Search results for " signal"
showing 6 items of 2056 documents
Nuclear localization but not PML protein is required for incorporation of the papillomavirus minor capsid protein L2 into virus-like particles.
2004
ABSTRACT Recent reports suggest that nuclear domain(s) 10 (ND10) is the site of papillomavirus morphogenesis. The viral genome replicates in or close to ND10. In addition, the minor capsid protein, L2, accumulates in these subnuclear structures and recruits the major capsid protein, L1. We have now used cell lines deficient for promyelocytic leukemia (PML) protein, the main structural component of ND10, to study the role of this nuclear protein for L2 incorporation into virus-like particles (VLPs). L2 expressed in PML protein knockout (PML −/− ) cells accumulated in nuclear dots, which resemble L2 aggregates forming at ND10 in PML protein-containing cells. These L2 assemblies also attracted…
PTC124-mediated translational readthrough of a nonsense mutation causing Usher syndrome type 1C.
2011
We investigated the therapeutic potential of the premature termination codon (PTC) readthrough-inducing drug PTC124 in treating the retinal phenotype of Usher syndrome, caused by a nonsense mutation in the USH1C gene. Applications in cell culture, organotypic retina cultures, and mice in vivo revealed significant readthrough and the recovery of protein function. In comparison with other readthrough drugs, namely the clinically approved readthrough-inducing aminoglycoside gentamicin, PTC124 exhibits significant better retinal biocompatibility. Its high readthrough efficiency in combination with excellent biocompatibility makes PTC124 a promising therapeutic agent for PTCs in USH1C, as well a…
Sing and Measure: Sound as Voice as Quanta
2022
The universal concept of a “music of the spheres” traverses the history of philosophy, science and art, from Pythagoras to Kepler and beyond. In modern times, a sphere in three dimensions—the Bloch sphere—is used to illustrate the state of a qubit, the basic unit of quantum information. On the same spherical surface, the fundamental components of voice production can be located, so that any utterance can be seen as the evolution of a unit two-dimensional vector having complex coefficients. Indeed, any sound can be analyzed and decomposed into overlapping sinusoidal components, broadband noises, and impulsive transients, which in turn can be associated to fundamental means of vocal sound pro…
Multimodal Aposematic Signals and Their Emerging Role in Mate Attraction
2018
Chemically defended animals often display conspicuous color patterns that predators learn to associate with their unprofitability and subsequently avoid. Such animals (i.e., aposematic), deter predators by stimulating their visual and chemical sensory channels. Hence, aposematism is considered to be “multimodal.” The evolution of warning signals (and to a lesser degree their accompanying chemical defenses) is fundamentally linked to natural selection by predators. Lately, however, increasing evidence also points to a role of sexual selection shaping warning signal evolution. One of the species in which this has been shown is the wood tiger moth, Arctia plantaginis, which we here put forward…
System wczesnego ostrzegania w zarządzaniu projektami jako narzędzie wspomagania osiągania sukcesu projektu
2020
Celem artykułu jest zaprezentowanie istoty systemów wczesnego ostrzegania w zarządzaniu projektami w kontekście osiągania celów projektów. Potrzeba stosowania narzędzi wczesnego ostrzegania w zarządzaniu projektami ma uzasadnienie przede wszystkim w fakcie, że z reguły (pomijając zdarzenia nadzwyczajne) przedsiębiorstwa wykazują objawy sytuacji kryzysowych w realizacji podejmowanych projektów na długo przedtem zanim dojdzie do niepowodzenia projektu. Wczesne zidentyfikowanie sygnałów zbliżającego się kryzysu powinno być zatem jednym z podstawowych zadań w zarządzaniu projektami. W artykule omówiono rolę systemu wczesnego ostrzegania oraz jego funkcje. Wskazano na zastosowania systemów wczes…
XENON1T Dark Matter Data Analysis: Signal Reconstruction, Calibration and Event Selection
2019
The XENON1T experiment at the Laboratori Nazionali del Gran Sasso is the most sensitive direct detection experiment for dark matter in the form of weakly interacting particles (WIMPs) with masses above $6\,$GeV/$c^2$ scattering off nuclei. The detector employs a dual-phase time projection chamber with 2.0 metric tons of liquid xenon in the target. A one metric $\mathrm{ton}\times\mathrm{year}$ exposure of science data was collected between October 2016 and February 2018. This article reports on the performance of the detector during this period and describes details of the data analysis that led to the most stringent exclusion limits on various WIMP-nucleon interaction models to date. In pa…