Search results for " sequences"
showing 10 items of 243 documents
Conectores y secuencias didácticas en primer ciclo de educación primaria
2017
El punto de partida con el que iniciamos este artículo relaciona la enseñanza de elementos gramaticales, como los conectores, con la producción textual de escolares de segundo curso de Educación Primaria. En la investigación, que se lleva a cabo en aula, se elige como dispositivo una secuencia didáctica inspirada en el modelo de la escuela de Ginebra. La mediación elegida demuestra que resulta posible y eficaz introducir estos saberes gramaticales desde el inicio de la escolarización y que estos elementos ayudan, junto con el resto de la intervención, a mejorar los textos de los niños. Para ello aportamos el análisis de la producción inicial y final de un alumno y los resultados obtenidos d…
About Quotient Orders and Ordering Sequences
2017
Summary In preparation for the formalization in Mizar [4] of lotteries as given in [14], this article closes some gaps in the Mizar Mathematical Library (MML) regarding relational structures. The quotient order is introduced by the equivalence relation identifying two elements x, y of a preorder as equivalent if x ⩽ y and y ⩽ x. This concept is known (see e.g. chapter 5 of [19]) and was first introduced into the MML in [13] and that work is incorporated here. Furthermore given a set A, partition D of A and a finite-support function f : A → ℝ, a function Σ f : D → ℝ, Σ f (X)= ∑ x∈X f(x) can be defined as some kind of natural “restriction” from f to D. The first main result of this article ca…
Antibody Induction Directed against the Tumor-Associated MUC4 Glycoprotein
2015
Mucin glycoproteins are important diagnostic and therapeutic targets for cancer treatment. Although several strategies have been developed to explore anti-tumor vaccines based on MUC1 glycopeptides, only few studies have focused on vaccines directed against the tumor-associated MUC4 glycoprotein. MUC4 is an important tumor marker overexpressed in lung cancer and uniquely expressed in pancreatic ductual adenocarcinoma. The aberrant glycosylation of MUC4 in tumor cells results in an exposure of its peptide backbone and the formation of tumor-associated glycopeptide antigens. Due to the low immunogenicity of these endogenous structures, their conjugation with immune stimulating peptide or prot…
Mollusk antimicrobial peptides A review from activity-based evidences to computer-assisted sequences
2011
Antimicrobial peptides (AMPs) represent the most universal immune effectors. Molluscs constitute the second largest animal phylum, after Arthropods, in term of number of species. Only a negligible number has been investigated regarding AMPs. The choice of the species to be studied relied on their economical importance and availability. First studies on molluscan AMPs dated from 1996 and were based on biological activities of biochemical-purified fractions. Such approach released all the original structures we know, with biological activity sometimes different from one isoform to another. Then, molecular biology techniques were applied to molluscan AMPs starting in 1999. Complete screening o…
Direct detection of repetitive, whole chromosome paint and telomere DNA probes by immunogold electron microscopy
1993
Biotinylated repetitive, whole chromosome paint and telomere DNA probes were investigated at the electron microscope level after non-isotopic in situ hybridization and direct immunogold detection. The protocol described allowed the visualization of a biotinylated chromosome 1 specific satellite DNA probe in the light microscope without silver intensification. This sensitive method was exploited to analyse factors contributing to signal strength in immunogold chromosome painting. Furthermore, it allowed us to investigate the distribution of (TTAGGG)n telomere repeats in human metaphase chromosomes and interphase nuclei. Telomeric and internal (TTAGGG)n repeats were detected at high spatial r…
A low repeat length in oligodendrocyte chromatin
1985
Abstract: The behavior of oligodendrocyte chromatin after micrococcal nuclease digestion of nuclei was assayed in brains of rats of four different ages. During oligodendrocyte differentiation, a decreasing sensitivity of the chromatin to enzymatic attack was observed. On the other hand, the nucleosomal repeat length showed a slight tendency to increase during development. It is worth noting that even the highest values reported here for “oligodendrocyte’ chromatin repeat lengths are significantly lower than 200 base pairs, the value previously reported by others for “non‐astrocytic glia.” Copyright © 1985, Wiley Blackwell. All rights reserved
Application of multivariate t-pattern analysis in the study of social interactions in rats
2013
A basic tenet in the realm of modern behavioral sciences is that behavior consists of patterns in time. For this reason, investigations of behavior deal with sequences that are not easily perceivable by the unaided observer. This problem calls for improved means of detection, data handling and analysis. This review focuses on the analysis of the temporal structure of behavior carried out by means of a multivariate approach known as T-pattern analysis. Using this technique, recurring sequences of behavioral events, usually hard to detect, can be unveiled and carefully described. T-pattern analysis has been successfully applied in the study of various aspects of human or animal behavior such …
Recurring sequences of multimodal non-verbal and verbal communication during a human psycho-social stress test: A temporal pattern analysis
2020
Abstract Background The Trier Social Stress Test (TSST) is a widely used protocol to study human psycho-social stress responses. Quantitative reports of non-verbal behaviors have been carried out by means of the Ethological Coding System for Interviews (ECSI). However, no data have described whether and how non-verbal and verbal behaviors take part in the composition of multimodal sequences of communication during the test. Method Five non-verbal ECSI categories and four verbal behaviors related with communication were included in the Ethogram. A focal sampling was employed to ensure a high temporal resolution of the behavioral annotation. T-Pattern Analysis was employed to detect statistic…
Insights into the relationships of Palearctic and Nearctic lymnaeids (Mollusca : Gastropoda) by rDNA ITS-2 sequencing and phylogeny of stagnicoline i…
2003
Fascioliasis by Fasciola hepatica is the vector-borne disease presenting the widest latitudinal, longitudinal and altitudinal distribution known. F. hepatica shows a great adaptation power to new environmental conditions which is the consequence of its own capacities together with the adaptation and colonization abilities of its specific vector hosts, freshwater snails of the family Lymnaeidae. Several lymnaeid species only considered as secondary contributors to the liver fluke transmission have, however, played a very important role in the geographic expansion of this disease. Many of them belong to the so-called "stagnicoline" type group. Stagnicolines have, therefore, a very important a…
The Compass-like Locus, Exclusive to the Ambulacrarians, Encodes a Chromatin Insulator Binding Protein in the Sea Urchin Embryo
2013
Chromatin insulators are eukaryotic genome elements that upon binding of specific proteins display barrier and/or enhancer-blocking activity. Although several insulators have been described throughout various metazoans, much less is known about proteins that mediate their functions. This article deals with the identification and functional characterization in Paracentrotus lividus of COMPASS-like (CMPl), a novel echinoderm insulator binding protein. Phylogenetic analysis shows that the CMPl factor, encoded by the alternative spliced Cmp/Cmpl transcript, is the founder of a novel ambulacrarian-specific family of Homeodomain proteins containing the Compass domain. Specific association of CMPl…