Search results for " suppression"
showing 10 items of 121 documents
Automatic segmentation of the spine by means of a probabilistic atlas with a special focus on ribs suppression
2017
[EN] Purpose: The development of automatic and reliable algorithms for the detection and segmentation of the vertebrae are of great importance prior to any diagnostic task. However, an important problem found to accurately segment the vertebrae is the presence of the ribs in the thoracic region. To overcome this problem, a probabilistic atlas of the spine has been developed dealing with the proximity of other structures, with a special focus on ribs suppression. Methods: The data sets used consist of Computed Tomography images corresponding to 21 patients suffering from spinal metastases. Two methods have been combined to obtain the final result: firstly, an initial segmentation is performe…
Inducible Genetic Code Expansion in Eukaryotes
2020
Abstract Genetic code expansion (GCE) is a versatile tool to site‐specifically incorporate a noncanonical amino acid (ncAA) into a protein, for example, to perform fluorescent labeling inside living cells. To this end, an orthogonal aminoacyl‐tRNA‐synthetase/tRNA (RS/tRNA) pair is used to insert the ncAA in response to an amber stop codon in the protein of interest. One of the drawbacks of this system is that, in order to achieve maximum efficiency, high levels of the orthogonal tRNA are required, and this could interfere with host cell functionality. To minimize the adverse effects on the host, we have developed an inducible GCE system that enables us to switch on tRNA or RS expression whe…
Cytotoxicity of tumor antigen specific human T cells is unimpaired by arginine depletion.
2013
Tumor-growth is often associated with the expansion of myeloid derived suppressor cells that lead to local or systemic arginine depletion via the enzyme arginase. It is generally assumed that this arginine deficiency induces a global shut-down of T cell activation with ensuing tumor immune escape. While the impact of arginine depletion on polyclonal T cell proliferation and cytokine secretion is well documented, its influence on chemotaxis, cytotoxicity and antigen specific activation of human T cells has not been demonstrated so far. We show here that chemotaxis and early calcium signaling of human T cells are unimpaired in the absence of arginine. We then analyzed CD8(+) T cell activation…
Length of endodontic files measured in digital radiographs with and without noise-suppression filters: an ex-vivo study
2011
The aim of this study is to evaluate if theoretically possible edge shifts induced by noise-suppression filters potentially occur on objects found in digital radiographs. Most manufacturers carry out noise-suppression filtering of their images before they are displayed to the user. It is not usually possible for the user to disrupt the function of the filters. The use of these filters can lead to deletion of small image structures.K-files (ISO size 06, 08, 10 and 15) were placed in the root canals of 6 human teeth located in cadaver jaw segments. File tip positions were measured on original and filtered digital images by three observers. The file position was marked on each filtered image a…
Development and validation of the thought control ability questionnaire
2005
12 pages, 3 tables.-- Available online Sep 11, 2004.
Does risk of small mustelid predation affect the oestrous cycle in the bank vole,Clethrionomys glareolus?
1996
Female bank voles suppress their reproduction when the risk of small mustelid predation is high. The mechanism for this reproductive suppression is unknown. Because rodents are known to alter their oestrous cycle in response to changing environmental conditions, the eVect of predation risk on the oestrous cycle of bank vole females was studied. The oestrous cycles of 24 females divided into two treatments (predation risk and control) were observed for 20 days using female receptivity as an indication of oestrus. Voles exposed for 2-3 h a day for 20 days to the close presence of a least weasel, Mustela nivalis nivalis, had fewer oestrous cycles than control females exposed to a domestic rabb…
Disrupting immune regulation incurs transient costs in male reproductive function.
2014
9 pages; International audience; BACKGROUND: Immune protection against pathogenic organisms has been shown to incur costs. Previous studies investigating the cost of immunity have mostly focused on the metabolic requirements of immune maintenance and activation. In addition to these metabolic costs, the immune system can induce damage to the host if the immune response is mis-targeted or over-expressed. Given its non-specific nature, an over-expressed inflammatory response is often associated with substantial damage for the host. Here, we investigated the cost of an over-expressed inflammatory response in the reproductive function of male mice. METHODOLOGY/PRINCIPAL FINDINGS: We experimenta…
General balance functions of identified charged hadron pairs of (π,K,p) in Pb–Pb collisions at √sNN = 2.76 TeV
2022
First measurements of balance functions (BFs) of all combinations of identified charged hadron (π,K,p) pairs in Pb−Pb collisions at √sNN = 2.76 TeV recorded by the ALICE detector are presented. The BF measurements are carried out as two-dimensional differential correlators versus the relative rapidity (Δy) and azimuthal angle (Δφ) of hadron pairs, and studied as a function of collision centrality. The Δφ dependence of BFs is expected to be sensitive to the light quark diffusivity in the quark−gluon plasma. While the BF azimuthal widths of all pairs substantially decrease from peripheral to central collisions, the longitudinal widths exhibit mixed behaviors: BFs of ππ and cross-species pairs…
Interferon-α Abrogates Tolerance Induction by Human Tolerogenic Dendritic Cells
2011
Background Administration of interferon-α (IFN-α) represents an approved adjuvant therapy as reported for malignancies like melanoma and several viral infections. In malignant diseases, tolerance processes are critically involved in tumor progression. In this study, the effect of IFN-α on tolerance induction by human tolerogenic dendritic cells (DC) was analyzed. We focussed on tolerogenic IL-10-modulated DC (IL-10 DC) that are known to induce anergic regulatory T cells (iTregs). Methodology/Principal Findings IFN-α promoted an enhanced maturation of IL-10 DC as demonstrated by upregulation of the differentiation marker CD83 as well as costimulatory molecules. IFN-α treatment resulted in an…
Two maintenance mechanisms of verbal information in working memory
2009
Abstract The present study evaluated the interplay between two mechanisms of maintenance of verbal information in working memory, namely articulatory rehearsal as described in Baddeley’s model, and attentional refreshing as postulated in Barrouillet and Camos’s Time-Based Resource-Sharing (TBRS) model. In four experiments using complex span paradigm, we manipulated the degree of articulatory suppression and the attentional load of the processing component to affect orthogonally the two mechanisms of maintenance. In line with previous neurophysiological evidence reported in the literature, behavioral results suggest that articulatory rehearsal and attentional refreshing are two independent m…