Search results for " sensitivity"

Fragments of β-thymosin from the sea urchin Paracentrotus lividus as potential antimicrobial peptides against staphylococcal biofilms.

2012

The immune mediators in echinoderms can be a potential source of novel antimicrobial peptides (AMPs) applied toward controlling pathogenic staphylococcal biofilms that are intrinsically resistant to conventional antibiotics. The peptide fraction5 kDa from the cytosol of coelomocytes of the sea urchin Paracentrotus lividus (5-CC) was tested against a group of Gram-positive and Gram-negative pathogen reference strains. The 5-CC of P. lividus was active against all planktonic-tested strains but also showed antibiofilm properties against staphylococcal strains. Additionally, we demonstrated the presence of three small peptides in the 5-CC belonging to segment 9-41 of a P. lividusβ-thymosin. The…

Performance of EU-TIRADS in malignancy risk stratification of thyroid nodules. A meta-analysis

2020

Objective: Several thyroid imaging reporting and data systems (TIRADS) have been proposed to stratify the malignancy risk of thyroid nodule by ultrasound. The TIRADS by the European Thyroid Association, namely EU-TIRADS, was the last one to be published. Design: We conducted a meta-analysis to assess the prevalence of malignancy in each EU-TIRADS class and the performance of EU-TIRADS class 5 vs 2, 3 and 4 in detecting malignant lesions. Methods: Four databases were searched until December 2019. Original articles reporting the performance of EU-TIRADS and adopting histology as reference standard were included. The number of malignant nodules in each class and the number of nodules classifi…

Introduction to coronary imaging with 64-slice computed tomography

2005

The aim of this article is to illustrate the main technical improvements in the last generation of 64-row CT scanners and the possible applications in coronary angiography. In particular, we describe the new physical components (X-ray tube-detectors system) and the general scan and reconstruction parameters. We then define the scan protocols for coronary angiography with the new generation of 64-row CT scanners to enable radiologists to perform a CT study on the basis of the diagnostic possibilities.

Ensemble reconstruction constraints on the global carbon cycle sensitivity to climate

2010

The processes controlling the carbon flux and carbon storage of the atmosphere, ocean and terrestrial biosphere are temperature sensitive and are likely to provide a positive feedback leading to amplified anthropogenic warming. Owing to this feedback, at timescales ranging from interannual to the 20-100-kyr cycles of Earth's orbital variations, warming of the climate system causes a net release of CO(2) into the atmosphere; this in turn amplifies warming. But the magnitude of the climate sensitivity of the global carbon cycle (termed gamma), and thus of its positive feedback strength, is under debate, giving rise to large uncertainties in global warming projections. Here we quantify the med…

Current-Based Measurement Technique for High Sensitivity Detection of Resistive Bridges With External Balancing Through Control Voltages

2017

We present a novel approach based on differential measurements of dc currents with very high sensitivity suitable for the detection of very small variations of resistors in Wheatstone full-bridge configurations. External control voltages allow for the compensation of the bridge unbalancing avoiding the need of changing its elements so making the solution suitable for integrated sensor systems. The proposed current-based measurement technique has been implemented through three different circuits, in transimpedance configuration and without the use of any further amplification stage, employing only two active blocks that allow for a very high integration level. The main characteristics of the…

Erythropoietin and its lost receptor [8]

2007

Advanced Virgo Status

2015

Abstract The detection of a gravitational wave signal in September 2015 by LIGO interferometers, announced jointly by LIGO collaboration and Virgo collaboration in February 2016, opened a new era in Astrophysics and brought to the whole community a new way to look at - or “listen” to - the Universe. In this regard, the next big step was the joint observation with at least three detectors at the same time. This configuration provides a twofold benefit: it increases the signal-to-noise ratio of the events by means of triple coincidence and allows a narrower pinpointing of GW sources, and, in turn, the search for Electromagnetic counterparts to GW signals. Advanced Virgo (AdV) is the second ge…

Cytotoxic activity of secondary metabolites derived from Artemisia annua L. towards cancer cells in comparison to its designated active constituent a…

2010

Artemisia annua L. (sweet wormwood, qinhao) has traditionally been used in Chinese medicine. The isolation of artemisinin from Artemisia annua and its worldwide accepted application in malaria therapy is one of the showcase success stories of phytomedicine during the past decades. Artemisinin-type compounds are also active towards other protozoal or viral diseases as well as cancer cells in vitro and in vivo. Nowadays, Artemisia annua tea is used as a self-reliant treatment in developing countries. The unsupervised use of Artemisia annua tea has been criticized to foster the development of artemisinin resistance in malaria and cancer due to insufficient artemisinin amounts in the plant as c…

Development of Novel Benzodiazepine-Based Peptidomimetics as Inhibitors of Rhodesain from Trypanosoma brucei rhodesiense.

2020

Starting from the reversible rhodesain inhibitors 1 a-c, which have Ki values towards the target protease in the low-micromolar range, we have designed a series of peptidomimetics, 2 a-g, that contain a benzodiazepine scaffold as a β-turn mimetic; they are characterized by a specific peptide sequence for the inhibition of rhodesain. Considering that irreversible inhibition is strongly desirable in the case of a parasitic target, a vinyl ester moiety acting as Michael-acceptor was introduced as the warhead; this portion was functionalized in order to evaluate the size of corresponding enzyme pocket that could accommodate this substituent. With this investigation, we identified an irreversibl…

A roadmap towards improving managed security services from a privacy perspective

2014

Published version of an article in the journal: Ethics and Information Technology. Also available from the publisher at: http://dx.doi.org/10.1007/s10676-014-9348-3 This paper proposes a roadmap for how privacy leakages from outsourced managed security services using intrusion detection systems can be controlled. The paper first analyses the risk of leaking private or confidential information from signature-based intrusion detection systems. It then discusses how the situation can be improved by developing adequate privacy enforcement methods and privacy leakage metrics in order to control and reduce the leakage of private and confidential information over time. Such metrics should allow fo…