Search results for " shock"
showing 10 items of 691 documents
Extracorporeal Shock Wave Lithotripsy of Ureteral Stones: Clinical Experience and Experimental Findings
1986
AbstractESWL of impacted ureteral or caliceal stones is not as successful as expected. To study this problem a model for extracorporeal shock wave lithotripsy of ureteral stones has been designed. After initial fragmentation of the outer shell of impacted stones during the first series of shock wave application those fragments are kept in place by external mucosal contact, creating a lot of new interfaces.Absorption or reflection of shock wave energy within this fragmented shell seems to be responsible for the poor success rate in these cases. In regard to our experimental and clinical results we advise pushing ureteral stones back into the renal collecting system by means of a ureteral cat…
High-order regularization in lattice-Boltzmann equations
2017
A lattice-Boltzmann equation (LBE) is the discrete counterpart of a continuous kinetic model. It can be derived using a Hermite polynomial expansion for the velocity distribution function. Since LBEs are characterized by discrete, finite representations of the microscopic velocity space, the expansion must be truncated and the appropriate order of truncation depends on the hydrodynamic problem under investigation. Here we consider a particular truncation where the non-equilibrium distribution is expanded on a par with the equilibrium distribution, except that the diffusive parts of high-order nonequilibrium moments are filtered, i.e., only the corresponding advective parts are retained afte…
Post-adiabatic supernova remnants in an interstellar magnetic field: oblique shocks and non-uniform environment
2018
Monthly notices of the Royal Astronomical Society 479(3), 4253 - 4270 (2018). doi:10.1093/mnras/sty1750
MODELING SNR CASSIOPEIA A from the SUPERNOVA EXPLOSION to ITS CURRENT AGE: The ROLE of POST-EXPLOSION ANISOTROPIES of EJECTA
2016
The remnants of core-collapse supernovae (SNe) have complex morphologies that may reflect asymmetries and structures developed during the progenitor SN explosion. Here we investigate how the morphology of the SNR Cassiopeia A (Cas A) reflects the characteristics of the progenitor SN with the aim to derive the energies and masses of the post-explosion anisotropies responsible for the observed spatial distribution of Fe and Si/S. We model the evolution of Cas A from the immediate aftermath of the progenitor SN to the three-dimensional interaction of the remnant with the surrounding medium. The post-explosion structure of the ejecta is described by small-scale clumping of material and larger-s…
Impact of self-steepening on incoherent dispersive spectral shocks and collapse-like spectral singularities
2014
International audience; Incoherent dispersive shock waves and collapselike singularities have been recently predicted to occur in the spectral evolution of an incoherent optical wave that propagates in a noninstantaneous nonlinear medium. Here we extend this work by considering the generalized nonlinear Schrödinger equation. We show that self-steepening significantly affects these incoherent spectral singularities: (i) It leads to a delay in the development of incoherent dispersive shocks, and (ii) it arrests the incoherent collapse singularity. Furthermore, we show that the spectral collapselike behavior can be exploited to achieve a significant enhancement (by two orders of magnitudes) of…
Supernova 1987A: a Template to Link Supernovae to their Remnants
2015
The emission of supernova remnants reflects the properties of both the progenitor supernovae and the surrounding environment. The complex morphology of the remnants, however, hampers the disentanglement of the two contributions. Here we aim at identifying the imprint of SN 1987A on the X-ray emission of its remnant and at constraining the structure of the environment surrounding the supernova. We performed high-resolution hydrodynamic simulations describing SN 1987A soon after the core-collapse and the following three-dimensional expansion of its remnant between days 1 and 15000 after the supernova. We demonstrated that the physical model reproducing the main observables of SN 1987A during …
Functional characterisation of the first HSP110 inhibitors.
2023
Heat shock proteins are molecular chaperones highly expressed in haematological malignancies. My laboratory has shown that the heat shock protein HSP110 is a new and important therapeutic target In colorectal cancer and in non-Hodgkin's lymphoma. As there were no existing inhibitors of HSP110, a screening strategy of a chemical library was carried out and allowed the identification of two molecules capable of specifically inhibiting the chaperone activity of HSP110. My thesis objective was to characterise and functionally validate these newly identified molecules in diffuse large cell B lymphomas. I have shown that one of these molecules limits the interaction of HSP110 with the SYK signall…
Response of yeast cells to high glucose involves molecular and physiological differences when compared to other osmostress conditions.
2015
Yeast cells can be affected by several causes of osmotic stress, such as high salt, sorbitol or glucose concentrations. The last condition is particularly interesting during natural processes where this microorganism participates. Response to osmostress requires the HOG (High Osmolarity Glycerol) pathway and several transcription factors, including Hot1, which plays a key role in high glucose concentrations. In this work, we describe how the yeast response to osmotic stress shows differences in accordance with the stress agent responsible for it. Compared with other conditions, under high glucose stress, delocalization of MAPK (Mitogen-Activated Protein Kinase) Hog1 is slower, induction of …
Alien at home: Adjustment strategies of students returning from a six-months over-sea's educational programme
2015
Abstract This paper assesses German students’ adjustment strategies after a six months expeditionary learning programme on high seas with intercultural encounters in Cuba and Costa Rica. A postal survey (N = 128, global response quote rg = .44) has been conducted with students having returned from four separate learning expeditions from 2008 to 2012. The students reports were coded in five categories, i.e. (1) reintegration narratives (RN), (2) perception of schooling (PoS), (3) self-perception (SP), (4) perceived programme effects (PPE), and (5) social context (SC), which were also quantified on a 5-point Likert-scale. By means of principal components analyses (PCA) and polynominal interpo…
Effect of sublethal concentrations of copper sulphate on seabreamSparus auratafingerlings
2007
The gilthead seabream is the most important Mediterranean aquacultured fish species. The main objective of this study was to investigate whether copper sulphate bath treatments used routinely in aquaculture have effects on important physiological functions of early life stages of the gilthead seabream (Sparus aurata). Fingerlings (80-90 days, 0.27 ± 0.06 g) were exposed to copper sulphate baths at 0, 0.25, 0.5 and 1.5 mg L −1 during 24 h. Effects on the central nervous function were evaluated analysing brain acetylcholinesterase activity (AChE). Oxidative stress was assessed by the quantification of lipid peroxidation (LP). Heat shock proteins (HSP70) were used as a general response to chem…