Search results for " switching"
showing 10 items of 176 documents
Wall mannoproteins in cells from colonial phenotypic variants of Candida albicans.
1990
Candida albicans ATCC 26555 switched at high frequency (10(-1) to 10(-3)) between several phenotypes identified by colony morphology on a defined mineral amino-acid-containing agar medium supplemented with arginine and zinc (LAZ medium). When cells taken from colonies exhibiting distinct morphologies were plated directly onto LAZ agar, spontaneous conversion to all the variant phenotypes occurred at combined frequencies of 2.1 x 10(-1) to 9.5 x 10(-3). However, when cells taken from the different colonial phenotypes were plated directly onto an undefined medium (yeast extract/peptone/dextrose; YPD medium), or first incubated in liquid YPD medium and then cloned on YPD agar, all colonies obs…
Cultures in interaction : construction of ethnic identities in Amy Tan's "The bonesetter's daughter"
2007
Groupware architecture for requirements processes in new product development
1999
An organization's ability to create successful products depends on how extensively it collects, analyzes and utilizes requirements information in its product development. Recent advances in groupware technologies allow such information to be shared more effectively in distributed organizations; thus, these technologies hold considerable potential as means of shortening the cycle time and improving the quality of requirements processes. This paper addresses issues in the design and implementation of groupware-supported requirements processes by drawing on experiences from large-scale industrial development projects within Nokia. The primary contribution of the paper is the conceptual design …
Benefits and Drawbacks of A High Frequency Gan Zvzcps Converter
2017
This paper presents the benefits and drawbacks of replacing the traditional Si Mosfets transistors with enhancement mode GaN transistors in a Half-Bridge Zero Voltage and Zero Current Switching Power Switching (ZVZCPS) converter. This type of converters is usually used as Electronic Power Converters (EPC) for telecommunication satellites travelling-wave tube amplifiers (TWTAs). In this study, firstly the converter is theoretically analysed, obtaining its operation, losses and efficiency equations. From these equations, optimizations maps based on the main system parameters are obtained. These optimization maps are the key to quantify the potential benefits of GaN transistors in this type of…
Effects of high-fat diet and physical activity on pyruvate dehydrogenase kinase-4 in mouse skeletal muscle
2012
Abstract Background The expression of PDK4 is elevated by diabetes, fasting and other conditions associated with the switch from the utilization of glucose to fatty acids as an energy source. It is previously shown that peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), a master regulator of energy metabolism, coactivates in cell lines pyruvate dehydrogenase kinase-4 (PDK4) gene expression via the estrogen-related receptor α (ERRα). We investigated the effects of long-term high-fat diet and physical activity on the expression of PDK4, PGC-1α and ERRα and the amount and function of mitochondria in skeletal muscle. Methods Insulin resistance was induced by a high-fat (HF) d…
A Multiple Surrogate Assisted Decomposition Based Evolutionary Algorithm for Expensive Multi/Many-Objective Optimization
2019
Many-objective optimization problems (MaOPs) contain four or more conflicting objectives to be optimized. A number of efficient decomposition-based evolutionary algorithms have been developed in the recent years to solve them. However, computationally expensive MaOPs have been scarcely investigated. Typically, surrogate-assisted methods have been used in the literature to tackle computationally expensive problems, but such studies have largely focused on problems with 1–3 objectives. In this paper, we present an approach called hybrid surrogate-assisted many-objective evolutionary algorithm to solve computationally expensive MaOPs. The key features of the approach include: 1) the use of mul…
Effects of high-fat diet and physical activity on pyruvate dehydrogenase kinase-4 in mouse skeletal muscle
2012
Background. The expression of PDK4 is elevated by diabetes, fasting and other conditions associated with the switch from the utilization of glucose to fatty acids as an energy source. It is previously shown that peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), a master regulator of energy metabolism, coactivates in cell lines pyruvate dehydrogenase kinase-4 (PDK4) gene expression via the estrogen-related receptor α (ERRα). We investigated the effects of long-term high-fat diet and physical activity on the expression of PDK4, PGC-1α and ERRα and the amount and function of mitochondria in skeletal muscle. Methods. Insulin resistance was induced by a high-fat (HF) diet for…
Opioid-induced hyperalgesia after rapid titration with intravenous morphine: Switching and re-titration to intravenous methadone.
2012
Rapid titration with intravenous morphine (IV-MO) provides fast and efficient pain relief in cancer patients with severe-excruciating pain. However, some patients, after an initially favourable response, can develop an hyperexcitated state unrelieved or worsened by further dose increments.Eighty-one patients admitted on emergency basis titrated with IV-MO were assessed.12 patients were unsuccessfully titrated with IV-MO. Switching to intravenous methadone (IV-ME) and titrating the doses proved to be successfully.In escalating opioid doses rapidly a recognition of the development of hyperalgesia should be suspected. Increasing doses of opioids may stimulate rather than inhibiting the central…
Przyczyny transferów poselskich w Sejmie w latach 2001-2015
2018
Celem niniejszego artykułu jest określenie przyczyn zmiany przynależności klubowej w Sejmie w latach 2001-2015. Pod pojęciem „transferu” rozumiane są wszelkie zmiany przynależności klubowej mające miejsce w trakcie kadencji Sejmu, takie jak: rozłamy, odejścia, przejścia. Transfery takie mogą istotnie zmienić układ sil wewnątrz parlamentu ukształtowany w wyborach. Intencją autora jest wskazanie przyczyn tego zjawiska w Sejmie oraz jego kategoryzacja. Dokonana analiza pokazuje zasadnicze metodologiczne trudności z określeniem obiektywnych przyczyn transferów. Najczęściej wskazuje się różnice ideowo-programowe, jednakże analiza uwarunkowań, w których transfery się dokonują sugeruje, że często …
Transfery poselskie jako źródło nowych inicjatyw politycznych
2017
Partie polityczne – zgodnie z klasycznym ujęciem M. Duvergera – powstają według wewnętrznego i zewnętrznego trybu. Celem niniejszego artykułu jest analiza powstawania partii politycznych w Polsce zgodnie z pierwszym trybem (wewnętrznym), wykorzystując do tego koncept „transferu parlamentarnego”, tj. zmian przynależności klubowej posłów skutkujących powstaniem nowej partii politycznej.