. We applied it to a high-risk clone lineage of the pathogenic spec…
Simulation-based estimation of branching models for LTR retrotransposons
2017
Abstract Motivation LTR retrotransposons are mobile elements that are able, like retroviruses, to copy and move inside eukaryotic genomes. In the present work, we propose a branching model for studying the propagation of LTR retrotransposons in these genomes. This model allows us to take into account both the positions and the degradation level of LTR retrotransposons copies. In our model, the duplication rate is also allowed to vary with the degradation level. Results Various functions have been implemented in order to simulate their spread and visualization tools are proposed. Based on these simulation tools, we have developed a first method to evaluate the parameters of this propagation …
Decentralised trust-management inspired by ant pheromones
2017
Computational trust is increasingly utilised to select interaction partners in open technical systems consisting of heterogeneous, autonomous agents. Current approaches rely on centralised elements for managing trust ratings (i.e. control and provide access to aggregated ratings). Consider a grid computing application as illustrating example: agents share their computing resources and cooperate in terms of processing computing jobs. These agents are free to join and leave, and they decide on their own with whom to interact. The impact of malicious or uncooperative agents can be countered by only cooperating with agents that have shown to be benevolent: trust relationships are established. T…
Graphical Workflow System for Modification Calling by Machine Learning of Reverse Transcription Signatures
2019
Modification mapping from cDNA data has become a tremendously important approach in epitranscriptomics. So-called reverse transcription signatures in cDNA contain information on the position and nature of their causative RNA modifications. Data mining of, e.g. Illumina-based high-throughput sequencing data, is therefore fast growing in importance, and the field is still lacking effective tools. Here we present a versatile user-friendly graphical workflow system for modification calling based on machine learning. The workflow commences with a principal module for trimming, mapping, and postprocessing. The latter includes a quantification of mismatch and arrest rates with single-nucleotide re…
People with Disabilities and Disasters
2017
Investigations have collectively established that disasters affect people with disabilities both disproportionately and negatively. In addition, perceived disability status is often associated with stigma, creating a separate and unique barrier across societies and cultures, which can augment vulnerability to disasters. Relevant research is reviewed by academic genesis areas in this chapter, namely; 1) disaster-focused research, 2) mental health, 3) epidemiology and public health, and 4) disability studies. Research emanating from these disciplines reflects different epistemological assumptions about disability as well as varying knowledge about disability as a social and cultural const…
The influence of corporate governance's decision on corporate social responsibility
2018
The need for an accurate and detailed disclosure, the need to understand the mechanisms of government under which the company is managed and controlled, are the starting point of the choices of the many stakeholders that revolve around the company. A large number of players is interested in corporate governance are among these, not only the major shareholders, but also an increasing number of small investors. CSR is an extension of firms efforts to foster effective corporate governance, ensuring firms sustainability via sound business practices that promote accountability and transparency. rnThe paper aims to explore the impact that various corporate governance mechanisms have on the commit…
Cimo: An efficient 2-phases calculator of multimodal itineraries for real trans-territories based on a dynamic programming
2015
In this work we propose an exact solution for calculating multimodal itinerary. This solution is named Cimo (Calculateur d'Itineraires Multimodaux Ordonnes). Cimo is an exact optimal itineraries' calculator wherein itineraries are sorted, multimodal, and trans-territorial. The solution is based on a dynamic programming algorithm "cut", "price" and "share". This solution is multi-objectives and multi-constraints. Several versions of this algorithm are proposed following a methodological approach that enables evaluation of efficiency and complexity's gain : through theoretical calculus and benchmarks. In the first version of realistic problem, we propose a solution with itineraries calculated…
Transport engineering and reduction in crime: the Medellín case
2016
This study analyses the impact of the aerial cable car public transport system, locally known as Metrocable, in Medellín (Colombia), on the reduction in crime. As part of the municipal policies of social urbanism, Metrocable has contributed to the social integration of the population in the outlying neighbourhoods, which has increased safety in Medellín. This case is clearly of great interest from the point of view of Criminal Sciences, demonstrating how crime can be combated by using tools beyond ius puniendi. DOI: http://dx.doi.org/10.4995/CIT2016.2016.3434
The Sociology of Nazism
1994
In a previous paper, we tested a number of critical hypotheses derived from the three principal explanations of the sociology of Nazism. Our major finding was that the mass society, lower middle-class party of protest, and political confessionalism theses are empirically flawed. In this article, we apply an interest-based theory to the sociology of blue-collar Nazism. Using a sample of 15,006 workers who joined the Nazi Party between 1925 and 1932, we test the validity of our interest-based theory. The data demonstrate significant support for an interest-based account of Nazi Party working-class joining.