Search results for " stem cell"
showing 10 items of 1957 documents
Poly-lactic acid and fibrinoin scaffolds as three-dimensional device to differentiate cardiac stem cells: in vitro and in vivo studies
2010
Italian Journal of Anatomy and Embryology, Vol 115, No 1/2 (Supplement) 2010
The role of biomaterials in the direction of cardiac stem cells properties, differentiation and extracellular matrix interactions in cardiac tissue e…
2011
Introduction: One of the main problems in the rapid translation of preclinical cell‐based therapy to restore damaged myocardium is to find the best delivery route and the best time of cell injection into the myocardium. Intramyocardial injection of stem cells is by far the mostused delivery technique in preclinical studies. Three‐dimensional scaffolds may be used to deliver a limited number of stem cells in their undifferentiated state, but many biomaterials may cause a foreign body reaction on their own. We have recently demonstrated that c‐Kit positive cardiac progenitor cells are able to organize themselves into a tissue‐like cell mass in collagen I three‐dimensional cultures within 72h …
STEM CELLS FOR TREATMENT OF CARDIOVASCULAR DISEASES: AN UMBRELLA REVIEW OF RANDOMIZED CONTROLLED TRIALS
2021
AIMS:\ud \ud Stem cells are a promising therapy for various medical conditions. The literature regarding their adoption for the clinical care of cardiovascular diseases (CVD) is still conflicting. Therefore, our aim is to assess the strength and credibility of the evidence on clinical outcomes and application of stem cells derived from systematic reviews and meta-analyses of intervention studies in CVD.\ud \ud METHODS and RESULTS:\ud \ud Umbrella review of systematic reviews with meta-analyses of randomized controlled trials (RCTs) using placebo/no intervention as control group. For meta-analyses of RCTs, outcomes with a random-effect p-value< 0.05, the GRADE (Grading of Recommendations Ass…
Erratum: Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression (Cell Stem Cell (201…
2016
Mouse mesoangioblast behaviour when subjected to cellular stress
2009
The surface modification of polymers to modulate endothelial cell growth
1996
The effect of nitrogen ion implantation or ion-assisted film deposition on the growth of human endothelial cells in vitro on a substrate has been studied. It was shown that the largest change occurs when TiO2 films were reactively sputtered onto the substrates, while the most passive surface was reactively sputtered SiO2. SEM pictures of the cells adhering to the various treated surfaces show that the cells were healthy. Future studies on the effect of alloy films and their oxides and nitrides are proposed.
Reactive oxygen species mediate angiotensin II-induced leukocyte-endothelial cell interactions in vivo
2001
Abstract Chronically elevated angiotensin II (Ang-II)-induced hypertension is partly mediated by superoxide production. In this study, we have investigated whether the leukocyte-endothelial cell interactions elicited by Ang-II involve reactive oxygen species (ROS) generation. Intravital microscopy within the rat mesenteric microvessels was used. Superfusion (60 min) with Ang-II (1 nM) induced significant increases in leukocyte rolling flux, adhesion, and emigration, which were inhibited by pretreatment with superoxide dismutase or catalase. Dihydrorhodamine-123 oxidation indicated that ROS are primarily produced by the vessel wall. Administration of dimethylthiourea, desferrioxamine, or N-a…
Comparative Biological Properties and Mineralization Potential of 3 Endodontic Materials for Vital Pulp Therapy: Theracal PT, Theracal LC, and Bioden…
2021
INTRODUCTION The aim of this study was to assess the biological properties and mineralization potential of the new Theracal PT (Bisco Inc, Schaumburg, IL) compared with its predecessor Theracal LC (Bisco Inc) and the hydraulic silicate-based cement Biodentine (Septodont, Saint-Maur-des-Fosses, France) on human dental pulp stem cells (hDPSCs) in vitro. METHODS Standardized sample discs were obtained for each material (n = 30) together with 1:1, 1:2, and 1:4 material eluates. Previously characterized hDPSCs were cultured with the different materials in standardized conditions, and the following assays were performed: a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, a woun…
Microcirculatory Dysfunction Induced by Cigarette Smoking
2000
This review deals with the deleterious effects of cigarette smoking on the microcirculation, both in terms of morphological (i.e., vessel wall injury, capillary loss) and functional aspects. The latter concerns predominantly changes in tissue perfusion and its regulatory mechanisms (i.e., reactive hyperemia, sequestration of blood cells in the microcirculation). The mechanisms of action of cigarette smoking on the microcirculation include compromised endothelial-dependent vasorelaxation, platelet aggregation, endothelial cell dysfunction, and the activation of circulating leukocytes. Through these mechanisms, cigarette smoking elicits the aggregation and adhesion of leukocytes and/or platel…
Zebrafish Fins as a Model System for Skeletal Human Studies
2007
Recent studies on the morphogenesis of the fins ofDanio rerio(zebrafish) during development and regeneration suggest that a number of inductive signals involved in the process are similar to some of those that affect bone and cartilage differentiation in mammals and humans. Akimenko et al. (2002) has shown that bone morphogenetic protein-2b (BMP2b) is involved in the induction of dermal bone differentiation during fin regeneration. Many other groups have also shown that molecules from the transforming growth factor-beta superfamily (TGFβ), including BMP2, are effective in promoting chondrogenesis and osteogenesisin vivoin higher vertebrates, including humans. In the present study, we review…