Search results for " solution"
showing 10 items of 3084 documents
Physicochemical compatibility of mixtures of dornase alfa and tobramycin containing nebulizer solutions
2008
Patients suffering from cystic fibrosis (CF) often need to inhale multiple doses of different nebulizable drugs per day. Patients attempt to shorten the time consuming administration procedure by mixing drug solutions/suspensions for simultaneous inhalation. The objective of this experimental study was to determine whether mixtures of the nebulizer solution dornase alfa (Pulmozyme) with tobramycin nebulizer solutions (TOBI and GERNEBCIN 80 mg) are physico-chemically compatible. Drug combinations were prepared by mixing the content of one respule Pulmozyme with either one respule TOBI or one ampoule GERNEBCIN 80 mg. Test solutions were stored at room temperature and exposed to light. Dornase…
A New Technical Approach For Retrograde Administration of Cardioplegic Solutions
1989
Myocardial protection via the coronary sinus is now currently used by several groups. Although it has generally provided satisfactory results, some of its problems are still not completely resolved. We present a new technique of cardioplegia delivery through the coronary sinus with a Pezzer catheter inserted into it and secured in place by a purse string suture. We believe that this method is safer and more reliable than others.
Physicochemical compatibility and stability of nebulizable drug admixtures containing Dornase alfa and tobramycin.
2012
The objective of this in-vitro study was to determine whether admixtures of the inhalation solutions Pulmozyme(®) (Dornase alfa) and either Bramitob(®) or Tobi(®) (both containing Tobramycin) are physicochemically compatible and to analyze the aerodynamic parameters of these admixtures. After mixing, test solutions were stored at room temperature and under ambient light conditions over a period of 24 h. Tobramycin concentrations were determined by using a fluorescence immunoassay. Stability of dornase alfa was determined by size-exclusion high performance liquid chromatography, ultraviolet spectroscopy, sodium dodecyl sulfate polyacrylamide gel electrophoresis and tentacle strong cation-exc…
Induction of stress proteins in human endothelial cells by heavy metal ions and heat shock.
1999
In the present study, we compared the induction of heat shock proteins (HSPs) by heat and heavy metal ions in three different endothelial cell types, namely, human umbilical vein endothelial cells, human pulmonary microvascular endothelial cells, and the cell line EA.hy 926. Our results show that especially Zn2+and Cd2+are inducers of 70-kDa (HSP70), 60-kDa (HSP60), 32-kDa (HSP32), and 27-kDa (HSP27) HSPs. The strength of inducibility is specific for each HSP. Ni2+and Co2+only show an inducible effect at very high concentrations, that is, in the clearly cytotoxic range. Furthermore, we investigated the time course of HSP expression and the involvement of heat shock factor-1. Our study demon…
Which factors affect the choice of the inhaler in chronic obstructive respiratory diseases?
2015
Inhalation is the preferred route of drug administration in chronic respiratory diseases because it optimises delivery of the active compounds to the targeted site and minimises side effects from systemic distribution. The choice of a device should be made after careful evaluation of the patient's clinical condition (degree of airway obstruction, comorbidities), as well as their ability to coordinate the inhalation manoeuvre and to generate sufficient inspiratory flow. These patient factors must be aligned with the specific advantages and limitations of each inhaler when making this important choice. Finally, adherence to treatment is not the responsibility of the patient alone, but should …
Parameter dependence for the positive solutions of nonlinear, nonhomogeneous Robin problems
2020
We consider a parametric nonlinear Robin problem driven by a nonlinear nonhomogeneous differential operator plus an indefinite potential. The reaction term is $$(p-1)$$-superlinear but need not satisfy the usual Ambrosetti–Rabinowitz condition. We look for positive solutions and prove a bifurcation-type result for the set of positive solutions as the parameter $$\lambda >0$$ varies. Also we prove the existence of a minimal positive solution $$u_\lambda ^*$$ and determine the monotonicity and continuity properties of the map $$\lambda \rightarrow u_\lambda ^*$$.
A note on homoclinic solutions of (p,q)-Laplacian difference equations
2019
We prove the existence of at least two positive homoclinic solutions for a discrete boundary value problem of equations driven by the (p,q) -Laplace operator. The properties of the nonlinearity ensure that the energy functional, corresponding to the problem, satisfies a mountain pass geometry and a Palais–Smale compactness condition.
Symmetry for positive critical points of Caffarelli–Kohn–Nirenberg inequalities
2022
Abstract We consider positive critical points of Caffarelli–Kohn–Nirenberg inequalities and prove a Liouville type result which allows us to give a complete classification of the solutions in a certain range of parameters, providing a symmetry result for positive solutions. The governing operator is a weighted p -Laplace operator, which we consider for a general p ∈ ( 1 , d ) . For p = 2 , the symmetry breaking region for extremals of Caffarelli–Kohn–Nirenberg inequalities was completely characterized in Dolbeault et al. (2016). Our results extend this result to a general p and are optimal in some cases.
Nonlinear vector Duffing inclusions with no growth restriction on the orientor field
2019
We consider nonlinear multivalued Dirichlet Duffing systems. We do not impose any growth condition on the multivalued perturbation. Using tools from the theory of nonlinear operators of monotone type, we prove existence theorems for the convex and the nonconvex problems. Also we show the existence of extremal trajectories and show that such solutions are $C_0^1(T,\mathbb{R}^N)$-dense in the solution set of the convex problem (strong relaxation theorem).
Weak solution for Neumann (p,q)-Laplacian problem on Riemannian manifold
2019
We prove the existence of a nontrivial solution for a nonlinear (p, q)-Laplacian problem with Neumann boundary condition, on a non compact Riemannian manifold. The idea is to reduce the problem in variational form, which means to consider the critical points of the corresponding Euler-Lagrange functional in an Orlicz-Sobolev space. (C) 2019 Elsevier Inc. All rights reserved.