Search results for " sequence"
showing 10 items of 3643 documents
Activation of nitric oxide signaling by the rheumatoid arthritis shared epitope
2006
Objective. Susceptibility to rheumatoid arthritis (RA) is closely associated with HLA–DRB1 alleles encoding a shared epitope (SE) in positions 70–74 of the HLA–DR chain. The mechanistic basis for this association is unknown. Given the proposed pathogenic role of nitric oxide (NO) in RA, this study was undertaken to examine whether the SE can trigger NO signaling events. Methods. The intracellular levels of NO were measured with the fluorescent NO probe 4,5diaminofluorescein diacetate and by the 2,3diaminonaphthalene method. NO synthase activity was determined by measuring the rate of conversion of radioactive arginine to citrulline. Levels of cGMP were measured with a commercial enzyme-link…
Increasing chains and discrete reflection of cardinality
2013
Combining ideas from two of our previous papers, we refine Arhangel'skii Theorem by proving a cardinal inequality of which this is a special case: any increasing union of strongly discretely Lindelof spaces with countable free sequences and countable pseudocharacter has cardinality at most continuum. We then give a partial positive answer to a problem of Alan Dow on reflection of cardinality by closures of discrete sets.
Oxidative stress response of tumor cells: microarray-based comparison between artemisinins and anthracyclines
2004
The antimalarial artemisinins also reveal profound cytotoxic activity against tumor cells. Artemisinins harbor an endoperoxide bridge whose cleavage results in the generation of reactive oxygen species (ROS) and/or artemisinin carbon-centered free radicals. Established cancer drugs such as anthracyclines also form ROS and free radicals that are responsible for the cardiotoxicity of anthracyclines. In contrast, artemisinins do not reveal cardiotoxicity. In the present investigation, we compared the cytotoxic activities of different artemisinins (artemisinin, artesunate, arteether, artemether, artemisitene, dihydroartemisinylester stereoisomers) in 60 cell lines of the National Cancer Institu…
In silico and in vitro comparative analysis to select, validate and test SNPs for human identification.
2007
Abstract Background The recent advances in human genetics have recently provided new insights into phenotypic variation and genome variability. Current forensic DNA techniques involve the search for genetic similarities and differences between biological samples. Consequently the selection of ideal genomic biomarkers for human identification is crucial in order to ensure the highest stability and reproducibility of results. Results In the present study, we selected and validated 24 SNPs which are useful in human identification in 1,040 unrelated samples originating from three different populations (Italian, Benin Gulf and Mongolian). A Rigorous in silico selection of these markers provided …
EVIDENCE OF NON-THERMAL X-RAY EMISSION FROM HH 80
2013
Protostellar jets appear at all stages of star formation when the accretion process is still at work. Jets travel at velocities of hundreds of km s -1, creating strong shocks when interacting with the interstellar medium. Several cases of jets have been detected in X-rays, typically showing soft emission. For the first time, we report evidence of hard X-ray emission possibly related to non-thermal processes not explained by previous models of the post-shock emission predicted in the jet/ambient interaction scenario. HH 80 is located at the south head of the jet associated with the massive protostar IRAS 18162-2048. It shows soft and hard X-ray emission in regions that are spatially separate…
The Gaia-ESO survey: Metallicity of the chamaeleon i star-forming region
2014
Context. Recent metallicity determinations in young open clusters and star-forming regions suggest that the latter may be characterized by a slightly lower metallicity than the Sun and older clusters in the solar vicinity. However, these results are based on small statistics and inhomogeneous analyses. The Gaia-ESO Survey is observing and homogeneously analyzing large samples of stars in several young clusters and star-forming regions, hence allowing us to further investigate this issue. Aims. We present a new metallicity determination of the Chamaeleon I star-forming region, based on the products distributed in the first internal release of the Gaia-ESO Survey. Methods. 48 candidate member…
The Gaia-ESO Survey: Chromospheric emission, accretion properties, and rotation in gamma Velorum and Chamaeleon
2015
Aims: One of the goals of the Gaia-ESO Survey (GES), which is conducted with FLAMES at the VLT, is the census and the characterization of the low-mass members of very young clusters and associations. We conduct a comparative study of the main properties of the sources belonging to γ Velorum (γ Vel) and Chamaeleon I (Cha I) young associations, focusing on their rotation, chromospheric radiative losses, and accretion. Methods: We used the fundamental parameters (effective temperature, surface gravity, lithium abundance, and radial velocity) delivered by the GES consortium in the first internal data release to select the members of γ Vel and Cha I among the UVES and GIRAFFE spectroscopic obser…
XMM spectroscopy of TWA 5
2006
We present results of X-ray spectroscopy for TWA 5, a member of the young TW Hydrae association, observed with XMM-Newton. TWA 5 is a multiple system which shows H{alpha} emission, a signature typical of classical T Tauri stars, but no infrared excess. From this analysis of the RGS and EPIC spectra, we have derived the emission measure distribution vs. temperature of the X-ray emitting plasma, its abundances, and the electron density.
XMM-Newton survey of two Upper Scorpius regions
2007
We studied X-ray emission from young stars by analyzing the deep XMM-Newton observations of two regions of the Upper Scorpius association with an age of 5Myr. Based on near infrared and optical photometry we identified 22 Upper Scorpius photometric members among the 224 detected X-ray sources. We derived coronal properties of Upper Scorpius stars by performing X-ray spectral and timing analyses. The study of four strong and isolated stellar flares allowed us to derive the length of the flaring loops. Cone search capability for table J/A+A/459/199/tableb1 (Sources detected in the CTIO observations) Cone search capability for table J/A+A/459/199/tablec1 (Sources detected in the Danish 1.54m o…
Infrated photometry of NGC 1893
2008
The independence of the star formation processes with respect to the environmental conditions is controversial. In particular it is not clear whether star formation in the outer Galaxy, where the environmental conditions are, theoretically, less conducive, occurs in the same way as in the inner Galaxy. We investigate the population of NGC 1893, a young cluster (~3-4Myr) in the outer part of the Galaxy (galactic radius >11kpc) in order to explore the effects of environmental conditions on star forming regions. We present the infrared observations obtained with the IRAC camera on board of the Spitzer Space Telescope and analyze the color-color diagrams to establish the membership of stars wit…