Search results for " sign"

Wiener-Granger Causality in Network Physiology with Applications to Cardiovascular Control and Neuroscience

2016

Since the operative definition given by C. W. J. Granger of an idea expressed by N. Wiener, the Wiener–Granger causality (WGC) has been one of the most relevant concepts exploited by modern time series analysis. Indeed, in networks formed by multiple components, working according to the notion of segregation and interacting with each other according to the principle of integration, inferring causality has opened a window on the effective connectivity of the network and has linked experimental evidences to functions and mechanisms. This tutorial reviews predictability improvement, information-based and frequency domain methods for inferring WGC among physiological processes from multivariate…

Solutions with sign information for nonlinear Robin problems with no growth restriction on reaction

2019

We consider a parametric nonlinear Robin problem driven by a nonhomogeneous differential operator. The reaction is a Carathéodory function which is only locally defined (that is, the hypotheses concern only its behaviour near zero). The conditions on the reaction are minimal. Using variational tools together with truncation, perturbation and comparison techniques and critical groups, we show that for all small values of the parameter λ > 0, the problem has at least three nontrivial smooth solutions, two of constant sign and the third nodal.

Acute neuromuscular and hormonal responses and long-term adaptations to hypertrophic resistance training : with special reference to constant versus …

2012

Investigation of Coating Impact on OFDR Optical Remote Fiber-Based Sensors Performances for Their Integration in High Temperature and Radiation Envir…

2016

The response of optical frequency-domain reflectometry-based temperature sensors is here investigated in harsh environments (high temperature, high radiation dose) focusing the attention on the impact of the fiber coating on the sensor performances in such conditions. Our results demonstrate that the various coating types evolve differently under thermal treatment and/or radiations, resulting in a small (<5%) change in the temperature coefficient of the sensor. The identified procedure, consisting of a prethermal treatment of the fiber at its maximum coating operating temperature, is here verified up to 150 °C for higherature acrylate and up to 300 °C for polyamide coating. This method allo…

Kontrabanda organizētā grupā

2016

Bakalaura darba tēma ir “Kontrabanda organizētā grupā”. Darba mērķis ir pētīt kontrabandas noziedzīgus nodarījumus, kas pastrādāti organizētā grupā Krimināllikuma 190.panta izpratnē (ar grozījumiem, kas stājās spēkā ar 2015.gada 3.decembri). Aplūkot kontrabandas rašanās vēsturi, sākot no 1903.gada līdz mūsdienām. Izpētīt tās attīstību un problemātiku, mainoties politiskai un ekonomiskai situācijai. Autore veiks kontrabandas pamatsastāva un kvalificējošo pazīmju analīzi. Mēģinās izprast kontrabandas krimināltiesisko atbildību un tās atšķirību no administratīvā pārkāpuma. Darbā tiks veikts kontrabandas jēdziena salīdzinājums ar ārvalstu krimināltiesībām.

Increased dosage of Ink4/Arf protects against glucose intolerance and insulin resistance associated with aging

2013

Recent genome-wide association studies have linked type-2 diabetes mellitus to a genomic region in chromosome 9p21 near the Ink4/Arf locus, which encodes tumor suppressors that are up-regulated in a variety of mammalian organs during aging. However, it is unclear whether the susceptibility to type-2 diabetes is associated with altered expression of the Ink4/Arf locus. In the present study, we investigated the role of Ink4/Arf in age-dependent alterations of insulin and glucose homeostasis using Super-Ink4/Arf mice which bear an extra copy of the entire Ink4/Arf locus. We find that, in contrast to age-matched wild-type controls, Super-Ink4/Arf mice do not develop glucose intolerance with agi…

Endoderm development requires centrioles to restrain p53-mediated apoptosis in the absence of ERK activity

2021

Centrioles comprise the heart of centrosomes, microtubule-organizing centers. To study the function of centrioles in lung and gut development, we genetically disrupted centrioles throughout the mouse endoderm. Surprisingly, removing centrioles from the endoderm did not disrupt intestinal growth or development but blocked lung branching. In the lung, acentriolar SOX2-expressing airway epithelial cells apoptosed. Loss of centrioles activated p53, and removing p53 restored survival of SOX2-expressing cells, lung branching, and mouse viability. To investigate how endodermal p53 activation specifically killed acentriolar SOX2-expressing cells, we assessed ERK, a prosurvival cue. ERK was active t…

Digital control circuitry for the p53 dynamics in cancer cell and apoptosis

2010

Abstract Experimental work and theoretical models deduce a “digital” response of the p53 transcription factor when genomic integrity is damaged. The mutual influence of p53 and its antagonist, the Mdm2 oncogene, is closed in a feedback. This paper proposes an aerospace-based architecture for translating the p53/Mdm2/DNA damage network into a digital circuitry in which the optimal control theory is applied for obtaining the requested dynamic evolutions of some considered cell species for repairing a DNA damage. The purpose of this paper is to demonstrate the usefulness of such digital circuitry design to detect and predict the cell species dynamics for shedding light on their inner and mutua…

Giving patients secure " google-like " access to their medical record

2008

International audience; The main problem for the patient who wants to have access to all of the information about his health is that this information is very often spread over many medical records. Therefore, it would be convenient for the patient, after being identified and authenticated, to use a kind of specific medical search engine as one part of the solution to this main problem. The principal objective is for the patient to have access to his or her medical information at anytime and wherever it has been stored. This proposal for secure "Google Like" access requires the addition of different conditions: very strict identity checks using cryptographic techniques such as those planned …

Skuteczność doświadczenia liturgii

2020

Artykuł podejmuje zagadnienie skutecznego oddziaływania liturgii na jej uczestników i w ogóle stykających się z nią, uwypuklając jej ewangelizacyjne i formacyjne skutki. W szczególny sposób uwzględniono w nim znaczenie piękna liturgicznych celebracji, jak również kwestie związane z tzw. participatio actuosa. Zasadniczą bazę źródłową artykułu stanowią publikacje takich wybitnych teologów, jak: J. Ratzinger, R. Guardini oraz J.A. Jungmann. Analiza ich refleksji zachęca do nowego odkrywania istotnej roli liturgii, zwłaszcza liturgii niedzielnej Mszy św. − jako najważniejszego wydarzenia w religijnym życiu chrześcijanina na przestrzeni tygodnia, a także do ukazywania wartości doświadczenia litu…