Search results for " sor"
showing 10 items of 408 documents
L’ordre des noms et l’auctorialité de Sorel selon La Bibliothèque Française
2015
International audience; ...
In vitro differentiation of E-N-CAM expressing rat neural precursor cells isolated by FACS during prenatal development
1994
Most fetal rat brain cells expressing the embryonal, highly sialylated form of the cell adhesion molecule N-CAM (E-N-CAM) are precursor cells, as judged from the absence of marker molecules specific for mature neural cell types. However, the detection of E-N-CAM+ cells in frozen sections does not provide information on the lineage-specific differentiation of these cells during development. To investigate their differentiation behaviour in vitro, E-N-CAM+ cells were isolated at different times of brain development by fluorescence-activated cell sorting (FACS), using a monoclonal antibody (Mab RB21-7) which specifically recognizes polysialic acid (PSA) residues on E-N-CAM. Double-immunofluore…
Discovery of a New Class of Sortase A Transpeptidase Inhibitors to Tackle Gram-positive Pathogens: 2-Phenylhydrazonoalkanoic Acid Derivatives
2015
There is an urgent need of anti-virulence agents effective in the prevention or eradication of biofilms that are intrinsically resistant to conventional antibiotics. If we consider that the first step of staphylococcal pathogenesis and of biofilm formation is the bacterial adhesion, promoted by the surface exposed proteins at the cell wall, we believe that new anti-virulence agents could be developed by using as a target the Sortase A (SrtA), the enzyme responsible of linking surface exposed proteins to peptidoglycan. Therefore, SrtA inhibitors could act as anti-adhesion agents useful to prevent Gram positive virulence mechanisms as well as a virulence mechanism based on biofilm formation. …
Antimona(V) sorbcijas izpēte uz modificētiem biomateriālu sorbentiem
2014
Antimona(V) savienojumu sorbcijai veikta bioloģiskas izcelsmes sorbentu modificēsana ar dzelzs savienojumiem. Izmantojot dažādas fizikālķīmiskās metodes, noteikti sorbentus raksturojosie parametri. Veikti antimona sorbcijas eksperimenti, izmantojot modificētus – kūdras, skaidu, sūnu, salmu, niedru un smilsu sorbentus, noteikta iegūto rezultātu atbilstība gan Lengmīra, gan Freindliha teorētiskajiem sorbcijas modeļiem. Pētīta sorbcijas atkarība no temperatūras un veikti termodinamisko parametru aprēķini. Konstatēts, ka labākais antimona(V) savienojumu sorbents ir modificēta kūdra, sorbcijas process ir spontāns un endotermisks.
Gradienti di reciprocità
2007
Letteratura e immagini si osservano attraverso sguardi reciproci che si dispongono secondo una scala di relazioni: sopravvivenze, descrizioni, rappresentazioni. Il saggio pone le basi teoriche per le diverse relazioni tra le due arti sorelle.
Lo sguardo reciproco. Letteratura e immagini tra Settecento e Novecento
2007
Atezolizumab plus bevacizumab versus lenvatinib or sorafenib in non-viral unresectable hepatocellular carcinoma: an international propensity score ma…
2022
Background: A growing body of evidence suggests that non-viral hepatocellular carcinoma (HCC) might benefit less from immunotherapy. Materials and methods: We carried out a retrospective analysis of prospectively collected data from consecutive patients with non-viral advanced HCC, treated with atezolizumab plus bevacizumab, lenvatinib, or sorafenib, in 36 centers in 4 countries (Italy, Japan, Republic of Korea, and UK). The primary endpoint was overall survival (OS) with atezolizumab plus bevacizumab versus lenvatinib. Secondary endpoints were progression-free survival (PFS) with atezolizumab plus bevacizumab versus lenvatinib, and OS and PFS with atezolizumab plus bevacizumab versus soraf…
I Segni Raccontano: La lingua Italiana dei Segni tra esperienze, strumenti e metodologie
2009
La LIS (Lingua dei Segni Italiana) è una delle tante lingue dei segni diffuse nel mondo su cui esiste ormai una considerevole letteratura, ma che stenta a trovare riconoscimenti e spazi, non solo giuridici, ma nello stesso immaginario collettivo. Questo sia in virtù dell'inferiorità di status che il gesto ha assunto rispetto alla parola nel sistema concettuale occidentale, sia perché non viene "trattata" da lingua ma come oggetto rispetto al quale assumere posizioni pro o contro. Dopo I segni parlano (Angeli, 2008), incentrato su questioni di interesse linguistico, un ulteriore volume dal titolo emblematico, I segni raccontano, dimostra come la LIS non sia solo la lingua "delle persone sord…
Novel Sortase A (SrtA) inhibitors interfere with the formation of staphylococcal biofilms
2013
Staphylococcus aureus, due to its wide arsenal of virulence factors, is a very versatile pathogen responsible for a wide variety of infectious diseases. The virulence factors include the cell-wall associated proteins that have a direct role in the first stage of pathogenesis. The Sortase A (SrtA) transpeptidase is responsible for covalent anchoring to the cell wall of various surface proteins and it is considered a good target to design new antivirulence agents. In this study, we report the identification of an inhibitor of SrtA afforded from the random screening of a small molecular library of around 150 synthetic compounds, through a high throughput assay by using the standard Dabcyl-QALP…
ANTI-STAPHYLOCOCCAL BIOFILM ACTIVITY OF NOVEL SORTASE A (SRTA) INHIBITORS
2013
Pathogenic staphylococci have an extraordinary ability to form biofilms. This characteristic is likely the most important virulence factor of staphylococci in the development of the chronic form of infectious diseases and in biomaterial associated infections (BAI). Staphylococcal biofilms are particularly dangerous because they are more resistant to host immune defence system and have a significantly increased tolerance to conventional antibiotics. There is undoubtedly an urgent need for novel treatments, strategies and anti-staphylococcal biofilm agents. The Sortase A (SrtA) transpeptidase is responsible for covalent anchoring to the cell wall of various surface proteins (FnbpA, FnbpB, Clf…