Search results for " storage"

Long-term enzyme-replacement therapy (ERT) with alglucosidase alfa: Evolution of two siblings with juvenile late-onset Pompe disease

2015

Recombinant FVIII Products (Turoctocog Alfa and Turoctocog Alfa Pegol) Stable Up to 40°C

2021

Mariasanta Napolitano,1 Arne Agerlin Olsen,2 Anne Mette Nøhr,2 Hermann Eichler3 1Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo Reference Regional Center for Thrombosis and Hemostasis, Hematology Unit, Palermo, Italy; 2Novo Nordisk A/S, Biopharm Manufacturing Development, Gentofte, Denmark; 3Saarland University and Saarland University Hospital, Institute of Clinical Haemostaseology and Transfusion Medicine, Homburg (Saar), GermanyCorrespondence: Anne Mette NøhrBiopharm Manufacturing Development, Novo Nordisk A/S, Nybrovej 80, Gentofte 2820, DenmarkTel +45 3075 1619Email amnq@novonordisk.…

Snapshot Spectral Imaging

2018

This chapter describes an application of the spline-based wavelet frames to the spectral imaging. It presents a method that enables to convert a regular digital camera into a snapshot spectral imager by equipping the camera with a dispersive diffuser and with a compressed sensing-based algorithm for digital processing. The method relies on the assumption that typical images can be sparsely represented in the frame domain. The solution is found from the constrained \(l_{1}\) minimization of a functional by Bregman iterations. Results of optical experiments are reported. The chapter is based on the paper (Golub et al., Appl. Opt. 55, 432–443, (2016), [11]).

Patient preferences in the treatment of hemophilia A: impact of storage conditions on product choice

2018

Bernd Tischer,1 Renato Marino,2 Mariasanta Napolitano3 1Kantar Health, Munich, Germany; 2Haemophilia and Thrombosis Centre, University Hospital of Bari, Apulia, Italy; 3University of Palermo, Reference Regional Center for Thrombosis and Hemostasis Hematology Unit, Palermo, Italy Objectives: To gain insights into the usage of factor VIII (FVIII) products by patients diagnosed with moderate/severe hemophilia A, and to assess the impact and perceived importance of product storage.Methods: In this study, 200 patients diagnosed with moderate or severe hemophilia A across seven countries participated. Data were collected via a 30-minute, face-to-face interview in six countries and via a web-based…

Instability of misoprostol tablets stored outside the blister: a potential serious concern for clinical outcome in medical abortion.

2014

IntroductionMisoprostol (Cytotec) is recognised to be effective for many gynaecological indications including termination of pregnancy, management of miscarriage and postpartum haemorrhage. Although not licensed for such indications, it has been used for these purposes by millions of women throughout the world. Misoprostol tablets are most often packaged as multiple tablets within an aluminium strip, each within an individual alveolus. When an alveolus is opened, tablets will be exposed to atmospheric conditions.ObjectiveTo compare the pharmaco technical characteristics (weight, friability), water content, misoprostol content and decomposition product content (type A misoprostol, type B mis…

Mucopolysaccharidoses and other lysosomal storage diseases.

2013

Mucopolysaccharidosis and other lysosomal storage diseases are rare, chronic, and progressive inherited diseases caused by a deficit of lysosomal enzymes. Patients are affected by a wide variety of symptoms. For some lysosomal storage diseases, effective treatments to arrest disease progression, or slow the pathologic process, and increase patient life expectancy are available or being developed. Timely diagnosis is crucial. Rheumatologists, orthopedics, and neurologists are commonly consulted due to unspecific musculoskeletal signs and symptoms. Pain, stiffness, contractures of joints in absence of clinical signs of inflammation, bone pain or abnormalities, osteopenia, osteonecrosis, secon…

Sensor to safeguard quality in the conservation of siciian extra virgin olive oil

2020

The production of olive oil in Sicily, in recent decades, has implemented the use of technologies that have as their main objective the sustainable safeguarding of food quality. Food quality both from the point of view of the transformation process, and from the point of view of product conservation, from olive oil is not a simple condiment but involves important nutritional attentions with health implications. The preservation of bottled olive oil is fundamental in order to improve the life cycle of the product after its transformation, in shelf life. The parameters observed during the observed conservation and storage period; temperature and relative humidity. The information collected is…

Impact of Ageing on Pea Protein Volatile Compounds and Correlation with Odor

2022

Vegetal proteins are of high interest for their many positive aspects, but their ‘beany’ off-flavor is still limiting the consumer’s acceptance. The aim of this work was to investigate the conservation of pea protein isolate (PPI) during time and especially the evolution of their organoleptic quality under two storage conditions. The evolution of the volatile compounds, the odor and the color of a PPI has been investigated during one year of storage. PPI was exposed to two treatments mimicking a lack of control of storage conditions: treatment A with light exposition at ambient temperature (A—Light 20 °C) and treatment B in the dark but with a higher temperature …

Optimization of BESS Capacity Under a Peak Load Shaving Strategy

2018

Battery energy storage systems (BESSs) are becoming increasingly competitive in the global energy landscape, thanks to the strong cost reduction that has taken place in recent years and it is expected to continue in the next future. Among the many benefits BESSs can provide, time shifting can be exploited by electricity consumers to save on the electricity bill, charging the storage during the off-peak hours and discharging when the cost of electricity is high. This paper describes a simple procedure to optimize the BESS capacity under a peak load shaving strategy, in presence of a time-of-use (TOU) electricity rate, able to guarantee, at the same time, the flattest daily power diagram and …

DEMAND Project: A Peak Load Shaving Strategy for End-User Consumers

2018

Battery energy storage systems (BESS) are becoming increasingly widespread in modern power systems, thanks to the important benefits they can provide to the electricity grid. Indeed, BESS can be used in time shifting applications, storing energy during off-peak periods and discharging during peak times (when the cost of electricity is high). When BESS are used for peak shaving purposes, they also contribute to relieve peak demand charges, thus ensuring a saving for the consumers. This paper describes a peak load shaving strategy defined within the DEMAND project. The strategy is able to guarantee the flattest daily power diagram and the maximum benefit for the electricity consumers, reducin…