Search results for " severity"

showing 10 items of 284 documents

Skimager for the objective erythema estimation in atopic dogs

2020

In this study, the severity of canine skin erythema was assessed objectively for the first time. Atopic dermatitis (AD) is a common canine inflammatory and pruritic skin disease associated with an allergic reaction to exogenous allergens. The monitoring of skin erythema over time with lesion severity scales like the CADESI-4 is an essential diagnostic and research tool, especially for clinical trials. Currently, the erythema assessment is subjective due to visual estimation. In our study, we calculated the erythema index (EI) in 14 atopic dogs based on the analysis of multispectral skin images taken with the Skimager device. The relationship between the EI and a visual erythema estimation w…

Skin erythemamedicine.medical_specialtyAllergic reactionErythema040301 veterinary sciencesErythema IndexOptical measurementsErythema severity01 natural sciences0403 veterinary scienceLesionMultispectral imagingDogsDisease severity scalesmedicineVisual estimationAtopic dermatitisintegumentary systembusiness.industry010401 analytical chemistry04 agricultural and veterinary sciencesAtopic dermatitismedicine.diseaseDermatology3. Good health0104 chemical sciencesCADESI-4medicine.symptombusinessSkin lesionSkimager
researchProduct

The magnesium global network (MaGNet) to promote research on magnesium in diseases focusing on covid-19

2021

When the current SARS-CoV-2 pandemic began in early 2020, the global magnesium researcher community came together and noted the striking similarities between COVID-19 risk factors and conditions associated with magnesium deficit state in humans, reasoning that magnesium deficiency could worsen the course of COVID-19 [1-4]. This prompted establishment of a worldwide collaborative network with regular virtual meetings to brainstorm the associations between magnesium and COVID-19. We hypothesize that magnesium deficiency, a common but mostly unrecognized state in modern global societies, could be an important component of the susceptibility to SARS-CoV-2 infection. Consequently, restoring the …

Societies ScientificAgingSupplementationComorbidityMetabolic DiseasesSettore MED/04 - PATOLOGIA GENERALENeoplasmsHypomagnesaemiaCardiovascular DiseaseHumansMagnesiumObesityDisease severityNutritionInflammationPreventionResearchCOVID-19ThrombosisScientificHypermagnesaemiaCongresses as TopicMetabolic DiseaseCardiovascular DiseasesImmune SystemICUThrombosiNeoplasmDisease Susceptibilityhypomagnesaemia hypermagnesaemia inflammation thrombosis prevention disease severity supplementation nutrition ICUSocietiesMagnesium DeficiencyDisease severity; Hypermagnesaemia; Hypomagnesaemia; ICU; Inflammation; Nutrition; Prevention; Supplementation; Thrombosis; Aging; COVID-19; Cardiovascular Diseases; Comorbidity; Congresses as Topic; Disease Susceptibility; Humans; Immune System; Inflammation; Magnesium; Magnesium Deficiency; Metabolic Diseases; Neoplasms; Obesity; Research; Societies ScientificHuman
researchProduct

The airway response to deep inspirations decreases with COPD severity and is associated with airway distensibility assessed by computed tomography.

2008

In patients with mild chronic obstructive pulmonary disease (COPD), the effect of deep inspirations (DIs) to reverse methacholine-induced bronchoconstriction is largely attenuated. In this study, we tested the hypothesis that the effectiveness of DI is reduced with increasing disease severity and that this is associated with a reduction in the ability of DI to distend the airways. Fifteen subjects [Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage I–II: n = 7; GOLD stage III–IV: n = 8] underwent methacholine bronchoprovocation in the absence of DI, followed by DI. The effectiveness of DI was assessed by their ability to improve inspiratory vital capacity and forced expira…

SpirometryHigh-resolution computed tomographyPhysiologyRespiratory SystemVital CapacityHyperinflationSettore MED/10 - Malattie Dell'Apparato RespiratorioSeverity of Illness IndexBronchial Provocation TestsBronchoconstrictor AgentsAirway-parenchyma interdependencePulmonary Disease Chronic ObstructiveBronchoprovocationPhysiology (medical)Forced Expiratory VolumeSeverity of illnessAdministration InhalationmedicineHumansHigh-resolution computed tomographyMethacholine ChlorideAgedAged 80 and overCOPDMethacholinemedicine.diagnostic_testbusiness.industryAirway-parenchyma interdependence; Bronchoprovocation; High-resolution computed tomography; Hyperinflation; Methacholine; Administration Inhalation; Aged; Aged 80 and over; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Elasticity; Forced Expiratory Volume; Humans; Methacholine Chloride; Middle Aged; Pulmonary Disease Chronic Obstructive; Respiratory System; Severity of Illness Index; Spirometry; Vital Capacity; Inhalation; Tomography Spiral Computed; Physiology; Physiology (medical)Respiratory diseaseArticlesrespiratory systemMiddle Agedmedicine.diseaseElasticityrespiratory tract diseasesBronchial Provocation TestInhalationSpirometryAnesthesiaBronchoconstrictor AgentBronchoconstrictionMethacholinemedicine.symptomBronchial HyperreactivityAirwaybusinessTomography Spiral ComputedHumanmedicine.drugJournal of applied physiology (Bethesda, Md. : 1985)
researchProduct

Development of a nomogram to estimate the quality of life in asthmatic children using the Childhood Asthma Control Test

2016

Background: Pediatric Asthma Quality of Life Questionnaire (PAQLQ) provides detailed information on QoL in asthmatic children, whereas Childhood Asthma Control Test (C-ACT) Questionnaire is the most validated instrument for asthma control. No study assessed the relationship between C-ACT and QoL in children by means of those instruments. The aim of this study was to determine whether a QoL estimation is possible using the C-ACT questionnaire in asthmatic children. Methods: Medical history, spirometry, C-ACT, and PAQLQ were assessed in 144 (60% male) outpatient asthmatic children from September 2011 to November 2014. A generalized linear model (GLM) for the prediction of PAQLQ was obtained t…

SpirometryMalePediatricsmedicine.medical_specialtyPediatric Asthma Quality of Life QuestionnaireImmunologyPediatricsSeverity of Illness IndexChildhood Asthma Control Testnomogram03 medical and health sciencesFEV1/FVC ratio0302 clinical medicineQuality of lifechildren030225 pediatricsSurveys and QuestionnairesSeverity of illnessMedicineImmunology and AllergyHumansMedical historyPreschoolChildAsthmaChildhood asthmaasthma; Childhood Asthma Control Test; children; control; nomogram; Pediatric Asthma Quality of Life Questionnaire; Asthma; Child; Child Preschool; Female; Humans; Italy; Male; Pediatrics; Prognosis; Reproducibility of Results; Severity of Illness Index; Spirometry; Surveys and Questionnaires; Nomograms; Quality of Life; Pediatrics Perinatology and Child Health; Immunology and Allergy; Immunologymedicine.diagnostic_testbusiness.industryReproducibility of ResultsNomogramPerinatology and Child Healthasthmamedicine.diseasePrognosisNomograms030228 respiratory systemItalySpirometryChild PreschoolPediatrics Perinatology and Child HealthQuality of LifeFemaleasthma; Childhood Asthma Control Test; children; control; nomogram; Pediatric Asthma Quality of Life Questionnaire; Pediatrics Perinatology and Child Health; Immunology and Allergy; Immunologybusinesscontrol
researchProduct

Effects of aclidinium on determinants of COPD severity: symptoms and quality of life

2016

Marco Contoli,1 Paolo Solidoro,2 Fabiano Di Marco,3,4 Nicola Scichilone,5 Angelo Corsico,6 Fulvio Braido,7 Pierachille Santus4,8 1Research Centre on Asthma and COPD, Department of Medical Sciences, University of Ferrara, Ferrara, Italy; 2Cardiovascular and Thoracic Department, Città della Salute, Turin, Italy; 3Department of Health Sciences, University of Milan, Milan, Italy; 4Respiratory Unit, San Paolo Hospital, Milan, Italy; 5Department of Internal Medicine, Section of Pulmonology (DIBIMIS), University of Palermo, Palermo, Italy; 6Department of Molecular Medicine, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; 7Allergy and Respiratory Diseases Clinic, DIMI, University of G…

Time FactorsReviewdaily symptomsAclidinium; COPD; Daily symptoms; LAMA; Quality of life; Pulmonary and Respiratory Medicine; Health Policy; Public Health Environmental and Occupational HealthSeverity of Illness IndexPulmonary Disease Chronic Obstructive0302 clinical medicineBronchodilatorMedicine030212 general & internal medicineLungCOPDHealth PolicyTropaneLAMAGeneral MedicineBronchodilator AgentsMuscarinic AntagonistTreatment OutcomeTolerabilityChronic inflammatory responsePublic HealthHumanPulmonary and Respiratory MedicineChronic Obstructivemedicine.medical_specialtyTime Factormedicine.drug_classBronchoconstrictionSocio-culturaleMuscarinic AntagonistsSettore MED/10 - Malattie Dell'Apparato RespiratorioPulmonary Disease03 medical and health sciencesAclidinium bromideaclidiniumAclidinium; COPD; Daily symptoms; LAMA; Quality of life; Bronchoconstriction; Bronchodilator Agents; Humans; Lung; Muscarinic Antagonists; Pulmonary Disease Chronic Obstructive; Recovery of Function; Severity of Illness Index; Time Factors; Treatment Outcome; Tropanes; Quality of LifeInternal medicineSeverity of illnessAnticholinergicCOPDHumansAdverse effectBronchodilator Agentlcsh:RC705-779business.industryEnvironmental and Occupational HealthDaily symptomPublic Health Environmental and Occupational Healthlcsh:Diseases of the respiratory systemRecovery of Functionmedicine.diseasequality of life030228 respiratory systemPhysical therapybusinessTropanesInternational Journal of Chronic Obstructive Pulmonary Disease
researchProduct

The association between appendicitis severity and patient age with appendiceal neoplasm histology—a population-based study

2022

Abstract Purpose Recent studies have reported alarming appendiceal tumor rates associated with complicated acute appendicitis, especially in patients presenting with a periappendicular abscess. However, the data on histology of appendiceal tumors among acute appendicitis patients is limited, especially in patient cohorts differentiating between uncomplicated and complicated acute appendicitis. We have previously reported the association of increased appendiceal tumor prevalence with complicated acute appendicitis in this population-based study. The objective of this secondary analysis was to evaluate the association of both appendicitis severity and patient age with appendiceal tumor histol…

UNCOMPLICATED ACUTE APPENDICITISAdultumpilisäketulehdusINTERVAL APPENDECTOMYANTIBIOTIC-THERAPYAdenocarcinoma3121 Internal medicineCONSERVATIVE TREATMENTNeuroendocrine tumorhistologiaMANAGEMENTAppendectomyHumansPseudomyxoma peritoneiINCREASED RISKMETAANALYSISMixed adeno-neuroendocrine carcinomapseudomyxoma peritoneiappendicitis severityappendiceal adenocarcinomaGastroenterologyneuroendokriiniset kasvaimetAppendiceal adenocarcinomaSERIESAppendicitisTUMORSAbscesskarsinoomatAppendiceal Neoplasms3121 General medicine internal medicine and other clinical medicineAcute Diseasemixed adeno-neuroendocrine carcinomaAppendicitis severityGoblet cell carcinomaneuroendocrine tumorgoblet cell carcinoma
researchProduct

Comparing indoor performances of a building equipped with four different roof configurations in 65 Italian sites

2020

Abstract—Despite the increasing concern of institutions and technical organizations toward the improvement of the building energy (and, therefore, environmental) efficiency, the main goal of technicians should be also devoted toward the levels of internal thermal comfort that buildings are able to realize. As that, the relationships between energy performances and comfort conditions provided by the enclosures are of paramount importance in guiding designers in their work. In this paper, the influence of diverse roof construction typologies on energy and indoor performance of buildings has been investigated, in different Italian sites during heating and cooling seasons. In addition, it must …

Value (ethics)Architectural engineeringComputer science020209 energyGreen roofTechnical standardThermal comfort02 engineering and technologyThermal comfort010501 environmental sciences01 natural sciencesWork (electrical)Cool roofGreen roof0202 electrical engineering electronic engineering information engineeringReflective surfacesClimatic Severity Index.Roof0105 earth and related environmental sciencesEfficient energy use2020 IEEE 20th Mediterranean Electrotechnical Conference ( MELECON)
researchProduct

Differential Effects of Biologics on Psoriasis-Related Vascular Inflammation and Risk of Thrombosis

2020

Programa Estatal de I+D+i Orientada a los Retos de la Sociedad from Ministerio de Ciencia, Innovación y Universidades and European Regional Development Fund (Spain) [RTI2018-094436-B-I00]; Ministerio de Sanidad y Consumo CIBERehd (Spain) [CB06/04/0071]; Generalitat Valenciana (Spain) [PROMETEO/2018/141]; Proyectos Grupos Emergentes [GV/2019/043]; and Universidad Europea (Spain) (2018/UEM32 and 2019/UEM29]. 8.551 JCR (2020) Q1, 4/69 Dermatology 1.951 SJR (2020) Q1, 54/438 Biochemistry No data IDR 2020 UEV

Vasculitis0301 basic medicinemedicine.medical_specialtyEnfermedad cardiovascularImiquimodCell CommunicationDermatologyBiochemistryMiceTrombosis03 medical and health sciences0302 clinical medicinePsoriasis Area and Severity IndexPsoriasisProductos biológicosLeukocytesmedicineAnimalsHumansPsoriasisMolecular BiologyBody surface areaBiological ProductsImiquimodTumor Necrosis Factor-alphabusiness.industryEndothelial CellsThrombosisCell BiologyDermatology Life Quality Indexmedicine.diseaseDermatologyThrombosis030104 developmental biology030220 oncology & carcinogenesisMethotrexatebusinessEnfermedad de la pielMacemedicine.drugJournal of Investigative Dermatology
researchProduct

Kawasaki disease in Sicily: clinical description and markers of disease severity

2016

Background: Kawasaki disease (KD) is an acute systemic vasculitis of small and middle size arteries; 15-25 % of untreated patients and 5 % of patients treated with intravenous immunoglobulin (IVIG) develop coronary artery lesions (CAL). Many studies tried to find the most effective treatment in the management of resistant KD and to select the risk factors for CAL. Our data are assessed on children from west Sicily, characterized by a genetic heterogeneity. Methods: We studied the clinical data of 70 KD Sicilian children (36 males: 51 %; 34 females: 49 %), analysed retrospectively, including: demographic and laboratory parameters; echocardiographic findings at diagnosis, at 2, 6 and 8 weeks,…

VasculitisMaleVasculitimedicine.medical_specialtyCardiovascular Disease; Kawasaki Disease; Small Vessel Vasculitis; Vasculitis030204 cardiovascular system & hematologyMucocutaneous Lymph Node SyndromeSeverity of Illness IndexSmall Vessel Vasculitis03 medical and health sciencesSettore MED/38 - Pediatria Generale E Specialistica0302 clinical medicineDisease severity030225 pediatricshemic and lymphatic diseasesCardiovascular DiseaseMedicineEffective treatmentHumansKawasaki DiseaseSicilyCardiovascular Disease; Kawasaki Disease; Small Vessel Vasculitis; Vasculitis; Pediatrics Perinatology and Child HealthRetrospective Studiesbiologybusiness.industryGenetic heterogeneityResearchmedicine.diseaseDermatologySmall Vessel Vasculitimedicine.anatomical_structureEchocardiographyChild PreschoolPediatrics Perinatology and Child HealthImmunologybiology.proteinKawasaki diseaseFemaleAntibodybusinessVasculitisBiomarkersSystemic vasculitisArteryItalian Journal of Pediatrics
researchProduct

Vitamin A deficiency is associated with disease severity in patients with liver cirrhosis

2020

Vitamin A deficiencymedicine.medical_specialtyCirrhosisDisease severitybusiness.industryInternal medicinemedicineIn patientmedicine.diseasebusinessGastroenterologyZeitschrift für Gastroenterologie
researchProduct