Search results for " spirometry"

showing 6 items of 16 documents

Recurrent respiratory infections caused by a double aortic arch: The diagnostic role of spirometry

2013

AbstractA young woman with a clinical history characterized by recurrent respiratory infections, occurring since early infancy, was referred to our hospital. When the patient was a young girl, she underwent sweat chloride test, serum analysis of immunoglobulins, and evaluation of blood lymphocyte subsets; all these diagnostic tests were normal, as well as chest X ray aside from pneumonia episodes. Skin prick tests were positive for several different allergens, and a diagnosis of allergic rhinitis was made. At the age of 11 years, she started to complain of gastroesophageal reflux disease (GERD) symptoms, and a gastroscopy detected a hiatal hernia with esophagitis. Despite pharmacologic trea…

Pulmonary and Respiratory MedicineSpirometrymedicine.medical_specialtyDouble aortic archmedicine.diagnostic_testbusiness.industryspirometryCase Reportdouble aortic arch; respiratory infections; spirometrydouble aortic archGastro-esophageal reflux symptomsmedicine.diseasePulmonary function testingSurgeryHiatal herniarespiratory infectionsChronic coughPneumoniamedicineGERDCentral airway obstructionmedicine.symptombusinessVascular ringsEsophagitisRespiratory Medicine Case Reports
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The Effect of Tiotropium in Symptomatic Asthma Despite Low- to Medium-Dose Inhaled Corticosteroids: A Randomized Controlled Trial.

2014

BackgroundTiotropium, a once-daily long-acting anticholinergic bronchodilator, has demonstrated efficacy in patients with asthma who were symptomatic despite treatment with medium- to high-dose inhaled corticosteroids (ICS).ObjectiveThe objective of this study was to evaluate the efficacy and safety of once-daily tiotropium Respimat (5 μg or 2.5 μg), compared with placebo Respimat, as add-on therapy to low- to medium-dose ICS for adults with symptomatic asthma.MethodsA phase III, double-blind, placebo-controlled trial was conducted (NCT01316380). Adults with symptomatic asthma receiving low- to medium-dose ICS (200-400 μg budesonide or equivalent dose) and a pre-bronchodilator forced expira…

SpirometryBudesonideAdultMaleRespimatmedicine.drug_classSymptomaticAnticholinergicMildPlacebo03 medical and health sciences0302 clinical medicineBronchodilatorsAdrenal Cortex HormonesBronchodilatorControlAdministration InhalationImmunology and AllergyMedicineHumans030212 general & internal medicineTiotropium BromideBudesonideAnticholinergic; Asthma; Bronchodilators; Control; GINA; ICS; Mild; Respimat; Symptomatic; Tiotropium; Administration Inhalation; Adrenal Cortex Hormones; Adult; Asthma; Bronchodilator Agents; Budesonide; Disease Progression; Drug Combinations; Female; Humans; Male; Placebo Effect; Spirometry; Tiotropium Bromide; Treatment Outcome; Immunology and AllergyAsthmamedicine.diagnostic_testbusiness.industryTiotropiumTiotropium bromidemedicine.diseasePlacebo EffectGINAAsthmarespiratory tract diseasesRespimatBronchodilator AgentsDrug CombinationsTreatment OutcomeInhalation030228 respiratory systemTolerabilityICSSpirometryAnesthesiaAdministrationDisease ProgressionFemalebusinessmedicine.drugThe journal of allergy and clinical immunology. In practice
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The airway response to deep inspirations decreases with COPD severity and is associated with airway distensibility assessed by computed tomography.

2008

In patients with mild chronic obstructive pulmonary disease (COPD), the effect of deep inspirations (DIs) to reverse methacholine-induced bronchoconstriction is largely attenuated. In this study, we tested the hypothesis that the effectiveness of DI is reduced with increasing disease severity and that this is associated with a reduction in the ability of DI to distend the airways. Fifteen subjects [Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage I–II: n = 7; GOLD stage III–IV: n = 8] underwent methacholine bronchoprovocation in the absence of DI, followed by DI. The effectiveness of DI was assessed by their ability to improve inspiratory vital capacity and forced expira…

SpirometryHigh-resolution computed tomographyPhysiologyRespiratory SystemVital CapacityHyperinflationSettore MED/10 - Malattie Dell'Apparato RespiratorioSeverity of Illness IndexBronchial Provocation TestsBronchoconstrictor AgentsAirway-parenchyma interdependencePulmonary Disease Chronic ObstructiveBronchoprovocationPhysiology (medical)Forced Expiratory VolumeSeverity of illnessAdministration InhalationmedicineHumansHigh-resolution computed tomographyMethacholine ChlorideAgedAged 80 and overCOPDMethacholinemedicine.diagnostic_testbusiness.industryAirway-parenchyma interdependence; Bronchoprovocation; High-resolution computed tomography; Hyperinflation; Methacholine; Administration Inhalation; Aged; Aged 80 and over; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Elasticity; Forced Expiratory Volume; Humans; Methacholine Chloride; Middle Aged; Pulmonary Disease Chronic Obstructive; Respiratory System; Severity of Illness Index; Spirometry; Vital Capacity; Inhalation; Tomography Spiral Computed; Physiology; Physiology (medical)Respiratory diseaseArticlesrespiratory systemMiddle Agedmedicine.diseaseElasticityrespiratory tract diseasesBronchial Provocation TestInhalationSpirometryAnesthesiaBronchoconstrictor AgentBronchoconstrictionMethacholinemedicine.symptomBronchial HyperreactivityAirwaybusinessTomography Spiral ComputedHumanmedicine.drugJournal of applied physiology (Bethesda, Md. : 1985)
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Development of a nomogram to estimate the quality of life in asthmatic children using the Childhood Asthma Control Test

2016

Background: Pediatric Asthma Quality of Life Questionnaire (PAQLQ) provides detailed information on QoL in asthmatic children, whereas Childhood Asthma Control Test (C-ACT) Questionnaire is the most validated instrument for asthma control. No study assessed the relationship between C-ACT and QoL in children by means of those instruments. The aim of this study was to determine whether a QoL estimation is possible using the C-ACT questionnaire in asthmatic children. Methods: Medical history, spirometry, C-ACT, and PAQLQ were assessed in 144 (60% male) outpatient asthmatic children from September 2011 to November 2014. A generalized linear model (GLM) for the prediction of PAQLQ was obtained t…

SpirometryMalePediatricsmedicine.medical_specialtyPediatric Asthma Quality of Life QuestionnaireImmunologyPediatricsSeverity of Illness IndexChildhood Asthma Control Testnomogram03 medical and health sciencesFEV1/FVC ratio0302 clinical medicineQuality of lifechildren030225 pediatricsSurveys and QuestionnairesSeverity of illnessMedicineImmunology and AllergyHumansMedical historyPreschoolChildAsthmaChildhood asthmaasthma; Childhood Asthma Control Test; children; control; nomogram; Pediatric Asthma Quality of Life Questionnaire; Asthma; Child; Child Preschool; Female; Humans; Italy; Male; Pediatrics; Prognosis; Reproducibility of Results; Severity of Illness Index; Spirometry; Surveys and Questionnaires; Nomograms; Quality of Life; Pediatrics Perinatology and Child Health; Immunology and Allergy; Immunologymedicine.diagnostic_testbusiness.industryReproducibility of ResultsNomogramPerinatology and Child Healthasthmamedicine.diseasePrognosisNomograms030228 respiratory systemItalySpirometryChild PreschoolPediatrics Perinatology and Child HealthQuality of LifeFemaleasthma; Childhood Asthma Control Test; children; control; nomogram; Pediatric Asthma Quality of Life Questionnaire; Pediatrics Perinatology and Child Health; Immunology and Allergy; Immunologybusinesscontrol
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A model-based approach for assessing bronchodilator responsiveness in children: The conventional cutoff revisited

2020

An increase in FEV1 >=12% has been proposed in international guidelines as a clue to airway reversibility for diagnosing asthma in both adults and children. However, the validity of this cut-off has been questioned in the pediatric population. The aim of this study was to provide evidence that different cut-off values in BDR may be associated with better performance in discriminating among outpatient children with naïve asthma (A) and without asthma (NA). We compared three approaches: i) the conventional cutoff (12%); ii) the cut-off estimated by Youden's criteria; and iii) the cut-off based on a model-driven approach. we found that the conventional cut-off of 12% showed poor sensitivity in…

SpirometryMalePediatricsmedicine.medical_specialtycut-offAdolescentmedicine.drug_classImmunologyspirometrySensitivity and Specificitysegmented modelchildrenReference ValuesBronchodilatorForced Expiratory VolumeImmunology and AllergyMedicineCutoffHumansChildAsthmaModels Statisticalmedicine.diagnostic_testbusiness.industryasthmachildren asthma spirometry bronchodilator response cut-offmedicine.diseaseBronchodilator AgentsChild PreschoolFemalebronchodilator responsedynamic nomogrambusiness
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Comorbidities and quality of life in obstructed adults in a primary care setting

2016

Introduction: Comorbidities are known to impair Quality of Life (QoL)in patients with chronic obstruction pulmonary disease. A poor QoL is associated with higher dyspnoea perception. How comorbidities influence QoL in these patients is limited and needs clarification. Aim: To study the role of dyspnoea perception in the relationship between comorbidities number and QoL in obstructed and not obstructed adults in a primary care setting. Methods: Seventeen general practitioners participated to the study: 566 adults, attending the Practitioner9s study for any reason, performed spirometry and fulfilled a respiratory questionnaire between January and June 2014. 259 adults (148 M, aged 40-88) acce…

Spirometrymedicine.medical_specialtyQuality of life. Spirometry Comorbiditiesmedicine.diagnostic_testbusiness.industrySignificant differencePrimary caremedicine.diseaseComorbidityMental healthhumanitiesFEV1/FVC ratioQuality of lifemedicineGlobal healthPhysical therapybusiness
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